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Fusion gene ID: 17565 |
FusionGeneSummary for INTS12_CXXC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INTS12_CXXC4 | Fusion gene ID: 17565 | Hgene | Tgene | Gene symbol | INTS12 | CXXC4 | Gene ID | 57117 | 80319 |
| Gene name | integrator complex subunit 12 | CXXC finger protein 4 | |
| Synonyms | INT12|PHF22|SBBI22 | IDAX | |
| Cytomap | 4q24 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrator complex subunit 12PHD finger protein 22hypothetical nuclear factor SBBI22 | CXXC-type zinc finger protein 4CXXC finger 4Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)inhibition of the Dvl and axin complex protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96CB8 | Q9H2H0 | |
| Ensembl transtripts involved in fusion gene | ENST00000394735, ENST00000340139, ENST00000451321, | ENST00000394767, ENST00000466963, ENST00000426831, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: INTS12 [Title/Abstract] AND CXXC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INTS12 | GO:0016180 | snRNA processing | 16239144 |
| Tgene | CXXC4 | GO:0030178 | negative regulation of Wnt signaling pathway | 11113207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CN-5364-01A | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000394735 | ENST00000394767 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000394735 | ENST00000466963 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000394735 | ENST00000426831 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| In-frame | ENST00000340139 | ENST00000394767 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000340139 | ENST00000466963 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000340139 | ENST00000426831 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| In-frame | ENST00000451321 | ENST00000394767 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000451321 | ENST00000466963 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
| 5CDS-5UTR | ENST00000451321 | ENST00000426831 | INTS12 | chr4 | 106613133 | - | CXXC4 | chr4 | 105393523 | - |
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FusionProtFeatures for INTS12_CXXC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INTS12 | CXXC4 |
| Component of the Integrator complex, a complex involvedin the small nuclear RNAs (snRNA) U1 and U2 transcription and intheir 3'-box-dependent processing. The Integrator complex isassociated with the C-terminal domain (CTD) of RNA polymerase IIlargest subunit (POLR2A) and is recruited to the U1 and U2 snRNAsgenes (PubMed:16239144). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:16239144,ECO:0000269|PubMed:23904267}. | Acts as a negative regulator of the Wnt signalingpathway via its interaction with DVL1. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INTS12_CXXC4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_INTS12_ENST00000340139_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_15aa >In-frame_INTS12_ENST00000451321_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_234aa MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNISIKQEPKISSSLPSGNNNGKVLTTE KVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPITVQSSKDLPMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_INTS12_ENST00000340139_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_45nt >In-frame_INTS12_ENST00000451321_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_702nt ATGGCTGCTACTGTGAACTTGGAACTTGATCCCATTTTTTTGAAAGCACTAGGTTTCTTGCATTCAAAGAGTAAAGATTCTGCTGAAAAG CTAAAAGCACTGCTTGATGAATCTTTGGCTCGGGGCATTGATTCCAGTTACCGTCCATCTCAAAAGGATGTGGAGCCACCCAAAATTTCA AGCACAAAAAACATTTCCATTAAGCAAGAGCCCAAAATATCATCCAGTCTTCCTTCTGGTAATAATAATGGCAAGGTCCTCACAACTGAA AAGGTAAAGAAGGAAGCTGAAAAGAGACCTGCTGATAAAATGAAATCAGACATCACTGAAGGAGTTGATATTCCAAAGAAACCTAGATTG GAGAAACCAGAAACACAGTCATCTCCCATTACTGTCCAAAGTAGCAAGGATTTACCTATGGCTGACCTTTCCAGTTTTGAGGAGACCAGT GCTGATGATTTTGCCATGGAGATGGGATTGGCCTGCGTTGTTTGTAGGCAAATGATGGTGGCATCTGGCAATCAATTAGTAGAATGTCAG GAGTGCCATAATCTCTACCACCGAGATTGTCATAAACCCCAGGTGACAGACAAGGAAGCGAATGACCCTCGCCTGGTGTGGTATTGTGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_INTS12_ENST00000340139_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_4927nt AGGGACCACCGGGAACAGACGGATCGGCAGGGCGGGGCGGAACGGTGAGGCCATCTACTGAAACACAGAAGCAATTTTAAAAGAAAATGG AGGAAGTATAACTGATCTTTGCAGAAAGTGGGGAAGTGAGTTGACCAGAGAAGGATGAGAGAATTGCCAAGTTGTACTGAACGCCAAGCT GAGAATGGTGATTCTGAAGATAGAATGCGTTTGCAATGGCTGCTACTGTGAACTTGGAACTTGATCCCATTTTTTTGAAAGCACTAGGTT TCTTGCATTCAAAGAGTAAAGATTCTGCTGAAAAGCTAAAAGCACTGCTTGATGAATCTTTGGCTCGGGGCATTGATTCCAGTTACCGTC CATCTCAAAAGGATGTGGAGCCACCCAAAATTTCAAGCACAAAAAACATTTCCATTAAGCAAGAGCCCAAAATATCATCCAGTCTTCCTT CTGGTAATAATAATGGCAAGGTCCTCACAACTGAAAAGGTAAAGAAGGAAGCTGAAAAGAGACCTGCTGATAAAATGAAATCAGACATCA CTGAAGGAGTTGATATTCCAAAGAAACCTAGATTGGAGAAACCAGAAACACAGTCATCTCCCATTACTGTCCAAAGTAGCAAGGATTTAC CTATGGCTGACCTTTCCAGTTTTGAGGAGACCAGTGCTGATGATTTTGCCATGGAGATGGGATTGGCCTGCGTTGTTTGTAGGCAAATGA TGGTGGCATCTGGCAATCAATTAGTAGAATGTCAGGAGTGCCATAATCTCTACCACCGAGATTGTCATAAACCCCAGGTGACAGACAAGG AAGCGAATGACCCTCGCCTGGTGTGGTATTGTGCCCGATGTACCAGACAAATGAAAAGAATGAGAACACCTGTTCCCAGCGCTGAAGCAT TCCGATGGTTCTTTTAAAGCAGTAGTATATCTTATTTTCAAGGCATTTGGAAATGAAGGGCAAACTAATGTCTTGTTTTAAGAAACTGCT TAGTCCACCACTGAAGAAAATATCCAGAAATTATTTTCATTTTATGTATAGGGCTTTCTTCAAAAAAAAAAAAAAAGAGGAAAAGAAAAG AAAAAGACATAAAAATAATGTGAGAGCTTGGAGAATTGGCCAGTCTATTTACTTTCAATACGCTGATTCTTTCTTTGATGTAATTTAGCT ATAGTAGTGAAGTTGTTGTCTATTTTGAAAGTGGCTGTAAAAAATAAGTTTGGGTAAACCCCTGCTGTAAAATCATGTATCTTTGCAAAG TACATATCTATACTTCATTTTCAAATATATGTGTTTCAGTACTGTAAACTGTACAGATAGCAGCTTGTATTTTGTGTGTTTAGACACAAG GAGACAATCATGTCTGAGCATCTATGGAGATTAACAGTTTGTACACAACAGTATGGTTCTGCAAGTTAAATCTGGAGCAATAAATTTTAG CTTTAACTATTTTTTGCCAGTGGTTTAGAAGCAGCAACAGCACTGGCACCATTTTGCCATGCATCTTTCCATAGAGACTTGATGCCAAGT TTTACAAGACTAAAAGATTATGATGCATCCACCAATTACCTTCAGTTTTATTGTTATAAGAGGGGAAGATGTTATGAAAGTTTCAATTAA TCTTTTGAGCACTATATTAGAGTAGTGGTTATGCACTTGCATTGCTTACAAACGAGCTGTACAGAAGGGTATACCTCCCAAATACTTAGT GTAGTTGACTTGTCTTGGGTTGCACTGTAAGGCAGAGTACTCAGAGTAGTTGGAAAATGCAGAATCAGTTGTATAATTTTTTTTTATAAA AACGGTGTTTTTTAGGCTAAAGAATAAAGTATCATATCTTAGGAGGGGAAAATTTATAACTGACATTTTTTCCCCAGCCCAATATGGGCT GTATACGTTTTATTGTTTCTTAATTTTTTTCTTATTTTTTCTGTAGGAAAAAATCTTAATAAAAACTACCCCAATGTTTTAACTTCATGT ATGATATTAAATGGGTAGTTTTAACACTTGAATATGTTGAGGGCTTCTGCCTTGAGGCAGGGCTTGATATATTTTTAATTTACAAAGAAT TAAACATATTCATAAAAGTGAGGCATTTTATCTCTTTTTATTTTCTTTTCTCATAGCCACCCAGTTGGACTAGTGGTCTTCCCCTGGTCC TTCAGTAAAATGCTCCATTGCTGCCATTTCCATTGTTGTTACTTGATGCTTTCATTCCTGAGAAGGCAGGGCTACAGTCTCTGGAATTTC ATAAATGCATGACATACCCCTCCCCCCACAACCTACACACAAAGGATCTAATGCTTCATAGAACCTGTGCTACCTTTTCATGTTGGAGTT GGTTTTCTTATCACAGTCAGGGTTCTTAAGGCCGTCCCATCAGGACAAATATTTACCTTCCATTTTATTTCTGTTTGTCCCAATTATAAA GACTATTTTCAGTTTCAGGAGTAGAACAGGGTTTAGCAAAAATATGTAGAGTATCAAAGTTACCTACTGCAACTTTTTGTTCTTTGTCCA CTAGCCAGGTGATTTAACCCACTAAATCCATTAGCTTGCTGAAAAATGTTAGCAAAGTAAATCACGAGAAGAAAGATAATTTGAGAAGAG AAATGGTATGGTACAATGAAAGAAGCTGTAAAGATTAGGAAAGACTAGTAAGTGAATATTTTTAAAAATTTAGTTGTAGATTTCAATGGG ATACGATAGGACAGAAAAGATTTTTTAAAAAGCAGAAAGAGTGTTTCATGGTGAAAGTACTGGGGGAGGGTGGACAAAGCATGCACACAT GCCAATTTGAAAATCAAGTGTGACTTACCTCACGTAGAGTATGAATACATGGTCCACAGTTATGGTCAACAAGCGTTTTCAAGAAAAACT CATGATGTGTTACACCCATCCATATTTAGAGATGAGAATTAAATGATTACAAGCTAAAATGTGCTGTATACTGTATTAATTTTGAGATAG CTTTCTACTTGATGTATATTTCTTTGAGGGTTTCTATCTAGTTAGAATTTCAGCTTCTGCTGTGGGACCAATGAGAGCTGTATGAGTTTT TTTTTTTTTTTCCTTTTCCATTATTTTATTTTTTGTTTTTTGTTTACCAATTTGCTAATTAATTACAAGTAAGTGAAAACTTACTTTCAC ACTTGAATGATAAGCTTGCCTTGCTCTTTGGAAAATGATGATTGTTATTACAGAAGTGAAACAAACTTCTATTCAGGCTACAGTAGGCAT ACAATAACCTAAAGATCTCATAGAAGTATACTGAGAGTCTAAAATACATTCTAGTAGTGCATGTCTTGGTGTGCTTTTGTTTGTTTGCTT TCTAAAAGAACTAATGAATCTGTATATTGTAAACTGTGGTGTTTTACATGTCAATTCATTTTTTTAATGAAAGAAAATTTGTTGATTACT GAAATGAGAAAGTGTAGCTTTTCATTAATTCTCTTATGTTTTTTATTCTTGATATTGTTCTTTTATACCACCCACTTTTTAATGTTTTTG GTTAAACTCCATTTATATAATGTAGGATGCATATAAAGTTCTCATTGGTGATGTTGAAGAAAGAGATGACTCTTCTGGCCTTTCTCTAGT TTTCTTCCTCATATGTCCCTGTACTGAGAACTTCTAAAGCTTATCATTATAAACCTAAGGCAGTGATTTGAAAGTTTACATTTTTCATGA TTTTCAAATACCAATGAAATGTAACTTTTAAATATTCCTCACTGTGTGTTTTATATTCACTGTCAAGAAAATTCAGAATGTAGATTGTGT GGACAGCTATACACAACTTAATAATTATATATCAGATAAACTGAATAAAAAACTTTGTAAGAGTGGTCTACGCACACAGGATCTTGTCCT CCCTAGGCGTGGATAGAGAGATGCCATAATCTGCCAGCATTTGGGGAGATCATGGTAAATACTTGAGGCGTTGATACATAGTGCAGTGAG CCAATTTCCTTTTCAGTTGTCACTCAGCACCATAACATCACGAAGAACATCATTAATGCAAACCTCTCACTAAGCCTTCAGACCAAAGTG GCTTTCTGATGGACTCTGCCTGTCTGTCTACAAGTGGAGTCAGATTCAAAGTAGAAATGTATCCATCCTTGGGAAAGAAAATAGGAAGTC TTCCCCCACTGTAGGAGTATATAAAAATGTCTCCTGGTTGCTTAATTCCCAACACTCAATTTCCTTCTTCTAAACACATTTATAAGGAGC AAGAGATGGTGCACTTATTATGAATTAATATTAAGCAATCACTAAAAGAAAGGAATATTCTCTTCCTTTCAATCAGAAACCCTGATATGT AAGTTGTGCAATTAATGCTAAAGCATATAAAGTCTTTAAGCTGATAAGTATCTGTAATCAAATAATGAAAAAAGGAAAGCAGTTAAATGA ACACACTATTCAGGGTCAAATATGTTCAGCAAAAAGCCGTAGCGGGTCTTTGATCATGGTTAGATTCACAGTGATATCAAACAGTTGGTT CTCATGTAACAGCTAAATGTTTCAGTTTTTTTTTTTTTATTAAATTTGGCATTTCACACTGAGATCTGTATTCCTAGTGAATAAAAGACA GCTACTATATTAGGAGGGATTCCATTTTCACAATTGCAAAACAGATATTTCAGGAACATGGGCCACAAAATGTACTCCTTTCACAGTGTT CTCCTCTTCTGAACTGTGCAGTTATCTATTAAATTTTCTAATAGATATTTGTGTAAGGTGTATGTATGCTTGTGCAATTATTTAAAAAAC GGTTTTGGAAAACAGTGTATTTATTAAAGAAAATTACTTATGGGGCATGTACAAAACTGTAAAAAAAAAAAAAAAGTAAAAAAAATCACA >In-frame_INTS12_ENST00000451321_chr4_106613133_-_CXXC4_ENST00000394767_chr4_105393523_-_5192nt CGCATCCTCAGCCCTGCAGACCCCCGAAGAAAAGACCAGTTCTTAGGGGGTCGCGGAGGCTGAGAAGCCGGCGGCCCGAGCGCCCTCTTT ACCTGGTCGCAGAGGCGCGGCCAGGCAGGGAGGGTGCGTGAGCGTGTCGGCGACCTGGGCCGCCTGCGCCTTCCCGCCCAGTCCGAGCTG GAATTCCAAGGCTGCCTCTGGGAGCTGCTGCCCGCAGACCACTCGCCTCCACAGACGCCAGGAGAAAAACGACAGCCACCTTATGTGGAA AATACTCGCGCCGGCCGTCATTCATAATCCGGCGGACCGGAAAAAGGGAAGTAACGTCACTTCCTACTGTCGCACTGCCAAACGTTTCCC CCGCCCCTACTGTGGGAACCTTTGTTTTCCTGCTTTCGGAGCCGGCCAGTGCGGGAACCGTTTCCGAAGGGACCACCGGGAACAGACGGA TCGGCAGGGCGGGGCGGAACGGCGTTTGCAATGGCTGCTACTGTGAACTTGGAACTTGATCCCATTTTTTTGAAAGCACTAGGTTTCTTG CATTCAAAGAGTAAAGATTCTGCTGAAAAGCTAAAAGCACTGCTTGATGAATCTTTGGCTCGGGGCATTGATTCCAGTTACCGTCCATCT CAAAAGGATGTGGAGCCACCCAAAATTTCAAGCACAAAAAACATTTCCATTAAGCAAGAGCCCAAAATATCATCCAGTCTTCCTTCTGGT AATAATAATGGCAAGGTCCTCACAACTGAAAAGGTAAAGAAGGAAGCTGAAAAGAGACCTGCTGATAAAATGAAATCAGACATCACTGAA GGAGTTGATATTCCAAAGAAACCTAGATTGGAGAAACCAGAAACACAGTCATCTCCCATTACTGTCCAAAGTAGCAAGGATTTACCTATG GCTGACCTTTCCAGTTTTGAGGAGACCAGTGCTGATGATTTTGCCATGGAGATGGGATTGGCCTGCGTTGTTTGTAGGCAAATGATGGTG GCATCTGGCAATCAATTAGTAGAATGTCAGGAGTGCCATAATCTCTACCACCGAGATTGTCATAAACCCCAGGTGACAGACAAGGAAGCG AATGACCCTCGCCTGGTGTGGTATTGTGCCCGATGTACCAGACAAATGAAAAGAATGAGAACACCTGTTCCCAGCGCTGAAGCATTCCGA TGGTTCTTTTAAAGCAGTAGTATATCTTATTTTCAAGGCATTTGGAAATGAAGGGCAAACTAATGTCTTGTTTTAAGAAACTGCTTAGTC CACCACTGAAGAAAATATCCAGAAATTATTTTCATTTTATGTATAGGGCTTTCTTCAAAAAAAAAAAAAAAGAGGAAAAGAAAAGAAAAA GACATAAAAATAATGTGAGAGCTTGGAGAATTGGCCAGTCTATTTACTTTCAATACGCTGATTCTTTCTTTGATGTAATTTAGCTATAGT AGTGAAGTTGTTGTCTATTTTGAAAGTGGCTGTAAAAAATAAGTTTGGGTAAACCCCTGCTGTAAAATCATGTATCTTTGCAAAGTACAT ATCTATACTTCATTTTCAAATATATGTGTTTCAGTACTGTAAACTGTACAGATAGCAGCTTGTATTTTGTGTGTTTAGACACAAGGAGAC AATCATGTCTGAGCATCTATGGAGATTAACAGTTTGTACACAACAGTATGGTTCTGCAAGTTAAATCTGGAGCAATAAATTTTAGCTTTA ACTATTTTTTGCCAGTGGTTTAGAAGCAGCAACAGCACTGGCACCATTTTGCCATGCATCTTTCCATAGAGACTTGATGCCAAGTTTTAC AAGACTAAAAGATTATGATGCATCCACCAATTACCTTCAGTTTTATTGTTATAAGAGGGGAAGATGTTATGAAAGTTTCAATTAATCTTT TGAGCACTATATTAGAGTAGTGGTTATGCACTTGCATTGCTTACAAACGAGCTGTACAGAAGGGTATACCTCCCAAATACTTAGTGTAGT TGACTTGTCTTGGGTTGCACTGTAAGGCAGAGTACTCAGAGTAGTTGGAAAATGCAGAATCAGTTGTATAATTTTTTTTTATAAAAACGG TGTTTTTTAGGCTAAAGAATAAAGTATCATATCTTAGGAGGGGAAAATTTATAACTGACATTTTTTCCCCAGCCCAATATGGGCTGTATA CGTTTTATTGTTTCTTAATTTTTTTCTTATTTTTTCTGTAGGAAAAAATCTTAATAAAAACTACCCCAATGTTTTAACTTCATGTATGAT ATTAAATGGGTAGTTTTAACACTTGAATATGTTGAGGGCTTCTGCCTTGAGGCAGGGCTTGATATATTTTTAATTTACAAAGAATTAAAC ATATTCATAAAAGTGAGGCATTTTATCTCTTTTTATTTTCTTTTCTCATAGCCACCCAGTTGGACTAGTGGTCTTCCCCTGGTCCTTCAG TAAAATGCTCCATTGCTGCCATTTCCATTGTTGTTACTTGATGCTTTCATTCCTGAGAAGGCAGGGCTACAGTCTCTGGAATTTCATAAA TGCATGACATACCCCTCCCCCCACAACCTACACACAAAGGATCTAATGCTTCATAGAACCTGTGCTACCTTTTCATGTTGGAGTTGGTTT TCTTATCACAGTCAGGGTTCTTAAGGCCGTCCCATCAGGACAAATATTTACCTTCCATTTTATTTCTGTTTGTCCCAATTATAAAGACTA TTTTCAGTTTCAGGAGTAGAACAGGGTTTAGCAAAAATATGTAGAGTATCAAAGTTACCTACTGCAACTTTTTGTTCTTTGTCCACTAGC CAGGTGATTTAACCCACTAAATCCATTAGCTTGCTGAAAAATGTTAGCAAAGTAAATCACGAGAAGAAAGATAATTTGAGAAGAGAAATG GTATGGTACAATGAAAGAAGCTGTAAAGATTAGGAAAGACTAGTAAGTGAATATTTTTAAAAATTTAGTTGTAGATTTCAATGGGATACG ATAGGACAGAAAAGATTTTTTAAAAAGCAGAAAGAGTGTTTCATGGTGAAAGTACTGGGGGAGGGTGGACAAAGCATGCACACATGCCAA TTTGAAAATCAAGTGTGACTTACCTCACGTAGAGTATGAATACATGGTCCACAGTTATGGTCAACAAGCGTTTTCAAGAAAAACTCATGA TGTGTTACACCCATCCATATTTAGAGATGAGAATTAAATGATTACAAGCTAAAATGTGCTGTATACTGTATTAATTTTGAGATAGCTTTC TACTTGATGTATATTTCTTTGAGGGTTTCTATCTAGTTAGAATTTCAGCTTCTGCTGTGGGACCAATGAGAGCTGTATGAGTTTTTTTTT TTTTTTCCTTTTCCATTATTTTATTTTTTGTTTTTTGTTTACCAATTTGCTAATTAATTACAAGTAAGTGAAAACTTACTTTCACACTTG AATGATAAGCTTGCCTTGCTCTTTGGAAAATGATGATTGTTATTACAGAAGTGAAACAAACTTCTATTCAGGCTACAGTAGGCATACAAT AACCTAAAGATCTCATAGAAGTATACTGAGAGTCTAAAATACATTCTAGTAGTGCATGTCTTGGTGTGCTTTTGTTTGTTTGCTTTCTAA AAGAACTAATGAATCTGTATATTGTAAACTGTGGTGTTTTACATGTCAATTCATTTTTTTAATGAAAGAAAATTTGTTGATTACTGAAAT GAGAAAGTGTAGCTTTTCATTAATTCTCTTATGTTTTTTATTCTTGATATTGTTCTTTTATACCACCCACTTTTTAATGTTTTTGGTTAA ACTCCATTTATATAATGTAGGATGCATATAAAGTTCTCATTGGTGATGTTGAAGAAAGAGATGACTCTTCTGGCCTTTCTCTAGTTTTCT TCCTCATATGTCCCTGTACTGAGAACTTCTAAAGCTTATCATTATAAACCTAAGGCAGTGATTTGAAAGTTTACATTTTTCATGATTTTC AAATACCAATGAAATGTAACTTTTAAATATTCCTCACTGTGTGTTTTATATTCACTGTCAAGAAAATTCAGAATGTAGATTGTGTGGACA GCTATACACAACTTAATAATTATATATCAGATAAACTGAATAAAAAACTTTGTAAGAGTGGTCTACGCACACAGGATCTTGTCCTCCCTA GGCGTGGATAGAGAGATGCCATAATCTGCCAGCATTTGGGGAGATCATGGTAAATACTTGAGGCGTTGATACATAGTGCAGTGAGCCAAT TTCCTTTTCAGTTGTCACTCAGCACCATAACATCACGAAGAACATCATTAATGCAAACCTCTCACTAAGCCTTCAGACCAAAGTGGCTTT CTGATGGACTCTGCCTGTCTGTCTACAAGTGGAGTCAGATTCAAAGTAGAAATGTATCCATCCTTGGGAAAGAAAATAGGAAGTCTTCCC CCACTGTAGGAGTATATAAAAATGTCTCCTGGTTGCTTAATTCCCAACACTCAATTTCCTTCTTCTAAACACATTTATAAGGAGCAAGAG ATGGTGCACTTATTATGAATTAATATTAAGCAATCACTAAAAGAAAGGAATATTCTCTTCCTTTCAATCAGAAACCCTGATATGTAAGTT GTGCAATTAATGCTAAAGCATATAAAGTCTTTAAGCTGATAAGTATCTGTAATCAAATAATGAAAAAAGGAAAGCAGTTAAATGAACACA CTATTCAGGGTCAAATATGTTCAGCAAAAAGCCGTAGCGGGTCTTTGATCATGGTTAGATTCACAGTGATATCAAACAGTTGGTTCTCAT GTAACAGCTAAATGTTTCAGTTTTTTTTTTTTTATTAAATTTGGCATTTCACACTGAGATCTGTATTCCTAGTGAATAAAAGACAGCTAC TATATTAGGAGGGATTCCATTTTCACAATTGCAAAACAGATATTTCAGGAACATGGGCCACAAAATGTACTCCTTTCACAGTGTTCTCCT CTTCTGAACTGTGCAGTTATCTATTAAATTTTCTAATAGATATTTGTGTAAGGTGTATGTATGCTTGTGCAATTATTTAAAAAACGGTTT TGGAAAACAGTGTATTTATTAAAGAAAATTACTTATGGGGCATGTACAAAACTGTAAAAAAAAAAAAAAAGTAAAAAAAATCACATTCAA |
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FusionGenePPI for INTS12_CXXC4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| INTS12 | INTS1, INTS3, INTS5, INTS6, INTS10, APP, POLR2C, BSG, TAS2R7, KIR2DS2, SLAMF1, ST8SIA1, TGOLN2, ALDH3A2, PPP2CA, PPP2CB, PPP2R1A, VWA9, NELFA, FOXJ2, USP37, APLNR, IL13RA2, EDNRB, ILVBL, ARL13A, MAS1, F2RL1, FZD10, ST6GAL1, DKKL1, KDELR3, GTF2IRD1 | CXXC4 | FBXO25, APP, RAD51, TIA1, GPN3, PUS7, ZNFX1, BRD9, FOXL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INTS12_CXXC4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INTS12_CXXC4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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