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Fusion gene ID: 17546 |
FusionGeneSummary for INS-IGF2_PLCB2 |
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Fusion gene information | Fusion gene name: INS-IGF2_PLCB2 | Fusion gene ID: 17546 | Hgene | Tgene | Gene symbol | INS-IGF2 | PLCB2 | Gene ID | 723961 | 5330 |
Gene name | INS-IGF2 readthrough | phospholipase C beta 2 | |
Synonyms | INSIGF | PLC-beta-2 | |
Cytomap | 11p15.5 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | insulin, isoform 2INS-IGF2 readthrough transcript proteininsulin- insulin-like growth factor 2 read-through product | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2phosphoinositide phospholipase C-beta-2 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | F8WCM5 | Q00722 | |
Ensembl transtripts involved in fusion gene | ENST00000481781, ENST00000397270, | ENST00000260402, ENST00000557821, ENST00000456256, ENST00000543785, | |
Fusion gene scores | * DoF score | 22 X 31 X 1=682 | 3 X 3 X 1=9 |
# samples | 33 | 5 | |
** MAII score | log2(33/682*10)=-1.04730571477836 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: INS-IGF2 [Title/Abstract] AND PLCB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | N69137 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + | ||
ChiTaRS3.1 | N69126 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000481781 | ENST00000260402 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-intron | ENST00000481781 | ENST00000557821 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-intron | ENST00000481781 | ENST00000456256 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-3UTR | ENST00000481781 | ENST00000543785 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-intron | ENST00000397270 | ENST00000260402 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-intron | ENST00000397270 | ENST00000557821 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-intron | ENST00000397270 | ENST00000456256 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
intron-3UTR | ENST00000397270 | ENST00000543785 | INS-IGF2 | chr11 | 2150546 | + | PLCB2 | chr15 | 40593197 | + |
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FusionProtFeatures for INS-IGF2_PLCB2 |
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Hgene | Tgene |
INS-IGF2 | PLCB2 |
The production of the second messenger moleculesdiacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ismediated by activated phosphatidylinositol-specific phospholipaseC enzymes. {ECO:0000269|PubMed:1644792}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INS-IGF2_PLCB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for INS-IGF2_PLCB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INS-IGF2_PLCB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INS-IGF2_PLCB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |