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Fusion gene ID: 17525 |
FusionGeneSummary for INPP5F_GRK5 |
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Fusion gene information | Fusion gene name: INPP5F_GRK5 | Fusion gene ID: 17525 | Hgene | Tgene | Gene symbol | INPP5F | GRK5 | Gene ID | 22876 | 2869 |
Gene name | inositol polyphosphate-5-phosphatase F | G protein-coupled receptor kinase 5 | |
Synonyms | MSTP007|MSTPO47|SAC2|hSAC2 | GPRK5 | |
Cytomap | 10q26.11 | 10q26.11 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositide phosphatase SAC2Sac domain-containing inositol phosphatase 2sac domain-containing phosphoinositide 4-phosphatase 2sac domain-containing phosphoinositide 5-phosphatase 2 | G protein-coupled receptor kinase 5FP2025g protein-coupled receptor kinase GRK5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y2H2 | P34947 | |
Ensembl transtripts involved in fusion gene | ENST00000369083, ENST00000361976, ENST00000369081, ENST00000369080, ENST00000490818, | ENST00000392870, ENST00000369108, ENST00000473264, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 5 X 2=40 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: INPP5F [Title/Abstract] AND GRK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | INPP5F | GO:0001921 | positive regulation of receptor recycling | 25869669 |
Hgene | INPP5F | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein | 25476455 |
Hgene | INPP5F | GO:0046856 | phosphatidylinositol dephosphorylation | 11274189|25869669 |
Tgene | GRK5 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
Tgene | GRK5 | GO:0043066 | negative regulation of apoptotic process | 20124405 |
Tgene | GRK5 | GO:0046777 | protein autophosphorylation | 14976207 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A1ZD-06A | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000369083 | ENST00000392870 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
5CDS-5UTR | ENST00000369083 | ENST00000369108 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
5CDS-intron | ENST00000369083 | ENST00000473264 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
In-frame | ENST00000361976 | ENST00000392870 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
5CDS-5UTR | ENST00000361976 | ENST00000369108 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
5CDS-intron | ENST00000361976 | ENST00000473264 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-3CDS | ENST00000369081 | ENST00000392870 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-5UTR | ENST00000369081 | ENST00000369108 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-intron | ENST00000369081 | ENST00000473264 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-3CDS | ENST00000369080 | ENST00000392870 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-5UTR | ENST00000369080 | ENST00000369108 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-intron | ENST00000369080 | ENST00000473264 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-3CDS | ENST00000490818 | ENST00000392870 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-5UTR | ENST00000490818 | ENST00000369108 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
intron-intron | ENST00000490818 | ENST00000473264 | INPP5F | chr10 | 121485871 | + | GRK5 | chr10 | 121140327 | + |
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FusionProtFeatures for INPP5F_GRK5 |
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Hgene | Tgene |
INPP5F | GRK5 |
Serine/threonine kinase that phosphorylatespreferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiatesbeta-arrestin-mediated receptor desensitization, internalization,and signaling events leading to their down-regulation.Phosphorylates a variety of GPCRs, including adrenergic receptors,muscarinic acetylcholine receptors (more specifically Gi-coupledM2/M4 subtypes), dopamine receptors and opioid receptors. Inaddition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.Phosphorylation of ARRB1 by GRK5 inhibits G-protein independentMAPK1/MAPK3 signaling downstream of 5HT4-receptors.Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucialtumor suppressor, inhibits TP53/p53-mediated apoptosis.Phosphorylation of ST13 regulates internalization of the chemokinereceptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).{ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552,ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405,ECO:0000269|PubMed:21728385}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 186_448 | 49 | 591 | Domain | Protein kinase |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 449_514 | 49 | 591 | Domain | Note=AGC-kinase C-terminal |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 53_171 | 49 | 591 | Domain | RGS |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 388_395 | 49 | 591 | Motif | Nuclear localization signal |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 192_200 | 49 | 591 | Nucleotide binding | ATP |
Tgene | >GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 546_565 | 49 | 591 | Region | Note=Sufficient for membrane localization |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000361976 | + | 1 | 20 | 167_518 | 32 | 1133 | Domain | SAC |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000361976 | + | 1 | 20 | 593_760 | 32 | 1133 | Domain | hSac2 |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000369080 | + | 1 | 6 | 167_518 | -256 | 523 | Domain | SAC |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000369080 | + | 1 | 6 | 593_760 | -256 | 523 | Domain | hSac2 |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000369083 | + | 1 | 10 | 167_518 | 32 | 376 | Domain | SAC |
Hgene | >INPP5F | chr10:121485871 | chr10:121140327 | ENST00000369083 | + | 1 | 10 | 593_760 | 32 | 376 | Domain | hSac2 |
Tgene | GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 1_185 | 49 | 591 | Region | Note=N-terminal |
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FusionGeneSequence for INPP5F_GRK5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_INPP5F_ENST00000369083_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_574aa MELFQAKDHYILQQGERALWCSRRDGGLQLRPDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMT KYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGF GEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE MIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP DPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKR >In-frame_INPP5F_ENST00000361976_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_574aa MELFQAKDHYILQQGERALWCSRRDGGLQLRPDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMT KYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGF GEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE MIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP DPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_INPP5F_ENST00000369083_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_1722nt ATGGAGCTCTTCCAAGCCAAGGACCACTACATCCTGCAGCAGGGCGAGCGCGCGCTGTGGTGCAGCCGCCGCGACGGCGGCCTCCAGCTC CGACCCGACAGAGATTACTGCAGTTTATGTGACAAGCAGCCAATCGGGAGGCTGCTTTTCCGGCAGTTTTGTGAAACCAGGCCTGGGCTG GAGTGTTACATTCAGTTCCTGGACTCCGTGGCAGAATATGAAGTTACTCCAGATGAAAAACTGGGAGAGAAAGGGAAGGAAATTATGACC AAGTACCTCACCCCAAAGTCCCCTGTTTTCATAGCCCAAGTTGGCCAAGACCTGGTCTCCCAGACGGAGGAGAAGCTCCTACAGAAGCCG TGCAAAGAACTCTTTTCTGCCTGTGCACAGTCTGTCCACGAGTACCTGAGGGGAGAACCATTCCACGAATATCTGGACAGCATGTTTTTT GACCGCTTTCTCCAGTGGAAGTGGTTGGAAAGGCAACCGGTGACCAAAAACACTTTCAGGCAGTATCGAGTGCTAGGAAAAGGGGGCTTC GGGGAGGTCTGTGCCTGCCAGGTTCGGGCCACGGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGAAGAGGATCAAAAAGAGGAAAGGG GAGTCCATGGCCCTCAATGAGAAGCAGATCCTCGAGAAGGTCAACAGTCAGTTTGTGGTCAACCTGGCCTATGCCTACGAGACCAAGGAT GCACTGTGCTTGGTCCTGACCATCATGAATGGGGGTGACCTGAAGTTCCACATCTACAACATGGGCAACCCTGGCTTCGAGGAGGAGCGG GCCTTGTTTTATGCGGCAGAGATCCTCTGCGGCTTAGAAGACCTCCACCGTGAGAACACCGTCTACCGAGATCTGAAACCTGAAAACATC CTGTTAGATGATTATGGCCACATTAGGATCTCAGACCTGGGCTTGGCTGTGAAGATCCCCGAGGGAGACCTGATCCGCGGCCGGGTGGGC ACTGTTGGCTACATGGCTCCAGAGGTCCTGAACAACCAGAGGTACGGCCTGAGCCCCGACTACTGGGGCCTTGGCTGCCTCATCTATGAG ATGATCGAGGGCCAGTCGCCGTTCCGCGGCCGCAAGGAGAAGGTGAAGCGGGAGGAGGTGGACCGCCGGGTCCTGGAGACGGAGGAGGTG TACTCCCACAAGTTCTCCGAGGAGGCCAAGTCCATCTGCAAGATGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAG GGGGCTGCAGAGGTCAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCA GACCCCCGCGCTGTGTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGAC TTCTACTCCAAGTTCTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTT GGACCTAATGGTACCCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGG CAGCATCAGAACAATTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACC >In-frame_INPP5F_ENST00000361976_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_1722nt ATGGAGCTCTTCCAAGCCAAGGACCACTACATCCTGCAGCAGGGCGAGCGCGCGCTGTGGTGCAGCCGCCGCGACGGCGGCCTCCAGCTC CGACCCGACAGAGATTACTGCAGTTTATGTGACAAGCAGCCAATCGGGAGGCTGCTTTTCCGGCAGTTTTGTGAAACCAGGCCTGGGCTG GAGTGTTACATTCAGTTCCTGGACTCCGTGGCAGAATATGAAGTTACTCCAGATGAAAAACTGGGAGAGAAAGGGAAGGAAATTATGACC AAGTACCTCACCCCAAAGTCCCCTGTTTTCATAGCCCAAGTTGGCCAAGACCTGGTCTCCCAGACGGAGGAGAAGCTCCTACAGAAGCCG TGCAAAGAACTCTTTTCTGCCTGTGCACAGTCTGTCCACGAGTACCTGAGGGGAGAACCATTCCACGAATATCTGGACAGCATGTTTTTT GACCGCTTTCTCCAGTGGAAGTGGTTGGAAAGGCAACCGGTGACCAAAAACACTTTCAGGCAGTATCGAGTGCTAGGAAAAGGGGGCTTC GGGGAGGTCTGTGCCTGCCAGGTTCGGGCCACGGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGAAGAGGATCAAAAAGAGGAAAGGG GAGTCCATGGCCCTCAATGAGAAGCAGATCCTCGAGAAGGTCAACAGTCAGTTTGTGGTCAACCTGGCCTATGCCTACGAGACCAAGGAT GCACTGTGCTTGGTCCTGACCATCATGAATGGGGGTGACCTGAAGTTCCACATCTACAACATGGGCAACCCTGGCTTCGAGGAGGAGCGG GCCTTGTTTTATGCGGCAGAGATCCTCTGCGGCTTAGAAGACCTCCACCGTGAGAACACCGTCTACCGAGATCTGAAACCTGAAAACATC CTGTTAGATGATTATGGCCACATTAGGATCTCAGACCTGGGCTTGGCTGTGAAGATCCCCGAGGGAGACCTGATCCGCGGCCGGGTGGGC ACTGTTGGCTACATGGCTCCAGAGGTCCTGAACAACCAGAGGTACGGCCTGAGCCCCGACTACTGGGGCCTTGGCTGCCTCATCTATGAG ATGATCGAGGGCCAGTCGCCGTTCCGCGGCCGCAAGGAGAAGGTGAAGCGGGAGGAGGTGGACCGCCGGGTCCTGGAGACGGAGGAGGTG TACTCCCACAAGTTCTCCGAGGAGGCCAAGTCCATCTGCAAGATGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAG GGGGCTGCAGAGGTCAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCA GACCCCCGCGCTGTGTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGAC TTCTACTCCAAGTTCTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTT GGACCTAATGGTACCCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGG CAGCATCAGAACAATTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_INPP5F_ENST00000369083_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_2440nt TCTCCTCCTACCGGTCGGGTGCCCCGGGGCGTTCCCTCTGCCGCTGCTTCTCGGCGCGGTTCCTACCCGGCCGCTCCCCGAGGCGCGGGC TCTGGCGGCCTCGACCGACTAGGACGCCCCGTGCGCCGCCCGCGGGCCGCCGCCTCCCTGGGCGCGCGGGGCCAGCATGGAGCTCTTCCA AGCCAAGGACCACTACATCCTGCAGCAGGGCGAGCGCGCGCTGTGGTGCAGCCGCCGCGACGGCGGCCTCCAGCTCCGACCCGACAGAGA TTACTGCAGTTTATGTGACAAGCAGCCAATCGGGAGGCTGCTTTTCCGGCAGTTTTGTGAAACCAGGCCTGGGCTGGAGTGTTACATTCA GTTCCTGGACTCCGTGGCAGAATATGAAGTTACTCCAGATGAAAAACTGGGAGAGAAAGGGAAGGAAATTATGACCAAGTACCTCACCCC AAAGTCCCCTGTTTTCATAGCCCAAGTTGGCCAAGACCTGGTCTCCCAGACGGAGGAGAAGCTCCTACAGAAGCCGTGCAAAGAACTCTT TTCTGCCTGTGCACAGTCTGTCCACGAGTACCTGAGGGGAGAACCATTCCACGAATATCTGGACAGCATGTTTTTTGACCGCTTTCTCCA GTGGAAGTGGTTGGAAAGGCAACCGGTGACCAAAAACACTTTCAGGCAGTATCGAGTGCTAGGAAAAGGGGGCTTCGGGGAGGTCTGTGC CTGCCAGGTTCGGGCCACGGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGAAGAGGATCAAAAAGAGGAAAGGGGAGTCCATGGCCCT CAATGAGAAGCAGATCCTCGAGAAGGTCAACAGTCAGTTTGTGGTCAACCTGGCCTATGCCTACGAGACCAAGGATGCACTGTGCTTGGT CCTGACCATCATGAATGGGGGTGACCTGAAGTTCCACATCTACAACATGGGCAACCCTGGCTTCGAGGAGGAGCGGGCCTTGTTTTATGC GGCAGAGATCCTCTGCGGCTTAGAAGACCTCCACCGTGAGAACACCGTCTACCGAGATCTGAAACCTGAAAACATCCTGTTAGATGATTA TGGCCACATTAGGATCTCAGACCTGGGCTTGGCTGTGAAGATCCCCGAGGGAGACCTGATCCGCGGCCGGGTGGGCACTGTTGGCTACAT GGCTCCAGAGGTCCTGAACAACCAGAGGTACGGCCTGAGCCCCGACTACTGGGGCCTTGGCTGCCTCATCTATGAGATGATCGAGGGCCA GTCGCCGTTCCGCGGCCGCAAGGAGAAGGTGAAGCGGGAGGAGGTGGACCGCCGGGTCCTGGAGACGGAGGAGGTGTACTCCCACAAGTT CTCCGAGGAGGCCAAGTCCATCTGCAAGATGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGT CAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGT GTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTT CTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTAC CCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAA TTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTT TCGGCTCTGGCCTCCAAGTCCACAGTGGAACCAGCCCAGACCCTTCTCCTTAGAAGTGGAAGTAGTGGAGCCCCTGCTCTGGTGGGGCTG CCAGGGGAGACCCCGGGAGCCGGGGAAGGAGGCCGTCCATCCCGTCGACGTAGAACCTCGAGGTTTCTCAAAGAAATTTCCACTCAGGTC TGTTTTCCGAGGCGGCCCCGGCCGGGGTGGATTGGATTTGTCTTTGGTGAACATTGCAATAGAAATCCAATTGGATACGACAACTTGCAC GTATTTTAATAGCGTCATAACTAGAACTGAATTTTGTCTTTATGATTTTTAAAGAAAAGTTTTGTAAATTTCTCTACTGTCTCAGTTTAC ATTTTGTATATTTGTATTTAAATGAAAGTGAGACTTTGAGGGTGTATATTTTCTGTGCAGCCACTGTTAAGCCATGTGTTCCAAGGCATT TTAGCGGGGAGGGGGTTATCAAAAAAAAAAAAATGTGACTCAAGACTTCCAGAGCCTCAAATGAGAAAATGTCTTTATTAAATGTAGAAA >In-frame_INPP5F_ENST00000361976_chr10_121485871_+_GRK5_ENST00000392870_chr10_121140327_+_2440nt TCTCCTCCTACCGGTCGGGTGCCCCGGGGCGTTCCCTCTGCCGCTGCTTCTCGGCGCGGTTCCTACCCGGCCGCTCCCCGAGGCGCGGGC TCTGGCGGCCTCGACCGACTAGGACGCCCCGTGCGCCGCCCGCGGGCCGCCGCCTCCCTGGGCGCGCGGGGCCAGCATGGAGCTCTTCCA AGCCAAGGACCACTACATCCTGCAGCAGGGCGAGCGCGCGCTGTGGTGCAGCCGCCGCGACGGCGGCCTCCAGCTCCGACCCGACAGAGA TTACTGCAGTTTATGTGACAAGCAGCCAATCGGGAGGCTGCTTTTCCGGCAGTTTTGTGAAACCAGGCCTGGGCTGGAGTGTTACATTCA GTTCCTGGACTCCGTGGCAGAATATGAAGTTACTCCAGATGAAAAACTGGGAGAGAAAGGGAAGGAAATTATGACCAAGTACCTCACCCC AAAGTCCCCTGTTTTCATAGCCCAAGTTGGCCAAGACCTGGTCTCCCAGACGGAGGAGAAGCTCCTACAGAAGCCGTGCAAAGAACTCTT TTCTGCCTGTGCACAGTCTGTCCACGAGTACCTGAGGGGAGAACCATTCCACGAATATCTGGACAGCATGTTTTTTGACCGCTTTCTCCA GTGGAAGTGGTTGGAAAGGCAACCGGTGACCAAAAACACTTTCAGGCAGTATCGAGTGCTAGGAAAAGGGGGCTTCGGGGAGGTCTGTGC CTGCCAGGTTCGGGCCACGGGTAAAATGTATGCCTGCAAGCGCTTGGAGAAGAAGAGGATCAAAAAGAGGAAAGGGGAGTCCATGGCCCT CAATGAGAAGCAGATCCTCGAGAAGGTCAACAGTCAGTTTGTGGTCAACCTGGCCTATGCCTACGAGACCAAGGATGCACTGTGCTTGGT CCTGACCATCATGAATGGGGGTGACCTGAAGTTCCACATCTACAACATGGGCAACCCTGGCTTCGAGGAGGAGCGGGCCTTGTTTTATGC GGCAGAGATCCTCTGCGGCTTAGAAGACCTCCACCGTGAGAACACCGTCTACCGAGATCTGAAACCTGAAAACATCCTGTTAGATGATTA TGGCCACATTAGGATCTCAGACCTGGGCTTGGCTGTGAAGATCCCCGAGGGAGACCTGATCCGCGGCCGGGTGGGCACTGTTGGCTACAT GGCTCCAGAGGTCCTGAACAACCAGAGGTACGGCCTGAGCCCCGACTACTGGGGCCTTGGCTGCCTCATCTATGAGATGATCGAGGGCCA GTCGCCGTTCCGCGGCCGCAAGGAGAAGGTGAAGCGGGAGGAGGTGGACCGCCGGGTCCTGGAGACGGAGGAGGTGTACTCCCACAAGTT CTCCGAGGAGGCCAAGTCCATCTGCAAGATGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGT CAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGT GTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTT CTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTAC CCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAA TTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTT TCGGCTCTGGCCTCCAAGTCCACAGTGGAACCAGCCCAGACCCTTCTCCTTAGAAGTGGAAGTAGTGGAGCCCCTGCTCTGGTGGGGCTG CCAGGGGAGACCCCGGGAGCCGGGGAAGGAGGCCGTCCATCCCGTCGACGTAGAACCTCGAGGTTTCTCAAAGAAATTTCCACTCAGGTC TGTTTTCCGAGGCGGCCCCGGCCGGGGTGGATTGGATTTGTCTTTGGTGAACATTGCAATAGAAATCCAATTGGATACGACAACTTGCAC GTATTTTAATAGCGTCATAACTAGAACTGAATTTTGTCTTTATGATTTTTAAAGAAAAGTTTTGTAAATTTCTCTACTGTCTCAGTTTAC ATTTTGTATATTTGTATTTAAATGAAAGTGAGACTTTGAGGGTGTATATTTTCTGTGCAGCCACTGTTAAGCCATGTGTTCCAAGGCATT TTAGCGGGGAGGGGGTTATCAAAAAAAAAAAAATGTGACTCAAGACTTCCAGAGCCTCAAATGAGAAAATGTCTTTATTAAATGTAGAAA |
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FusionGenePPI for INPP5F_GRK5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
INPP5F | YWHAB | GRK5 | CALM1, CAV1, AGTR1, AVPR1A, AVPR2, TACR1, SNCA, SNCB, SNCG, RCVRN, GRK5, RHO, CABP1, SRRM2, FRYL, SPTAN1, MYH9, MYH10, SPTBN1, CKAP5, NCL, DDB1, AP3D1, OTUD4, CWC22, HSP90AB1, HSP90AA1, UBTF, PNN, DHX9, AFF4, DCAF5, HNRNPU, KPNB1, DHX30, CUL4B, EIF3A, GYS1, KANK2, NAT10, MMS19, DHX15, PPIG, ILF3, AP2A1, MYO1C, SRPK1, ACIN1, EEF2, HDAC6, USP15, HSPA4, PSMD2, CAND2, FTSJ3, TCOF1, KANK1, GLG1, EFTUD2, MAP4, PPP6R3, BCLAF1, GEMIN4, ABCF1, XRCC5, SIN3A, MADD, ANKFY1, STK38, TAB1, GRWD1, AKT2, PSMC1, GOT1L1, DLST, MYCN, CALR, SPIN1, GINS4, ALYREF, COPS7A, YWHAG, CLIC1, SAP18, LYZ, ARF1, PRKDC, MYO9B, DOCK4, USP9X, AP3B1, NOLC1, LRPPRC, BAZ1A, UBE2O, NCBP1, JUP, RAB11FIP5, FAM120A, DDX21, BCR, FMNL2, PNPLA6, RANBP9, LARP1, SRRM1, ABI3BP, U2SURP, SKIV2L2, SMARCA1, AP2A2, CTDP1, MAP4K4, PPFIBP1, MYBBP1A, BMS1, DAXX, USP47, SPATA31A7, RPL4, AP3M1, RPL3, PPP2R2A, EEF1A1, EIF4A3, COPS4, OLA1, HADHB, CDC37, LYAR, COPS2, EIF2S3, MAEA, PSMD11, AP3M2, WDR12, PIP4K2A, NR2F1, PSMC6, TOR4A, RBMS1, MRPS27, KCMF1, NAF1, MAT2A, PSMC2, TBL2, NFIB, TUFM, RUVBL1, YWHAQ, YWHAZ, SRSF1, YWHAB, KCTD5, C1QBP, MRTO4, SPIN3, WDR82, CFL1, ARF4, SKP1, PIP, TNFAIP8L1, CUL4A, DDB2, RBX1, TBXA2R, MOV10, NXF1, GRK6, ADRB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | GRK5 | chr10:121485871 | chr10:121140327 | ENST00000392870 | + | 1 | 16 | 20_39 | 49 | 591 | calmodulin |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INPP5F_GRK5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INPP5F_GRK5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GRK5 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Tgene | GRK5 | C0023895 | Liver diseases | 1 | CTD_human |
Tgene | GRK5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | GRK5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |