FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1752

FusionGeneSummary for ANKRD10_CPNE4

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD10_CPNE4
Fusion gene ID: 1752
HgeneTgene
Gene symbol

ANKRD10

CPNE4

Gene ID

55608

131034

Gene nameankyrin repeat domain 10copine 4
Synonyms-COPN4|CPN4
Cytomap

13q34

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 10copine-4copine 8copine IV
Modification date2018051920180523
UniProtAcc

Q9NXR5

Q96A23

Ensembl transtripts involved in fusion geneENST00000267339, ENST00000375758, 
ENST00000489973, ENST00000310847, 
ENST00000512055, ENST00000429747, 
ENST00000512332, ENST00000511604, 
ENST00000502818, ENST00000503204, 
Fusion gene scores* DoF score6 X 5 X 2=6010 X 7 X 5=350
# samples 610
** MAII scorelog2(6/60*10)=0log2(10/350*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD10 [Title/Abstract] AND CPNE4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE005082ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000267339ENST00000512055ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000267339ENST00000429747ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000267339ENST00000512332ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000267339ENST00000511604ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000267339ENST00000502818ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000267339ENST00000503204ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000512055ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000429747ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000512332ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000511604ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000502818ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000375758ENST00000503204ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000512055ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000429747ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000512332ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000511604ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000502818ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000489973ENST00000503204ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000512055ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000429747ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000512332ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000511604ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000502818ANKRD10chr13

111535715

-CPNE4chr3

131804259

+
intron-intronENST00000310847ENST00000503204ANKRD10chr13

111535715

-CPNE4chr3

131804259

+

Top

FusionProtFeatures for ANKRD10_CPNE4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD10

Q9NXR5

CPNE4

Q96A23

Probable calcium-dependent phospholipid-binding proteinthat may play a role in calcium-mediated intracellular processes.{ECO:0000250|UniProtKB:Q99829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANKRD10_CPNE4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANKRD10_CPNE4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANKRD10_CPNE4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANKRD10_CPNE4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource