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Fusion gene ID: 17506 |
FusionGeneSummary for INPP5A_FAM149B1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INPP5A_FAM149B1 | Fusion gene ID: 17506 | Hgene | Tgene | Gene symbol | INPP5A | FAM149B1 | Gene ID | 3632 | 317662 |
| Gene name | inositol polyphosphate-5-phosphatase A | family with sequence similarity 149 member B1 | |
| Synonyms | 5PTASE | KIAA0974 | |
| Cytomap | 10q26.3 | 10q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | type I inositol 1,4,5-trisphosphate 5-phosphatase43 kDa inositol polyphosphate 5-phophataseCTCL tumor antigen HD-CL-02InsP3 5-phosphataseinositol polyphosphate-5-phosphatase, 40kDinositol polyphosphate-5-phosphatase, 40kDainositol trisphosphate-5-ph | protein FAM149B1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14642 | Q96BN6 | |
| Ensembl transtripts involved in fusion gene | ENST00000368594, ENST00000368593, ENST00000487614, | ENST00000242505, ENST00000607940, | |
| Fusion gene scores | * DoF score | 11 X 6 X 8=528 | 4 X 4 X 4=64 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INPP5A [Title/Abstract] AND FAM149B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A03P-01A | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368594 | ENST00000242505 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| 5CDS-intron | ENST00000368594 | ENST00000607940 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| In-frame | ENST00000368593 | ENST00000242505 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| 5CDS-intron | ENST00000368593 | ENST00000607940 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| intron-3CDS | ENST00000487614 | ENST00000242505 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
| intron-intron | ENST00000487614 | ENST00000607940 | INPP5A | chr10 | 134563349 | + | FAM149B1 | chr10 | 74999070 | + |
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FusionProtFeatures for INPP5A_FAM149B1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INPP5A | FAM149B1 |
| Major isoenzyme hydrolyzing the calcium-mobilizingsecond messenger Ins(1,4,5)P3, this is a signal-terminatingreaction. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INPP5A_FAM149B1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_INPP5A_ENST00000368594_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_350aa MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRE >In-frame_INPP5A_ENST00000368593_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_350aa MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_INPP5A_ENST00000368594_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_1050nt ATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAG AAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAAC TACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTAC CTGGATGAAAACTACAAATCCCAGGAGCACTTCACGGCACTAGGAAGCTTTTATTTTCTTCATGAGTCCTTAAAAAACATCTACCAGTTT GACTTTAAAGCTAAGAAGTATAGAAAGGTCGCTGGCAAAGAGATCTACTCGGATACCTTAGAGAGCACGCCCATGCTGGAGAAGGAGAAG TTTCCGCAGGACTACTTCCCCGAGTGCAAATGGTCAAGAAAAGGCTTCATCCGGACGAGGTGGTGCATTGCAGACTGTGCCTTTGACTTG GTGAATATCCATCTTTTCCATGATGCTTCCAATCTGGTCGCCTGGGAAACAAGCCCTTCCGTGTACTCGGGAATCCGGCACAAGGCACTG GGCTACGTGCTGGACAGAATCATTGATCAGCGATTCGAGAAGGTTTCCTACTTTGTATTTGGTGATTTCAACTTCCGGCTGGATTCCAAG TCCGTCGTGGAGACGCTCTGCACAAAAGCCACCATGCAGACGGTCCGGGCCGCCGACACCAATGAAGTGGTGAAGCTCATATTTCGTGAG TCGGACAACGACCGGAAGGTTATGCTCCAGTTAGAAAAGAAACTCTTCGACTACTTCAACCAGGAGGTTTTCCGAGACAACAACGGCACC GCGCTGGATACACAGTATCGTCGCTCATGTGCAGTTGAGTATCCTCATCAGGCCCGACCTGGCAGGGGATCTGCAGGTCCTCAGTTACAT >In-frame_INPP5A_ENST00000368593_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_1050nt ATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAG AAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAAC TACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTAC CTGGATGAAAACTACAAATCCCAGGAGCACTTCACGGCACTAGGAAGCTTTTATTTTCTTCATGAGTCCTTAAAAAACATCTACCAGTTT GACTTTAAAGCTAAGAAGTATAGAAAGGTCGCTGGCAAAGAGATCTACTCGGATACCTTAGAGAGCACGCCCATGCTGGAGAAGGAGAAG TTTCCGCAGGACTACTTCCCCGAGTGCAAATGGTCAAGAAAAGGCTTCATCCGGACGAGGTGGTGCATTGCAGACTGTGCCTTTGACTTG GTGAATATCCATCTTTTCCATGATGCTTCCAATCTGGTCGCCTGGGAAACAAGCCCTTCCGTGTACTCGGGAATCCGGCACAAGGCACTG GGCTACGTGCTGGACAGAATCATTGATCAGCGATTCGAGAAGGTTTCCTACTTTGTATTTGGTGATTTCAACTTCCGGCTGGATTCCAAG TCCGTCGTGGAGACGCTCTGCACAAAAGCCACCATGCAGACGGTCCGGGCCGCCGACACCAATGAAGTGGTGAAGCTCATATTTCGTGAG TCGGACAACGACCGGAAGGTTATGCTCCAGTTAGAAAAGAAACTCTTCGACTACTTCAACCAGGAGGTTTTCCGAGACAACAACGGCACC GCGCTGGATACACAGTATCGTCGCTCATGTGCAGTTGAGTATCCTCATCAGGCCCGACCTGGCAGGGGATCTGCAGGTCCTCAGTTACAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_INPP5A_ENST00000368594_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_4812nt GGAACTTTCCCAGCGGATCTAATGGCTGCGCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCG AGCGAGCGAGCGCGAGGCCGGAGCCCCGGCCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTG ACGCCCCGCGGCCCCGCGAAGACCCCGGCCGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCC GGGCACCATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAA CCTGCAGAAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGG GAAGAACTACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCG AGTCTACCTGGATGAAAACTACAAATCCCAGGAGCACTTCACGGCACTAGGAAGCTTTTATTTTCTTCATGAGTCCTTAAAAAACATCTA CCAGTTTGACTTTAAAGCTAAGAAGTATAGAAAGGTCGCTGGCAAAGAGATCTACTCGGATACCTTAGAGAGCACGCCCATGCTGGAGAA GGAGAAGTTTCCGCAGGACTACTTCCCCGAGTGCAAATGGTCAAGAAAAGGCTTCATCCGGACGAGGTGGTGCATTGCAGACTGTGCCTT TGACTTGGTGAATATCCATCTTTTCCATGATGCTTCCAATCTGGTCGCCTGGGAAACAAGCCCTTCCGTGTACTCGGGAATCCGGCACAA GGCACTGGGCTACGTGCTGGACAGAATCATTGATCAGCGATTCGAGAAGGTTTCCTACTTTGTATTTGGTGATTTCAACTTCCGGCTGGA TTCCAAGTCCGTCGTGGAGACGCTCTGCACAAAAGCCACCATGCAGACGGTCCGGGCCGCCGACACCAATGAAGTGGTGAAGCTCATATT TCGTGAGTCGGACAACGACCGGAAGGTTATGCTCCAGTTAGAAAAGAAACTCTTCGACTACTTCAACCAGGAGGTTTTCCGAGACAACAA CGGCACCGCGCTGGATACACAGTATCGTCGCTCATGTGCAGTTGAGTATCCTCATCAGGCCCGACCTGGCAGGGGATCTGCAGGTCCTCA GTTACATGGGTCTACAAAATCTCAAAGCGGAGGCAGACCAGTCTCTCGAACCAGGCAGGGACCATAAGGCAAATGAGAAGAATCTATCAG GCTGCAGGAAACACGAGATTTCATGAAGCAGTATTCAGTCATCAAGTGATGCAGAGCTTGTATAGAAGATCGACTAGAAATCATCTTCAT GAAGAGTGATTTTGGCACAAGTGACCGAAGAACAAAACACCATAGCAGCCAAAAATGACATGAGTGTTGTTTCTATCTCCAGTTACTGTC TCTTTCAGCAGAAATTAACCTATCCCATTGGAAAGGCAAGTTTGTACCCAAAGATGCAACAGTGAATAATACCCAAATCACTGCTCATGT TATCTCTTAACAATGATCAGTTCAATCATATAGGATTTGATGAGCTCACACATACACAAAAAGCAGCAAATCATCAGTGACAATATCACT GGCTTCAGAATACTTCAGCCTGTGTTCATTTCTGGAGAGTTGTACTCAGTTTTAAGTCATTTTGCTGTTGAAAATCTGACCTCATCAAAT AGATGTCATTCCTAAAACTCTCTTTAGATGTCCTACCCTATCAGCAGATTAAAATGGAAGGGGTGTGTAACTAAAAACATAAATGTTAAG CATTAGTATAAAGTAACTTCTGTAATAAATTATATCGCATATTTTTTCAGATAGGACAGCTCAACCTTACGATGCCTACCTGATGCCAGG TGATGCTTATTTTCTTCCTAAAGTAGGTTACTGGTCATATCTTTTTTCCAAATATTAAATGCACCTTGCCAGATATTCTCCTGCAGCTCT AAGGAAAGGAAATCAATTTAAAAATAATTTGTAGAATCTACTATTGAGCCACCAAAGTATAATTCCCTAAAAGTTTAAGAAACCCTGGCA ATTAATTCAGCATAAACATATCCTATAAACAGCAGGAGAGGTTCAGCTTTCTGATTTTACTGTGGACCTTTTCCTAAGGGCATTCATGAA TGCAGCAACAGTTTTAACTATGGCTTACATTTATTTTAAATTTCACTAAATACAAATCTTGATTGTCATGCCAGTTTTAGATCTTATTAA TTTTCAGAATGGATAAATTCAAATAATCATAAATTACGGTAACTTTTTATTATACCAAGGTGTTCTAATGCCATCATATGAAGACAGATG CTTCAAACAACCTGCATTAAATTATATTTTTAATAAAATTAAAATCTATTTTTAACCTATTTGTAGTCACAAACCGAAAACGTGTCGTCT TTACCTTAGAGCTAAAGGCTTACTTTATGCATACGGTATATTTAATAGTCTACAAATCAAAGATTTAAACAGTCCCTTAAAAATTCCATA TATTCTCATACCAACTCATCTACATAGAAATGAAAATCTCTATTGTTCTCACAAACCATTACCATGAGTTCACTATAACAACTGGATCAA TATGGCTTGCCTTTCAAAGTTAAAGAATCAGAAAGGGGCCTGTAAGAAGTCATTTAGCCCAATTCCCTCACCCTGTGTGTTTTCCCTCAA AGCCAGTGCAATTTTTTTTTAACCAAAAAACTGGACATGTTTAATACATACAGTTTGACAAATTTGGATTTCACTCTTTGTTTTGATGTA GTAACTCTTTTATAAAAGGGAACAGATTCAGACAAGCTCAGTGGCCCAACTGAAGACATTCAGCAATTAATGGCAGGACTTCAGTAATCA GTGGCAGGACTACAACATACATCTCTTCATGCTAGGGAAACCAGGCTCTCTATTATAAAGCTGACCAGGGCTATTGTTTTCCCCTTTTCT CTCATCCTAAACACCATTCATATTTTTCCTAGGTCACATTTTAGTGGGATCATTTACAAAGCCCCCAGAACTTAATCATCATGTTTTACC TTTTTTATTGAATTATATACACCTCTTACAAAAATGCTTGAAGTAATTTAACACCTGTACATCAGTACAAAACCTGGCTGAGTAAAATGA AGAGAGGATCTATTCAAGATCATTAAGACCAAATGTAAACTGGGAAGTATGTGGAAGATAGCTGTCCAGCAAGTGTCTGGAAGGTGTTCT AGCTGGGTAGAGAGCCTATTCTAACAGACACGCACATCGCAGAAAGCAGCATGAACAGAACCACATCCTAGATAAGAGTTCTGTGTACAG AAGATCCATGGAGGCAAGTGCTGTCAGGAAGGACACTGCCTCCCTCCACCCTCCCAAATGTCACCACCAAGTTCCTTCAGGTGAGACCTC ACACAATGTCAAGTGCTTTCTAGGAAATACTAAGATCAGGTTGAGAGATTCTGCTTGGTCTAGTCAATCTGAAAAATTCAGGCTGGAAAG ACACCTTTTCTCAAGAGCTGAATTGACTTTTGCCTTCAAATCCTGCCTGCACCTTGCCTACGATGGCATCAATTTACACCTAAGGACCTT TGAAGAGAAAAATTCCATTATTTCTTTTCTTTCTTGAGAGCAGATTTTTTCCCTCCTCCTTTGGAAGATTTGCAGTACTTTGCTTCCATC TGAGCCAGAAAATTGTCCATTTCCTTTTGCCGATCCTTTTGTCTGCTCTGTTTGAGAAGTTAAAACACAAGCTTTCACAACATTATCCAT AGACAGAAAGTACCTAGTGGTTGCCAGGGGCTGGAAAAGTGGAATAACTACTAATGGGTATGGAGTTTTTTTGGAATGGTGAAAATGTCC TACAATTGGTGTTAATAATTGTAAAACTTTGTAAATACACTTAAAACCACCAAATTGTACACTTTAAAAGGACAAATAGAAGGTATGCGG TTATGTCTTAAAAGAAGAAAACAAAATACAACATTCCAAAGAAAATATTAGCAGTAGGAATCAGATCATTAAAGATGTGGCAACAAACTG CCAAGTTTACCTGAATGGCTGCCTTCAGGCTATCCACGCCTTCATCAAGCCCCAACTCCTTTCTGCTCATTTCTGCTTCTTTGGCCTCTT CCTGAGCCTGAAACAGGAACTCACATGAGACTCAGGGCCACCAGGAAATGCTTAAAATACATACTCTTTCCCAAAAGCAAATCTATAATT CTGTTTCAATTTTATGAATATATGAATAGACAAAATGAATCGAATTACATAACTATGTCATTCATTAAATGGCAACAATGCTGACAGCAA GCAGTAGATCCTCTGATTCCAATTACCATTTGTTTTTTACCCAATTCTATTTGCTAGAGGTAGTAAGTACTCTGGCACTCATAAATCACA TGATGATAAAAAGGAACATGAGGCCGGGTATGGTGGCTCACAACTGTAATCCCCATACCTTGGGAGGCCAAGGTGGGAGGATCACTTGAA CTCAGGAGTTCAAGACCTGCCTGGGTAACATAGTGAGACCTCAGTTCTATAAAAAAGAAAAGAAATGAGCCTGGTGTGGTGGCATGTGCT TGTAGTCCCAGCTACTAGGGAGGCTGAGGTGGGAAGATGGCTTCAGTCTGAGAGTTCAGGCTGCAATAAGCTGTGATCATGCCTCTGCAC >In-frame_INPP5A_ENST00000368593_chr10_134563349_+_FAM149B1_ENST00000242505_chr10_74999070_+_4783nt GCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCGAGCGAGCGAGCGCGAGGCCGGAGCCCCGG CCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTGACGCCCCGCGGCCCCGCGAAGACCCCGGC CGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCCGGGCACCATGGCGGGGAAGGCGGCCGCCC CGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAGAAGAACTGGCTTCGGGAATTTT ACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAACTACGAGGCCTCCATGTCCCACG TGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTACCTGGATGAAAACTACAAATCCC AGGAGCACTTCACGGCACTAGGAAGCTTTTATTTTCTTCATGAGTCCTTAAAAAACATCTACCAGTTTGACTTTAAAGCTAAGAAGTATA GAAAGGTCGCTGGCAAAGAGATCTACTCGGATACCTTAGAGAGCACGCCCATGCTGGAGAAGGAGAAGTTTCCGCAGGACTACTTCCCCG AGTGCAAATGGTCAAGAAAAGGCTTCATCCGGACGAGGTGGTGCATTGCAGACTGTGCCTTTGACTTGGTGAATATCCATCTTTTCCATG ATGCTTCCAATCTGGTCGCCTGGGAAACAAGCCCTTCCGTGTACTCGGGAATCCGGCACAAGGCACTGGGCTACGTGCTGGACAGAATCA TTGATCAGCGATTCGAGAAGGTTTCCTACTTTGTATTTGGTGATTTCAACTTCCGGCTGGATTCCAAGTCCGTCGTGGAGACGCTCTGCA CAAAAGCCACCATGCAGACGGTCCGGGCCGCCGACACCAATGAAGTGGTGAAGCTCATATTTCGTGAGTCGGACAACGACCGGAAGGTTA TGCTCCAGTTAGAAAAGAAACTCTTCGACTACTTCAACCAGGAGGTTTTCCGAGACAACAACGGCACCGCGCTGGATACACAGTATCGTC GCTCATGTGCAGTTGAGTATCCTCATCAGGCCCGACCTGGCAGGGGATCTGCAGGTCCTCAGTTACATGGGTCTACAAAATCTCAAAGCG GAGGCAGACCAGTCTCTCGAACCAGGCAGGGACCATAAGGCAAATGAGAAGAATCTATCAGGCTGCAGGAAACACGAGATTTCATGAAGC AGTATTCAGTCATCAAGTGATGCAGAGCTTGTATAGAAGATCGACTAGAAATCATCTTCATGAAGAGTGATTTTGGCACAAGTGACCGAA GAACAAAACACCATAGCAGCCAAAAATGACATGAGTGTTGTTTCTATCTCCAGTTACTGTCTCTTTCAGCAGAAATTAACCTATCCCATT GGAAAGGCAAGTTTGTACCCAAAGATGCAACAGTGAATAATACCCAAATCACTGCTCATGTTATCTCTTAACAATGATCAGTTCAATCAT ATAGGATTTGATGAGCTCACACATACACAAAAAGCAGCAAATCATCAGTGACAATATCACTGGCTTCAGAATACTTCAGCCTGTGTTCAT TTCTGGAGAGTTGTACTCAGTTTTAAGTCATTTTGCTGTTGAAAATCTGACCTCATCAAATAGATGTCATTCCTAAAACTCTCTTTAGAT GTCCTACCCTATCAGCAGATTAAAATGGAAGGGGTGTGTAACTAAAAACATAAATGTTAAGCATTAGTATAAAGTAACTTCTGTAATAAA TTATATCGCATATTTTTTCAGATAGGACAGCTCAACCTTACGATGCCTACCTGATGCCAGGTGATGCTTATTTTCTTCCTAAAGTAGGTT ACTGGTCATATCTTTTTTCCAAATATTAAATGCACCTTGCCAGATATTCTCCTGCAGCTCTAAGGAAAGGAAATCAATTTAAAAATAATT TGTAGAATCTACTATTGAGCCACCAAAGTATAATTCCCTAAAAGTTTAAGAAACCCTGGCAATTAATTCAGCATAAACATATCCTATAAA CAGCAGGAGAGGTTCAGCTTTCTGATTTTACTGTGGACCTTTTCCTAAGGGCATTCATGAATGCAGCAACAGTTTTAACTATGGCTTACA TTTATTTTAAATTTCACTAAATACAAATCTTGATTGTCATGCCAGTTTTAGATCTTATTAATTTTCAGAATGGATAAATTCAAATAATCA TAAATTACGGTAACTTTTTATTATACCAAGGTGTTCTAATGCCATCATATGAAGACAGATGCTTCAAACAACCTGCATTAAATTATATTT TTAATAAAATTAAAATCTATTTTTAACCTATTTGTAGTCACAAACCGAAAACGTGTCGTCTTTACCTTAGAGCTAAAGGCTTACTTTATG CATACGGTATATTTAATAGTCTACAAATCAAAGATTTAAACAGTCCCTTAAAAATTCCATATATTCTCATACCAACTCATCTACATAGAA ATGAAAATCTCTATTGTTCTCACAAACCATTACCATGAGTTCACTATAACAACTGGATCAATATGGCTTGCCTTTCAAAGTTAAAGAATC AGAAAGGGGCCTGTAAGAAGTCATTTAGCCCAATTCCCTCACCCTGTGTGTTTTCCCTCAAAGCCAGTGCAATTTTTTTTTAACCAAAAA ACTGGACATGTTTAATACATACAGTTTGACAAATTTGGATTTCACTCTTTGTTTTGATGTAGTAACTCTTTTATAAAAGGGAACAGATTC AGACAAGCTCAGTGGCCCAACTGAAGACATTCAGCAATTAATGGCAGGACTTCAGTAATCAGTGGCAGGACTACAACATACATCTCTTCA TGCTAGGGAAACCAGGCTCTCTATTATAAAGCTGACCAGGGCTATTGTTTTCCCCTTTTCTCTCATCCTAAACACCATTCATATTTTTCC TAGGTCACATTTTAGTGGGATCATTTACAAAGCCCCCAGAACTTAATCATCATGTTTTACCTTTTTTATTGAATTATATACACCTCTTAC AAAAATGCTTGAAGTAATTTAACACCTGTACATCAGTACAAAACCTGGCTGAGTAAAATGAAGAGAGGATCTATTCAAGATCATTAAGAC CAAATGTAAACTGGGAAGTATGTGGAAGATAGCTGTCCAGCAAGTGTCTGGAAGGTGTTCTAGCTGGGTAGAGAGCCTATTCTAACAGAC ACGCACATCGCAGAAAGCAGCATGAACAGAACCACATCCTAGATAAGAGTTCTGTGTACAGAAGATCCATGGAGGCAAGTGCTGTCAGGA AGGACACTGCCTCCCTCCACCCTCCCAAATGTCACCACCAAGTTCCTTCAGGTGAGACCTCACACAATGTCAAGTGCTTTCTAGGAAATA CTAAGATCAGGTTGAGAGATTCTGCTTGGTCTAGTCAATCTGAAAAATTCAGGCTGGAAAGACACCTTTTCTCAAGAGCTGAATTGACTT TTGCCTTCAAATCCTGCCTGCACCTTGCCTACGATGGCATCAATTTACACCTAAGGACCTTTGAAGAGAAAAATTCCATTATTTCTTTTC TTTCTTGAGAGCAGATTTTTTCCCTCCTCCTTTGGAAGATTTGCAGTACTTTGCTTCCATCTGAGCCAGAAAATTGTCCATTTCCTTTTG CCGATCCTTTTGTCTGCTCTGTTTGAGAAGTTAAAACACAAGCTTTCACAACATTATCCATAGACAGAAAGTACCTAGTGGTTGCCAGGG GCTGGAAAAGTGGAATAACTACTAATGGGTATGGAGTTTTTTTGGAATGGTGAAAATGTCCTACAATTGGTGTTAATAATTGTAAAACTT TGTAAATACACTTAAAACCACCAAATTGTACACTTTAAAAGGACAAATAGAAGGTATGCGGTTATGTCTTAAAAGAAGAAAACAAAATAC AACATTCCAAAGAAAATATTAGCAGTAGGAATCAGATCATTAAAGATGTGGCAACAAACTGCCAAGTTTACCTGAATGGCTGCCTTCAGG CTATCCACGCCTTCATCAAGCCCCAACTCCTTTCTGCTCATTTCTGCTTCTTTGGCCTCTTCCTGAGCCTGAAACAGGAACTCACATGAG ACTCAGGGCCACCAGGAAATGCTTAAAATACATACTCTTTCCCAAAAGCAAATCTATAATTCTGTTTCAATTTTATGAATATATGAATAG ACAAAATGAATCGAATTACATAACTATGTCATTCATTAAATGGCAACAATGCTGACAGCAAGCAGTAGATCCTCTGATTCCAATTACCAT TTGTTTTTTACCCAATTCTATTTGCTAGAGGTAGTAAGTACTCTGGCACTCATAAATCACATGATGATAAAAAGGAACATGAGGCCGGGT ATGGTGGCTCACAACTGTAATCCCCATACCTTGGGAGGCCAAGGTGGGAGGATCACTTGAACTCAGGAGTTCAAGACCTGCCTGGGTAAC ATAGTGAGACCTCAGTTCTATAAAAAAGAAAAGAAATGAGCCTGGTGTGGTGGCATGTGCTTGTAGTCCCAGCTACTAGGGAGGCTGAGG TGGGAAGATGGCTTCAGTCTGAGAGTTCAGGCTGCAATAAGCTGTGATCATGCCTCTGCACTCCAGCCTGGGTGATGGAGATGCCATCTC |
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FusionGenePPI for INPP5A_FAM149B1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| INPP5A | YWHAZ, RABGGTB, TTC1, RCCD1, ZG16B, ITFG2, IGHA1, SLC25A41, DUSP22, ISOC2, MED21, PRPS2 | FAM149B1 | TBC1D32, CFAP20 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INPP5A_FAM149B1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INPP5A_FAM149B1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | INPP5A | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | INPP5A | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | INPP5A | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | INPP5A | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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