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Fusion gene ID: 17498 |
FusionGeneSummary for INPP4B_IST1 |
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Fusion gene information | Fusion gene name: INPP4B_IST1 | Fusion gene ID: 17498 | Hgene | Tgene | Gene symbol | INPP4B | IST1 | Gene ID | 8821 | 9798 |
Gene name | inositol polyphosphate-4-phosphatase type II B | IST1, ESCRT-III associated factor | |
Synonyms | - | OLC1 | |
Cytomap | 4q31.21 | 16q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | IST1 homologIST1, endosomal sorting complex required for transport-III componentincreased sodium tolerance 1 homologoverexpressed in lung cancer 1putative MAPK-activating protein PM28 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O15327 | P53990 | |
Ensembl transtripts involved in fusion gene | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | ENST00000544564, ENST00000541571, ENST00000535424, ENST00000378799, ENST00000538565, ENST00000606369, ENST00000329908, ENST00000538850, ENST00000378798, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 4 X 3 X 3=36 |
# samples | 8 | 5 | |
** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: INPP4B [Title/Abstract] AND IST1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IST1 | GO:0009838 | abscission | 19129479|19129480 |
Tgene | IST1 | GO:0019076 | viral release from host cell | 19129479 |
Tgene | IST1 | GO:0045862 | positive regulation of proteolysis | 20849418 |
Tgene | IST1 | GO:0046745 | viral capsid secondary envelopment | 19129479 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB020243 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + | ||
ChiTaRS3.1 | AK057258 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000513000 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000513000 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000509777 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000509777 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000262992 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000262992 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000308502 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000308502 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000508116 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508116 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000507861 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000507861 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000506217 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000506217 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-3CDS | ENST00000508084 | ENST00000544564 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000541571 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000535424 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000378799 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000538565 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000606369 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000329908 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000538850 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
intron-intron | ENST00000508084 | ENST00000378798 | INPP4B | chr4 | 143687891 | - | IST1 | chr16 | 71924472 | + |
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FusionProtFeatures for INPP4B_IST1 |
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Hgene | Tgene |
INPP4B | IST1 |
Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. | ESCRT-III-like protein involved in specific functions ofthe ESCRT machinery. Is required for efficient abscission duringcytokinesis, but not for HIV-1 budding. The involvement in the MVBpathway is not established. Involved in recruiting VPS4A and/orVPS4B to the midbody of dividing cells (PubMed:19129479,PubMed:19129480). During late anaphase, involved in nuclearenvelope reassembly and mitotic spindle disassembly together withthe ESCRT-III complex: IST1 acts by mediating the recruitment ofSPAST to the nuclear membrane, leading to microtubule severing(PubMed:26040712). Regulates early endosomal tubulation togetherwith the ESCRT-III complex by mediating the recruitment of SPAST(PubMed:23897888). {ECO:0000269|PubMed:19129479,ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888,ECO:0000269|PubMed:26040712}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INPP4B_IST1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for INPP4B_IST1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INPP4B_IST1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INPP4B_IST1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |