	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 17498

FusionGeneSummary for INPP4B_IST1

Fusion gene summary

Fusion gene information	Fusion gene name: INPP4B_IST1
	Fusion gene ID: 17498
		Hgene	Tgene
	Gene symbol	INPP4B	IST1
	Gene ID	8821	9798
	Gene name	inositol polyphosphate-4-phosphatase type II B	IST1, ESCRT-III associated factor
	Synonyms	-	OLC1
	Cytomap	4q31.21	16q22.2
	Type of gene	protein-coding	protein-coding
	Description	type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa	IST1 homologIST1, endosomal sorting complex required for transport-III componentincreased sodium tolerance 1 homologoverexpressed in lung cancer 1putative MAPK-activating protein PM28
	Modification date	20180523	20180522
	UniProtAcc	O15327	P53990
	Ensembl transtripts involved in fusion gene	ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084,	ENST00000544564, ENST00000541571, ENST00000535424, ENST00000378799, ENST00000538565, ENST00000606369, ENST00000329908, ENST00000538850, ENST00000378798,
Fusion gene scores	* DoF score	7 X 7 X 3=147	4 X 3 X 3=36
	# samples	8	5
	** MAII score	log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: INPP4B [Title/Abstract] AND IST1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	IST1	GO:0009838	abscission	19129479\|19129480
Tgene	IST1	GO:0019076	viral release from host cell	19129479
Tgene	IST1	GO:0045862	positive regulation of proteolysis	20849418
Tgene	IST1	GO:0046745	viral capsid secondary envelopment	19129479

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DB020243	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
ChiTaRS3.1			AK057258	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000513000	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000513000	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000509777	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000509777	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000262992	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000262992	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000308502	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000308502	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000508116	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508116	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000507861	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000507861	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000506217	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000506217	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-3CDS	ENST00000508084	ENST00000544564	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000541571	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000535424	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000378799	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000538565	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000606369	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000329908	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000538850	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+
intron-intron	ENST00000508084	ENST00000378798	INPP4B	chr4	143687891	-	IST1	chr16	71924472	+

Top

FusionProtFeatures for INPP4B_IST1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INPP4B O15327	IST1 P53990
Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.	ESCRT-III-like protein involved in specific functions ofthe ESCRT machinery. Is required for efficient abscission duringcytokinesis, but not for HIV-1 budding. The involvement in the MVBpathway is not established. Involved in recruiting VPS4A and/orVPS4B to the midbody of dividing cells (PubMed:19129479,PubMed:19129480). During late anaphase, involved in nuclearenvelope reassembly and mitotic spindle disassembly together withthe ESCRT-III complex: IST1 acts by mediating the recruitment ofSPAST to the nuclear membrane, leading to microtubule severing(PubMed:26040712). Regulates early endosomal tubulation togetherwith the ESCRT-III complex by mediating the recruitment of SPAST(PubMed:23897888). {ECO:0000269\|PubMed:19129479,ECO:0000269\|PubMed:19129480, ECO:0000269\|PubMed:23897888,ECO:0000269\|PubMed:26040712}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for INPP4B_IST1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for INPP4B_IST1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for INPP4B_IST1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for INPP4B_IST1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 17498

FusionGeneSummary for INPP4B_IST1

FusionProtFeatures for INPP4B_IST1

FusionGeneSequence for INPP4B_IST1

FusionGenePPI for INPP4B_IST1

RelatedDrugs for INPP4B_IST1

RelatedDiseases for INPP4B_IST1