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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17495

FusionGeneSummary for INPP4B_ELF2

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP4B_ELF2
Fusion gene ID: 17495
HgeneTgene
Gene symbol

INPP4B

ELF2

Gene ID

8821

1998

Gene nameinositol polyphosphate-4-phosphatase type II BE74 like ETS transcription factor 2
Synonyms-EU32|NERF|NERF-1A|NERF-1B|NERF-1a,b|NERF-2
Cytomap

4q31.21

4q31.1

Type of geneprotein-codingprotein-coding
Descriptiontype II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDaETS-related transcription factor Elf-2E74-like factor 2 (ets domain transcription factor)ets family transcription factor ELF2Cnew Ets-related factor
Modification date2018052320180523
UniProtAcc

O15327

Q15723

Ensembl transtripts involved in fusion geneENST00000513000, ENST00000509777, 
ENST00000262992, ENST00000308502, 
ENST00000508116, ENST00000507861, 
ENST00000506217, ENST00000508084, 
ENST00000394235, ENST00000379549, 
ENST00000379550, ENST00000265495, 
ENST00000358635, ENST00000510408, 
ENST00000515489, 
Fusion gene scores* DoF score7 X 7 X 3=1472 X 2 X 2=8
# samples 82
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: INPP4B [Title/Abstract] AND ELF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELF2

GO:0006357

regulation of transcription by RNA polymerase II

8756667

TgeneELF2

GO:0045893

positive regulation of transcription, DNA-templated

8756667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1JA-01AINPP4Bchr4

143383816

-ELF2chr4

139949503

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000513000ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000513000ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000513000ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000513000ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000513000ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000513000ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-5UTRENST00000513000ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000509777ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-5UTRENST00000509777ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000262992ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-5UTRENST00000262992ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000308502ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-5UTRENST00000308502ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000508116ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-5UTRENST00000508116ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-intronENST00000507861ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
5UTR-5UTRENST00000507861ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000506217ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-5UTRENST00000506217ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000394235INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000379549INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000379550INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000265495INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000358635INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-intronENST00000508084ENST00000510408INPP4Bchr4

143383816

-ELF2chr4

139949503

-
intron-5UTRENST00000508084ENST00000515489INPP4Bchr4

143383816

-ELF2chr4

139949503

-

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FusionProtFeatures for INPP4B_ELF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP4B

O15327

ELF2

Q15723

Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Isoform 1 transcriptionally activates the LYN and BLKpromoters and acts synergistically with RUNX1 to transactivate theBLK promoter. Isoform 2 may function in repression of RUNX1-mediatedtransactivation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INPP4B_ELF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INPP4B_ELF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INPP4BELAVL1, PYCARD, ZNF131ELF2RUNX1, ZBTB32, BAP1, ELAVL1, APP, HSPBP1, PSME3, SPINT2, PRPS1, PSMC3, HIST1H2BG, HIST1H3A, DYNLT1, IKZF5, NFATC2IP, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INPP4B_ELF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INPP4B_ELF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELF2C3495559Juvenile arthritis1CTD_human