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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17486

FusionGeneSummary for INO80_CYSTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: INO80_CYSTM1
Fusion gene ID: 17486
HgeneTgene
Gene symbol

INO80

CYSTM1

Gene ID

54617

84418

Gene nameINO80 complex subunitcysteine rich transmembrane module containing 1
SynonymsINO80A|INOC1|hINO80C5orf32|ORF1-FL49
Cytomap

15q15.1

5q31.3

Type of geneprotein-codingprotein-coding
DescriptionDNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1cysteine-rich and transmembrane domain-containing protein 1UPF0467 protein C5orf32putative nuclear protein ORF1-FL49
Modification date2018052320180519
UniProtAcc

Q9ULG1

Q9H1C7

Ensembl transtripts involved in fusion geneENST00000361937, ENST00000401393, 
ENST00000561244, 
ENST00000261811, 
ENST00000509789, 
Fusion gene scores* DoF score6 X 6 X 5=1808 X 5 X 7=280
# samples 68
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INO80 [Title/Abstract] AND CYSTM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-WP-A9GB-01AINO80chr15

41337103

-CYSTM1chr5

139661081

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361937ENST00000261811INO80chr15

41337103

-CYSTM1chr5

139661081

+
5CDS-3UTRENST00000361937ENST00000509789INO80chr15

41337103

-CYSTM1chr5

139661081

+
5CDS-intronENST00000401393ENST00000261811INO80chr15

41337103

-CYSTM1chr5

139661081

+
5CDS-3UTRENST00000401393ENST00000509789INO80chr15

41337103

-CYSTM1chr5

139661081

+
intron-intronENST00000561244ENST00000261811INO80chr15

41337103

-CYSTM1chr5

139661081

+
intron-3UTRENST00000561244ENST00000509789INO80chr15

41337103

-CYSTM1chr5

139661081

+

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FusionProtFeatures for INO80_CYSTM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INO80

Q9ULG1

CYSTM1

Q9H1C7

ATPase component of the chromatin remodeling INO80complex which is involved in transcriptional regulation, DNAreplication and DNA repair (PubMed:16230350, PubMed:16298340,PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA(PubMed:16298340, PubMed:21303910). As part of the INO80 complex,remodels chromatin by shifting nucleosomes (PubMed:16230350,PubMed:21303910). Regulates transcription upon recruitment by YY1to YY1-activated genes, where it acts as an essential coactivator(PubMed:17721549). Involved in UV-damage excision DNA repair(PubMed:20855601). The contribution to DNA double-strand breakrepair appears to be largely indirect through transcriptionalregulation (PubMed:20687897). Involved in DNA replication(PubMed:20237820). Required for microtubule assembly duringmitosis thereby regulating chromosome segregation cycle(PubMed:20237820). {ECO:0000269|PubMed:16230350,ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897,ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INO80_CYSTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INO80_CYSTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INO80ACTN4, ACTR5, ACTB, RUVBL1, RUVBL2, INO80C, INO80B, YY1, ACTL6A, ACTR8, MCRS1, UCHL5, INO80D, INO80E, NFRKB, TFPT, TUBA1B, TUBA1A, DDX24, MBD3, POLR1A, DDB1, BAP1, HIST2H2AC, CA10, SMARCA5, MUS81, MLH1, POU5F1, BCL7C, BCL7ACYSTM1UQCR10, RAB11A, IER3IP1, NDUFB11, UQCRQ, TMX1, GNAI2, SLC16A1, GLP1R, MFSD4, SLC39A5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INO80_CYSTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INO80_CYSTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCYSTM1C0023893Liver Cirrhosis, Experimental1CTD_human