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Fusion gene ID: 17480 |
FusionGeneSummary for ING4_A2ML1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ING4_A2ML1 | Fusion gene ID: 17480 | Hgene | Tgene | Gene symbol | ING4 | A2ML1 | Gene ID | 51147 | 144568 |
| Gene name | inhibitor of growth family member 4 | alpha-2-macroglobulin like 1 | |
| Synonyms | my036|p29ING4 | CPAMD9|p170 | |
| Cytomap | 12p13.31 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inhibitor of growth protein 4brain my036 proteincandidate tumor suppressor p33 ING1 homolog | alpha-2-macroglobulin-like protein 1C3 and PZP-like, alpha-2-macroglobulin domain containing 9 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9UNL4 | A8K2U0 | |
| Ensembl transtripts involved in fusion gene | ENST00000341550, ENST00000396807, ENST00000446105, ENST00000486287, ENST00000444704, ENST00000423703, ENST00000412586, | ENST00000299698, ENST00000539547, ENST00000540049, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 3=36 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ING4 [Title/Abstract] AND A2ML1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ING4 | GO:0006260 | DNA replication | 16387653 |
| Hgene | ING4 | GO:0006473 | protein acetylation | 12750254 |
| Hgene | ING4 | GO:0006915 | apoptotic process | 15251430 |
| Hgene | ING4 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 16387653 |
| Hgene | ING4 | GO:0007050 | cell cycle arrest | 15251430 |
| Hgene | ING4 | GO:0008285 | negative regulation of cell proliferation | 12750254|15251430 |
| Hgene | ING4 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
| Hgene | ING4 | GO:0043966 | histone H3 acetylation | 16387653 |
| Hgene | ING4 | GO:0043981 | histone H4-K5 acetylation | 16387653 |
| Hgene | ING4 | GO:0043982 | histone H4-K8 acetylation | 16387653 |
| Hgene | ING4 | GO:0043983 | histone H4-K12 acetylation | 16387653 |
| Hgene | ING4 | GO:0043984 | histone H4-K16 acetylation | 16387653 |
| Hgene | ING4 | GO:0045892 | negative regulation of transcription, DNA-templated | 15029197 |
| Hgene | ING4 | GO:0045926 | negative regulation of growth | 12750254 |
| Tgene | A2ML1 | GO:0052548 | regulation of endopeptidase activity | 16298998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A3CC-06A | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000341550 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000341550 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000341550 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000396807 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000396807 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000396807 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000446105 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000446105 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000446105 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| intron-3CDS | ENST00000486287 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| intron-3CDS | ENST00000486287 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| intron-intron | ENST00000486287 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000444704 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000444704 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000444704 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000423703 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000423703 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000423703 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000412586 | ENST00000299698 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| In-frame | ENST00000412586 | ENST00000539547 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
| 5CDS-intron | ENST00000412586 | ENST00000540049 | ING4 | chr12 | 6772231 | - | A2ML1 | chr12 | 9027021 | + |
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FusionProtFeatures for ING4_A2ML1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ING4 | A2ML1 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000341550 | - | 1 | 8 | 25_118 | 12 | 249 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000396807 | - | 1 | 8 | 25_118 | 12 | 250 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000412586 | - | 1 | 8 | 25_118 | 12 | 247 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000423703 | - | 1 | 7 | 25_118 | 12 | 177 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000444704 | - | 1 | 7 | 25_118 | 12 | 226 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000446105 | - | 1 | 8 | 25_118 | 12 | 246 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000341550 | - | 1 | 8 | 127_148 | 12 | 249 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000396807 | - | 1 | 8 | 127_148 | 12 | 250 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000412586 | - | 1 | 8 | 127_148 | 12 | 247 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000423703 | - | 1 | 7 | 127_148 | 12 | 177 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000444704 | - | 1 | 7 | 127_148 | 12 | 226 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000446105 | - | 1 | 8 | 127_148 | 12 | 246 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000341550 | - | 1 | 8 | 196_245 | 12 | 249 | Zinc finger | PHD-type |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000396807 | - | 1 | 8 | 196_245 | 12 | 250 | Zinc finger | PHD-type |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000412586 | - | 1 | 8 | 196_245 | 12 | 247 | Zinc finger | PHD-type |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000423703 | - | 1 | 7 | 196_245 | 12 | 177 | Zinc finger | PHD-type |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000444704 | - | 1 | 7 | 196_245 | 12 | 226 | Zinc finger | PHD-type |
| Hgene | >ING4 | chr12:6772231 | chr12:9027021 | ENST00000446105 | - | 1 | 8 | 196_245 | 12 | 246 | Zinc finger | PHD-type |
| Tgene | A2ML1 | chr12:6772231 | chr12:9027021 | ENST00000299698 | + | 32 | 36 | 695_726 | 1407 | 1617 | Region | Bait region |
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FusionGeneSequence for ING4_A2ML1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_60aa >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_60aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_181nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_957nt ACAGTCACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATT AAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTAC CTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTAC TGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGA ATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCA GGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTA GAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTG AGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCC TGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCA CTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGA >In-frame_ING4_ENST00000341550_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_628nt ACAGTCACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATT AAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTAC CTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTAC TGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGA ATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCA GGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTA >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_949nt TTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACAC TCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGA TGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGT GGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCT GAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATA GGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGAT AAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGG AGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCG CAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCC TGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGA >In-frame_ING4_ENST00000396807_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_620nt TTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACAC TCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGA TGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGT GGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCT GAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATA GGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGAT >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_951nt ACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAAC ACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCA GATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGG GTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGT CTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCA TAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAG ATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCA GGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAAT CGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAG CCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGT >In-frame_ING4_ENST00000446105_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_622nt ACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAAC ACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCA GATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGG GTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGT CTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCA TAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAG >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_910nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA >In-frame_ING4_ENST00000444704_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_581nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_910nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA >In-frame_ING4_ENST00000423703_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_581nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000299698_chr12_9027021_+_910nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA >In-frame_ING4_ENST00000412586_chr12_6772231_-_A2ML1_ENST00000539547_chr12_9027021_+_581nt ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT |
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FusionGenePPI for ING4_A2ML1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ING4 | RELA, EP300, TP53, CDKN2A, EGLN1, JADE1, JADE2, JADE3, KAT7, MEAF6, HIST2H3C, PPFIA1, G3BP2, HIST3H3, UBE2D2, HOXB9, TLX3, ING4, HIST1H3A, PADI4, CDC34, MSX1, SUV39H1, GADD45A, NAV2, HNRNPD, MYC, MAPK8IP2, KMT2A, BRPF1, HIST1H2BN, NOLC1, RPP38, EBNA1BP2, POGZ, BRD1, H2AFJ, TRIM56, PCGF1, DPPA4, BCOR, EGFR, WEE1, TUBA1A | A2ML1 | WWOX, UGT1A10, L2HGDH, GMCL1, RASSF9, HNRNPA1, CEP152, FOXD4, FOXH1, TBC1D22B, PDE4DIP, NPPA, FTH1, FRMD1, PI4KA, FCRL5, GPATCH2L, ZFAND4, ZSCAN12, CDK15, DUSP21, THRA, ACAD9, TOX4, SLC39A11, CCNYL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ING4_A2ML1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ING4_A2ML1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | A2ML1 | C0029882 | Otitis Media | 1 | CTD_human |
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