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Fusion gene ID: 17479 |
FusionGeneSummary for ING2_ING2 |
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Fusion gene information | Fusion gene name: ING2_ING2 | Fusion gene ID: 17479 | Hgene | Tgene | Gene symbol | ING2 | ING2 | Gene ID | 54556 | 54556 |
Gene name | inhibitor of growth family member 3 | inhibitor of growth family member 3 | |
Synonyms | Eaf4|ING2|MEAF4|p47ING3 | Eaf4|ING2|MEAF4|p47ING3 | |
Cytomap | 7q31.31 | 7q31.31 | |
Type of gene | protein-coding | protein-coding | |
Description | inhibitor of growth protein 3 | inhibitor of growth protein 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9H160 | Q9H160 | |
Ensembl transtripts involved in fusion gene | ENST00000302327, ENST00000434682, | ENST00000302327, ENST00000434682, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ING2 [Title/Abstract] AND ING2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ING2 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
Hgene | ING2 | GO:0043967 | histone H4 acetylation | 14966270|16387653 |
Hgene | ING2 | GO:0043968 | histone H2A acetylation | 14966270|16387653 |
Tgene | ING2 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
Tgene | ING2 | GO:0043967 | histone H4 acetylation | 14966270|16387653 |
Tgene | ING2 | GO:0043968 | histone H2A acetylation | 14966270|16387653 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI745293 | ING2 | chr4 | 184431456 | + | ING2 | chr4 | 184431817 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000302327 | ENST00000302327 | ING2 | chr4 | 184431456 | + | ING2 | chr4 | 184431817 | - |
In-frame | ENST00000302327 | ENST00000434682 | ING2 | chr4 | 184431456 | + | ING2 | chr4 | 184431817 | - |
In-frame | ENST00000434682 | ENST00000302327 | ING2 | chr4 | 184431456 | + | ING2 | chr4 | 184431817 | - |
In-frame | ENST00000434682 | ENST00000434682 | ING2 | chr4 | 184431456 | + | ING2 | chr4 | 184431817 | - |
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FusionProtFeatures for ING2_ING2 |
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Hgene | Tgene |
ING2 | ING2 |
Seems to be involved in p53/TP53 activation andp53/TP53-dependent apoptotic pathways, probably by enhancingacetylation of p53/TP53. Component of a mSin3A-like corepressorcomplex, which is probably involved in deacetylation ofnucleosomal histones. ING2 activity seems to be modulated bybinding to phosphoinositides (PtdInsPs).{ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}. | Seems to be involved in p53/TP53 activation andp53/TP53-dependent apoptotic pathways, probably by enhancingacetylation of p53/TP53. Component of a mSin3A-like corepressorcomplex, which is probably involved in deacetylation ofnucleosomal histones. ING2 activity seems to be modulated bybinding to phosphoinositides (PtdInsPs).{ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ING2_ING2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ING2_ING2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ING2_ING2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ING2_ING2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |