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Fusion gene ID: 17478 |
FusionGeneSummary for ING2_IDH1 |
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Fusion gene information | Fusion gene name: ING2_IDH1 | Fusion gene ID: 17478 | Hgene | Tgene | Gene symbol | ING2 | IDH1 | Gene ID | 54556 | 3417 |
Gene name | inhibitor of growth family member 3 | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | |
Synonyms | Eaf4|ING2|MEAF4|p47ING3 | HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD | |
Cytomap | 7q31.31 | 2q34 | |
Type of gene | protein-coding | protein-coding | |
Description | inhibitor of growth protein 3 | isocitrate dehydrogenase [NADP] cytoplasmicNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26isocitrate dehydrog | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q9H160 | O75874 | |
Ensembl transtripts involved in fusion gene | ENST00000302327, ENST00000434682, | ENST00000345146, ENST00000446179, ENST00000415913, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ING2 [Title/Abstract] AND IDH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ING2 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
Hgene | ING2 | GO:0043967 | histone H4 acetylation | 14966270|16387653 |
Hgene | ING2 | GO:0043968 | histone H2A acetylation | 14966270|16387653 |
Tgene | IDH1 | GO:0006102 | isocitrate metabolic process | 10521434|19935646|20171178 |
Tgene | IDH1 | GO:0006103 | 2-oxoglutarate metabolic process | 19935646 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5516-01A | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000302327 | ENST00000345146 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
5CDS-intron | ENST00000302327 | ENST00000446179 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
5CDS-intron | ENST00000302327 | ENST00000415913 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
intron-intron | ENST00000434682 | ENST00000345146 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
intron-intron | ENST00000434682 | ENST00000446179 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
intron-intron | ENST00000434682 | ENST00000415913 | ING2 | chr4 | 184426520 | + | IDH1 | chr2 | 209120313 | - |
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FusionProtFeatures for ING2_IDH1 |
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Hgene | Tgene |
ING2 | IDH1 |
Seems to be involved in p53/TP53 activation andp53/TP53-dependent apoptotic pathways, probably by enhancingacetylation of p53/TP53. Component of a mSin3A-like corepressorcomplex, which is probably involved in deacetylation ofnucleosomal histones. ING2 activity seems to be modulated bybinding to phosphoinositides (PtdInsPs).{ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ING2_IDH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ING2_IDH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ING2 | SIN3A, HDAC1, HDAC2, SUDS3, RBBP7, RBBP4, ARID4A, ARID4B, SAP130, BRMS1L, SAP30, SMARCC2, SMARCC1, ACTL6A, SMARCB1, PCNA, EP300, TP53, SKIL, SMAD2, SIRT1, COPS2, SMURF1, APP, HIST3H3, WDR5, PRMT5, FOXK1, FOXK2, NANOG, GATAD1, FAM60A, SIN3B, CENPH, SAP30L, TARSL2, BRMS1, ZNF704, MXD3, BAHCC1, PCM1, AHNAK | IDH1 | ZHX1, ELAVL1, SLC2A4, CDK2, ASF1B, AK1, MDH2, AK2, PEX5, ADSS, GLRX3, HSPE1, ANXA6, C12orf10, CBX3, CHMP4A, DCK, EFHD2, FDPS, GOT1, NME1, OXCT1, RANBP1, SBDS, THOP1, UBE2H, NME1-NME2, PTMS, RBBP7, RCN1, SUGT1, TALDO1, MOV10, NXF1, CAB39, DAZAP1, FAM49B, HSD17B4, ARF4, ETHE1, IDH2, IDH3A, IDH3B, IDH3G, TKT, LTA4H, PCBP1, PHB2, NTRK1, IDH1, CDH1, AGGF1, DKK3, CRACR2B, FAM131A, FHL2, FIGNL1, LAX1, NUP62, PRDM14, TMOD4, UBL7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ING2_IDH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ING2_IDH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IDH1 | C0017638 | Glioma | 4 | CTD_human |
Tgene | IDH1 | C0014084 | Enchondromatosis | 2 | CTD_human;HPO;ORPHANET |
Tgene | IDH1 | C0936248 | Chondroma | 2 | CTD_human |
Tgene | IDH1 | C0018916 | Hemangioma | 1 | CTD_human |
Tgene | IDH1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | IDH1 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
Tgene | IDH1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | IDH1 | C0028945 | oligodendroglioma | 1 | CTD_human |
Tgene | IDH1 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Tgene | IDH1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Tgene | IDH1 | C2239176 | Liver carcinoma | 1 | CTD_human |