FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17478

FusionGeneSummary for ING2_IDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ING2_IDH1
Fusion gene ID: 17478
HgeneTgene
Gene symbol

ING2

IDH1

Gene ID

54556

3417

Gene nameinhibitor of growth family member 3isocitrate dehydrogenase (NADP(+)) 1, cytosolic
SynonymsEaf4|ING2|MEAF4|p47ING3HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD
Cytomap

7q31.31

2q34

Type of geneprotein-codingprotein-coding
Descriptioninhibitor of growth protein 3isocitrate dehydrogenase [NADP] cytoplasmicNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26isocitrate dehydrog
Modification date2018051920180527
UniProtAcc

Q9H160

O75874

Ensembl transtripts involved in fusion geneENST00000302327, ENST00000434682, 
ENST00000345146, ENST00000446179, 
ENST00000415913, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ING2 [Title/Abstract] AND IDH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneING2

GO:0043065

positive regulation of apoptotic process

16387653

HgeneING2

GO:0043967

histone H4 acetylation

14966270|16387653

HgeneING2

GO:0043968

histone H2A acetylation

14966270|16387653

TgeneIDH1

GO:0006102

isocitrate metabolic process

10521434|19935646|20171178

TgeneIDH1

GO:0006103

2-oxoglutarate metabolic process

19935646


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5516-01AING2chr4

184426520

+IDH1chr2

209120313

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302327ENST00000345146ING2chr4

184426520

+IDH1chr2

209120313

-
5CDS-intronENST00000302327ENST00000446179ING2chr4

184426520

+IDH1chr2

209120313

-
5CDS-intronENST00000302327ENST00000415913ING2chr4

184426520

+IDH1chr2

209120313

-
intron-intronENST00000434682ENST00000345146ING2chr4

184426520

+IDH1chr2

209120313

-
intron-intronENST00000434682ENST00000446179ING2chr4

184426520

+IDH1chr2

209120313

-
intron-intronENST00000434682ENST00000415913ING2chr4

184426520

+IDH1chr2

209120313

-

Top

FusionProtFeatures for ING2_IDH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ING2

Q9H160

IDH1

O75874

Seems to be involved in p53/TP53 activation andp53/TP53-dependent apoptotic pathways, probably by enhancingacetylation of p53/TP53. Component of a mSin3A-like corepressorcomplex, which is probably involved in deacetylation ofnucleosomal histones. ING2 activity seems to be modulated bybinding to phosphoinositides (PtdInsPs).{ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ING2_IDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ING2_IDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ING2SIN3A, HDAC1, HDAC2, SUDS3, RBBP7, RBBP4, ARID4A, ARID4B, SAP130, BRMS1L, SAP30, SMARCC2, SMARCC1, ACTL6A, SMARCB1, PCNA, EP300, TP53, SKIL, SMAD2, SIRT1, COPS2, SMURF1, APP, HIST3H3, WDR5, PRMT5, FOXK1, FOXK2, NANOG, GATAD1, FAM60A, SIN3B, CENPH, SAP30L, TARSL2, BRMS1, ZNF704, MXD3, BAHCC1, PCM1, AHNAKIDH1ZHX1, ELAVL1, SLC2A4, CDK2, ASF1B, AK1, MDH2, AK2, PEX5, ADSS, GLRX3, HSPE1, ANXA6, C12orf10, CBX3, CHMP4A, DCK, EFHD2, FDPS, GOT1, NME1, OXCT1, RANBP1, SBDS, THOP1, UBE2H, NME1-NME2, PTMS, RBBP7, RCN1, SUGT1, TALDO1, MOV10, NXF1, CAB39, DAZAP1, FAM49B, HSD17B4, ARF4, ETHE1, IDH2, IDH3A, IDH3B, IDH3G, TKT, LTA4H, PCBP1, PHB2, NTRK1, IDH1, CDH1, AGGF1, DKK3, CRACR2B, FAM131A, FHL2, FIGNL1, LAX1, NUP62, PRDM14, TMOD4, UBL7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ING2_IDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ING2_IDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDH1C0017638Glioma4CTD_human
TgeneIDH1C0014084Enchondromatosis2CTD_human;HPO;ORPHANET
TgeneIDH1C0936248Chondroma2CTD_human
TgeneIDH1C0018916Hemangioma1CTD_human
TgeneIDH1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneIDH1C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneIDH1C0027643Neoplasm Recurrence, Local1CTD_human
TgeneIDH1C0028945oligodendroglioma1CTD_human
TgeneIDH1C0206698Cholangiocarcinoma1CTD_human
TgeneIDH1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIDH1C2239176Liver carcinoma1CTD_human