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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17477

FusionGeneSummary for ING1_ING1

check button Fusion gene summary
Fusion gene informationFusion gene name: ING1_ING1
Fusion gene ID: 17477
HgeneTgene
Gene symbol

ING1

ING1

Gene ID

3621

3621

Gene nameinhibitor of growth family member 1inhibitor of growth family member 1
Synonymsp24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1ap24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptioninhibitor of growth protein 1growth inhibitor ING1growth inhibitory protein ING1tumor suppressor ING1inhibitor of growth protein 1growth inhibitor ING1growth inhibitory protein ING1tumor suppressor ING1
Modification date2018051920180519
UniProtAcc

Q9UK53

Q9UK53

Ensembl transtripts involved in fusion geneENST00000338450, ENST00000333219, 
ENST00000375775, ENST00000375774, 
ENST00000464141, 		ENST00000338450, 
ENST00000333219, ENST00000375775, 
ENST00000375774, ENST00000464141, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: ING1 [Title/Abstract] AND ING1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ306241ING1chr13

111372146

+ING1chr13

111372089

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338450ENST00000338450ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000338450ENST00000333219ING1chr13

111372146

+ING1chr13

111372089

-
In-frameENST00000338450ENST00000375775ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000338450ENST00000375774ING1chr13

111372146

+ING1chr13

111372089

-
5CDS-intronENST00000338450ENST00000464141ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000333219ENST00000338450ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000333219ENST00000333219ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000333219ENST00000375775ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000333219ENST00000375774ING1chr13

111372146

+ING1chr13

111372089

-
5CDS-intronENST00000333219ENST00000464141ING1chr13

111372146

+ING1chr13

111372089

-
In-frameENST00000375775ENST00000338450ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375775ENST00000333219ING1chr13

111372146

+ING1chr13

111372089

-
In-frameENST00000375775ENST00000375775ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375775ENST00000375774ING1chr13

111372146

+ING1chr13

111372089

-
5CDS-intronENST00000375775ENST00000464141ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375774ENST00000338450ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375774ENST00000333219ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375774ENST00000375775ING1chr13

111372146

+ING1chr13

111372089

-
Frame-shiftENST00000375774ENST00000375774ING1chr13

111372146

+ING1chr13

111372089

-
5CDS-intronENST00000375774ENST00000464141ING1chr13

111372146

+ING1chr13

111372089

-
intron-3CDSENST00000464141ENST00000338450ING1chr13

111372146

+ING1chr13

111372089

-
intron-3CDSENST00000464141ENST00000333219ING1chr13

111372146

+ING1chr13

111372089

-
intron-3CDSENST00000464141ENST00000375775ING1chr13

111372146

+ING1chr13

111372089

-
intron-3CDSENST00000464141ENST00000375774ING1chr13

111372146

+ING1chr13

111372089

-
intron-intronENST00000464141ENST00000464141ING1chr13

111372146

+ING1chr13

111372089

-

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FusionProtFeatures for ING1_ING1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ING1

Q9UK53

ING1

Q9UK53


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ING1_ING1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ING1_ING1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ING1_ING1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ING1_ING1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneING1C0011616Contact Dermatitis1CTD_human
HgeneING1C0038356Stomach Neoplasms1CTD_human
HgeneING1C1168401Squamous cell carcinoma of the head and neck1CTD_human;ORPHANET;UNIPROT
TgeneING1C0011616Contact Dermatitis1CTD_human
TgeneING1C0038356Stomach Neoplasms1CTD_human
TgeneING1C1168401Squamous cell carcinoma of the head and neck1CTD_human;ORPHANET;UNIPROT