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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17467

FusionGeneSummary for INADL_PDE4B

check button Fusion gene summary
Fusion gene informationFusion gene name: INADL_PDE4B
Fusion gene ID: 17467
HgeneTgene
Gene symbol

INADL

PDE4B

Gene ID

10207

5142

Gene namePATJ, crumbs cell polarity complex componentphosphodiesterase 4B
SynonymsCipp|INADL|InaD-like|hINADLDPDE4|PDEIVB
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
DescriptioninaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctionscAMP-specific 3',5'-cyclic phosphodiesterase 4Bdunce-like phosphodiesterase E4phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
Modification date2018052220180519
UniProtAcc

Q07343

Ensembl transtripts involved in fusion geneENST00000316485, ENST00000371158, 
ENST00000543708, ENST00000545929, 
ENST00000472512, 		ENST00000329654, 
ENST00000371049, ENST00000423207, 
ENST00000371048, ENST00000371045, 
ENST00000480109, 
Fusion gene scores* DoF score8 X 6 X 7=3367 X 7 X 4=196
# samples 98
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INADL [Title/Abstract] AND PDE4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDE4B

GO:0006198

cAMP catabolic process

17404263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7077-01AINADLchr1

62393501

+PDE4Bchr1

66713143

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000316485ENST00000329654INADLchr1

62393501

+PDE4Bchr1

66713143

+
Frame-shiftENST00000316485ENST00000371049INADLchr1

62393501

+PDE4Bchr1

66713143

+
Frame-shiftENST00000316485ENST00000423207INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000316485ENST00000371048INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000316485ENST00000371045INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000316485ENST00000480109INADLchr1

62393501

+PDE4Bchr1

66713143

+
Frame-shiftENST00000371158ENST00000329654INADLchr1

62393501

+PDE4Bchr1

66713143

+
Frame-shiftENST00000371158ENST00000371049INADLchr1

62393501

+PDE4Bchr1

66713143

+
Frame-shiftENST00000371158ENST00000423207INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000371158ENST00000371048INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000371158ENST00000371045INADLchr1

62393501

+PDE4Bchr1

66713143

+
5CDS-intronENST00000371158ENST00000480109INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000543708ENST00000329654INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000543708ENST00000371049INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000543708ENST00000423207INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000543708ENST00000371048INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000543708ENST00000371045INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000543708ENST00000480109INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000545929ENST00000329654INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000545929ENST00000371049INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000545929ENST00000423207INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000545929ENST00000371048INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000545929ENST00000371045INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000545929ENST00000480109INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000472512ENST00000329654INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000472512ENST00000371049INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-3CDSENST00000472512ENST00000423207INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000472512ENST00000371048INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000472512ENST00000371045INADLchr1

62393501

+PDE4Bchr1

66713143

+
intron-intronENST00000472512ENST00000480109INADLchr1

62393501

+PDE4Bchr1

66713143

+

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FusionProtFeatures for INADL_PDE4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INADL

PDE4B

Q07343

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes. May beinvolved in mediating central nervous system effects oftherapeutic agents ranging from antidepressants to antiasthmaticand anti-inflammatory agents. {ECO:0000269|PubMed:10846163,ECO:0000269|PubMed:15003452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for INADL_PDE4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INADL_PDE4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INADLTJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1PDE4BDISC1, PAFAH1B1, APOA1, ALB, MAGEA11, RCBTB2, MOV10, NXF1, NTRK1, XPO1, PDE4D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INADL_PDE4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDE4BQ07343DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
TgenePDE4BQ07343DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
TgenePDE4BQ07343DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
TgenePDE4BQ07343DB01427AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
TgenePDE4BQ07343DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
TgenePDE4BQ07343DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
TgenePDE4BQ07343DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
TgenePDE4BQ07343DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
TgenePDE4BQ07343DB01412TheobrominecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
TgenePDE4BQ07343DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
TgenePDE4BQ07343DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational

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RelatedDiseases for INADL_PDE4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDE4BC0011570Mental Depression5PSYGENET
TgenePDE4BC0011581Depressive disorder5PSYGENET
TgenePDE4BC0005586Bipolar Disorder4CTD_human;PSYGENET
TgenePDE4BC0036341Schizophrenia2CTD_human
TgenePDE4BC0001973Alcoholic Intoxication, Chronic1CTD_human
TgenePDE4BC0004096Asthma1CTD_human
TgenePDE4BC0004352Autistic Disorder1CTD_human
TgenePDE4BC0023467Leukemia, Myelocytic, Acute1CTD_human
TgenePDE4BC0037274Dermatologic disorders1CTD_human
TgenePDE4BC0151744Myocardial Ischemia1CTD_human
TgenePDE4BC0236733Amphetamine-Related Disorders1CTD_human
TgenePDE4BC0311375Arsenic Poisoning1CTD_human