	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 17466

FusionGeneSummary for INADL_NFIA

Fusion gene summary

Fusion gene information	Fusion gene name: INADL_NFIA
	Fusion gene ID: 17466
		Hgene	Tgene
	Gene symbol	INADL	NFIA
	Gene ID	10207	4774
	Gene name	PATJ, crumbs cell polarity complex component	nuclear factor I A
	Synonyms	Cipp\|INADL\|InaD-like\|hINADL	BRMUTD\|CTF\|NF-I/A\|NF1-A\|NFI-A\|NFI-L
	Cytomap	1p31.3	1p31.3
	Type of gene	protein-coding	protein-coding
	Description	inaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctions	nuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding protein
	Modification date	20180522	20180523
	UniProtAcc		Q12857
	Ensembl transtripts involved in fusion gene	ENST00000316485, ENST00000371158, ENST00000543708, ENST00000545929, ENST00000472512,	ENST00000371191, ENST00000407417, ENST00000479364, ENST00000371189, ENST00000403491, ENST00000371187, ENST00000485903, ENST00000371185, ENST00000371184, ENST00000357977,
Fusion gene scores	* DoF score	8 X 6 X 7=336	11 X 13 X 6=858
	# samples	9	15
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: INADL [Title/Abstract] AND NFIA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NFIA	GO:0045944	positive regulation of transcription by RNA polymerase II	17010934

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	OV	TCGA-09-1667-01C	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
TCGA	RV	UCS	TCGA-NA-A4R1-01A	INADL	chr1	62232145	+	NFIA	chr1	61920975	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000316485	ENST00000371191	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000316485	ENST00000407417	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000479364	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371189	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000403491	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371187	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000485903	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371185	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371184	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000357977	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000371158	ENST00000371191	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000371158	ENST00000407417	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000479364	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371189	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000403491	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371187	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000485903	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371185	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371184	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000357977	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000543708	ENST00000371191	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000543708	ENST00000407417	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000479364	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371189	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000403491	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371187	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000485903	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371185	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371184	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000357977	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000545929	ENST00000371191	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000545929	ENST00000407417	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000479364	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371189	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000403491	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371187	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000485903	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371185	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371184	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000357977	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000472512	ENST00000371191	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000472512	ENST00000407417	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000479364	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371189	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000403491	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371187	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000485903	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371185	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371184	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000357977	INADL	chr1	62241006	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000316485	ENST00000371191	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000316485	ENST00000407417	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000479364	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371189	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000403491	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371187	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000485903	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371185	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000371184	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000316485	ENST00000357977	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000371158	ENST00000371191	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
Frame-shift	ENST00000371158	ENST00000407417	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000479364	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371189	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000403491	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371187	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000485903	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371185	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000371184	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
5CDS-intron	ENST00000371158	ENST00000357977	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000543708	ENST00000371191	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000543708	ENST00000407417	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000479364	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371189	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000403491	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371187	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000485903	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371185	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000371184	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000543708	ENST00000357977	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000545929	ENST00000371191	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000545929	ENST00000407417	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000479364	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371189	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000403491	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371187	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000485903	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371185	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000371184	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000545929	ENST00000357977	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000472512	ENST00000371191	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-3CDS	ENST00000472512	ENST00000407417	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000479364	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371189	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000403491	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371187	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000485903	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371185	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000371184	INADL	chr1	62232145	+	NFIA	chr1	61920975	+
intron-intron	ENST00000472512	ENST00000357977	INADL	chr1	62232145	+	NFIA	chr1	61920975	+

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FusionProtFeatures for INADL_NFIA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INADL	NFIA Q12857
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and inthe origin of replication of adenovirus type 2. These proteins areindividually capable of activating transcription and replication.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for INADL_NFIA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for INADL_NFIA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
INADL	TJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1	NFIA	ELAVL1, TFAP4, SAP18, PCDHA2, NOP2, TRA2A, HNRNPU, TPBG, SRSF7, NOP56, RRS1, RPS13, SON, SRSF10, FTSJ3, RRP7A, UTP14A, ZNF326, RPS6, DDX21, RPS24, SURF4, DHX9, TRIM55, VTN, LUC7L3, RBM25, HP1BP3, ACIN1, ADNP, SRSF3, TRA2B, RPS11, RPL37A, SMAD4, SMAD2, SMAD3, XPO1, CREB1, RBPJ, FOXC2, NFIB, UBC

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for INADL_NFIA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for INADL_NFIA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 17466

FusionGeneSummary for INADL_NFIA

FusionProtFeatures for INADL_NFIA

FusionGeneSequence for INADL_NFIA

FusionGenePPI for INADL_NFIA

RelatedDrugs for INADL_NFIA

RelatedDiseases for INADL_NFIA