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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 17465

FusionGeneSummary for INADL_MAP2K5

check button Fusion gene summary
Fusion gene informationFusion gene name: INADL_MAP2K5
Fusion gene ID: 17465
HgeneTgene
Gene symbol

INADL

MAP2K5

Gene ID

10207

5607

Gene namePATJ, crumbs cell polarity complex componentmitogen-activated protein kinase kinase 5
SynonymsCipp|INADL|InaD-like|hINADLHsT17454|MAPKK5|MEK5|PRKMK5
Cytomap

1p31.3

15q23

Type of geneprotein-codingprotein-coding
DescriptioninaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctionsdual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
Modification date2018052220180523
UniProtAcc

Q13163

Ensembl transtripts involved in fusion geneENST00000316485, ENST00000371158, 
ENST00000543708, ENST00000545929, 
ENST00000472512, 		ENST00000178640, 
ENST00000560591, ENST00000395476, 
ENST00000354498, ENST00000340972, 
Fusion gene scores* DoF score8 X 6 X 7=3368 X 7 X 9=504
# samples 913
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INADL [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-DC-6683-01AINADLchr1

62274202

+MAP2K5chr15

68040569

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000316485ENST00000178640INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000316485ENST00000560591INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000316485ENST00000395476INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000316485ENST00000354498INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000316485ENST00000340972INADLchr1

62274202

+MAP2K5chr15

68040569

+
In-frameENST00000371158ENST00000178640INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000371158ENST00000560591INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000371158ENST00000395476INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000371158ENST00000354498INADLchr1

62274202

+MAP2K5chr15

68040569

+
5CDS-intronENST00000371158ENST00000340972INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-3CDSENST00000543708ENST00000178640INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000543708ENST00000560591INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000543708ENST00000395476INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000543708ENST00000354498INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000543708ENST00000340972INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-3CDSENST00000545929ENST00000178640INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000545929ENST00000560591INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000545929ENST00000395476INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000545929ENST00000354498INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000545929ENST00000340972INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-3CDSENST00000472512ENST00000178640INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000472512ENST00000560591INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000472512ENST00000395476INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000472512ENST00000354498INADLchr1

62274202

+MAP2K5chr15

68040569

+
intron-intronENST00000472512ENST00000340972INADLchr1

62274202

+MAP2K5chr15

68040569

+

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FusionProtFeatures for INADL_MAP2K5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INADL

MAP2K5

Q13163

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of thispathway appears to play a critical role in protecting cells fromstress-induced apoptosis, neuronal survival and cardiacdevelopment and angiogenesis. {ECO:0000269|PubMed:7759517,ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+1436134_2215611583DomainPDZ 1
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361_655611583DomainL27
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+1436248_3285611583DomainPDZ 2
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+1436365_4535611583DomainPDZ 3
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+1443134_2215611802DomainPDZ 1
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431_655611802DomainL27
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+1443248_3285611802DomainPDZ 2
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+1443365_4535611802DomainPDZ 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361068_11605611583DomainPDZ 6
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361239_13225611583DomainPDZ 7
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361437_15205611583DomainPDZ 8
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361533_16155611583DomainPDZ 9
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+14361676_17625611583DomainPDZ 10
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+1436553_6395611583DomainPDZ 4
HgeneINADLchr1:62274202chr15:68040569ENST00000316485+1436686_7725611583DomainPDZ 5
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431068_11605611802DomainPDZ 6
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431239_13225611802DomainPDZ 7
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431437_15205611802DomainPDZ 8
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431533_16155611802DomainPDZ 9
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+14431676_17625611802DomainPDZ 10
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+1443553_6395611802DomainPDZ 4
HgeneINADLchr1:62274202chr15:68040569ENST00000371158+1443686_7725611802DomainPDZ 5
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+1622166_409358449DomainProtein kinase
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+162218_109358449DomainPB1
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+1622166_409322413DomainProtein kinase
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+162218_109322413DomainPB1
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+1521166_409348439DomainProtein kinase
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+152118_109348439DomainPB1
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+1622172_180358449Nucleotide bindingATP
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+1622172_180322413Nucleotide bindingATP
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+1521172_180348439Nucleotide bindingATP


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FusionGeneSequence for INADL_MAP2K5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_INADL_ENST00000316485_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_652aa
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNA

>In-frame_INADL_ENST00000371158_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_652aa
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_INADL_ENST00000316485_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_1956nt
ATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAATTGCAGGAGAAGGGTGACACGTCG
CAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACACTTCAGCAGTCCATCAAGCAACTG
AAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTGTTAGTGTTCACAGATGGTTCCATC
ACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCGAAGTTGGGAAATGAAGACTTTAAC
TCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACTGGAGGCCTTGGATTCAGTGTGGTG
GCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTAGCAGACAGGGATCAAAGATTAAAG
GAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCAATTGCATTATTACAACAAACCACT
GGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTAAATGATACAACTCTGCCTGAAACA
GTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATAGTTGGAGGAAAAACAAGTGGCGTG
GTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCACATCTTGAAGATTGGTGGCACAAAC
GTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATGCTCGTTGCTAGAGATCCAGCTGGT
GACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAGGGCCCTGGTTCTGACAGTTCTCTT
TTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGCTATGTTGGAACATCTCATACAGGG
GAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATTCAAGTGAATGACAAAATAGTTGCT
GTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGGCAGGTGGTACACCTAACCCTAGTT
CGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAACCACTGAAACCACCAGCTCTCTTT
CTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATTGATACTTTAAAAAATGACAACATA
CAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAAAACCTGTTGGGTCCTGATTATGAA
GTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGATTCAGAAAAACCAGGGATCTTTAATG
CCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACT
CAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAATGCC

>In-frame_INADL_ENST00000371158_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_1956nt
ATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAATTGCAGGAGAAGGGTGACACGTCG
CAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACACTTCAGCAGTCCATCAAGCAACTG
AAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTGTTAGTGTTCACAGATGGTTCCATC
ACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCGAAGTTGGGAAATGAAGACTTTAAC
TCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACTGGAGGCCTTGGATTCAGTGTGGTG
GCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTAGCAGACAGGGATCAAAGATTAAAG
GAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCAATTGCATTATTACAACAAACCACT
GGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTAAATGATACAACTCTGCCTGAAACA
GTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATAGTTGGAGGAAAAACAAGTGGCGTG
GTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCACATCTTGAAGATTGGTGGCACAAAC
GTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATGCTCGTTGCTAGAGATCCAGCTGGT
GACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAGGGCCCTGGTTCTGACAGTTCTCTT
TTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGCTATGTTGGAACATCTCATACAGGG
GAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATTCAAGTGAATGACAAAATAGTTGCT
GTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGGCAGGTGGTACACCTAACCCTAGTT
CGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAACCACTGAAACCACCAGCTCTCTTT
CTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATTGATACTTTAAAAAATGACAACATA
CAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAAAACCTGTTGGGTCCTGATTATGAA
GTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGATTCAGAAAAACCAGGGATCTTTAATG
CCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACT
CAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAATGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_INADL_ENST00000316485_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_2443nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGATT
CAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCG
GAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATC
GTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGA
GGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAG
AGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGAGCCCCATGTGTGGCCCACCCCA
CCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTC
CCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGGAATAAAAGTATTAATGCTTTGT

>In-frame_INADL_ENST00000371158_chr1_62274202_+_MAP2K5_ENST00000178640_chr15_68040569_+_2443nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGATT
CAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCG
GAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATC
GTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGA
GGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAG
AGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGAGCCCCATGTGTGGCCCACCCCA
CCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTC
CCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGGAATAAAAGTATTAATGCTTTGT


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FusionGenePPI for INADL_MAP2K5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
INADLTJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1MAP2K5MAP3K3, MAP3K2, PRKCZ, MAPK7, MAP2K5, YWHAZ, CDC42BPB, ENO1, SQSTM1, ASRGL1, STAMBP, PRKCI, PARD6A, HSP90AA1, GCH1, XRCC6, ESRRA, RPL28, NXF1, LNX2, TRAF7, C10orf88, CDC37


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+162264_68358449MAP3K2/MAP3K3
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+162264_68322413MAP3K2/MAP3K3
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+152164_68348439MAP3K2/MAP3K3
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+1622117_131358449MAPK7
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000178640+162218_25358449MAPK7
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+1622117_131322413MAPK7
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000354498+162218_25322413MAPK7
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+1521117_131348439MAPK7
TgeneMAP2K5chr1:62274202chr15:68040569ENST00000395476+152118_25348439MAPK7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for INADL_MAP2K5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for INADL_MAP2K5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAP2K5C0005910Body Weight1CTD_human
TgeneMAP2K5C0011581Depressive disorder1PSYGENET
TgeneMAP2K5C0236733Amphetamine-Related Disorders1CTD_human