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Fusion gene ID: 17459 |
FusionGeneSummary for IMPDH1_GRM8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IMPDH1_GRM8 | Fusion gene ID: 17459 | Hgene | Tgene | Gene symbol | IMPDH1 | GRM8 | Gene ID | 3614 | 2918 |
| Gene name | inosine monophosphate dehydrogenase 1 | glutamate metabotropic receptor 8 | |
| Synonyms | IMPD|IMPD1|IMPDH-I|LCA11|RP10|sWSS2608 | GLUR8|GPRC1H|MGLUR8|mGlu8 | |
| Cytomap | 7q32.1 | 7q31.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inosine-5'-monophosphate dehydrogenase 1IMP (inosine 5'-monophosphate) dehydrogenase 1IMP (inosine monophosphate) dehydrogenase 1IMPD 1IMPDH 1 | metabotropic glutamate receptor 8glutamate receptor, metabotropic 8 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P20839 | O00222 | |
| Ensembl transtripts involved in fusion gene | ENST00000419067, ENST00000338791, ENST00000496200, ENST00000354269, ENST00000378717, ENST00000343214, ENST00000348127, ENST00000470772, ENST00000480861, | ENST00000444921, ENST00000339582, ENST00000358373, ENST00000405249, ENST00000480995, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 6=294 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IMPDH1 [Title/Abstract] AND GRM8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRM8 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 11166323 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-ZN-A9VO-01A | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000419067 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000419067 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000419067 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000419067 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000419067 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000338791 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000338791 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000338791 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000338791 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000338791 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000496200 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000496200 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000496200 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000496200 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000496200 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354269 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354269 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354269 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354269 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000354269 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000378717 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000378717 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000378717 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000378717 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000378717 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| In-frame | ENST00000343214 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| In-frame | ENST00000343214 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| In-frame | ENST00000343214 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| In-frame | ENST00000343214 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000343214 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000348127 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000348127 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000348127 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000348127 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000348127 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000470772 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000470772 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000470772 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000470772 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000470772 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000480861 | ENST00000444921 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000480861 | ENST00000339582 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000480861 | ENST00000358373 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000480861 | ENST00000405249 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000480861 | ENST00000480995 | IMPDH1 | chr7 | 128043760 | - | GRM8 | chr7 | 126544737 | - |
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FusionProtFeatures for IMPDH1_GRM8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IMPDH1 | GRM8 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IMPDH1_GRM8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000444921_chr7_126544737_-_715aa MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVVVFALLSHRKSHVNQDLENLKKLSNACXKHLMLEQXLCLPM RMTSGGYWKQQKNXTKVGIFSGLAQIVGDPKXHLSISKRRLQKGLXQFCPNEHQLMDLIDTLEAELLPIIEEMCGLQNSGRRILAASXDH MGKGTVIXRNAQGWSELLGIHLMNRKERSNLXLMLYIPWLTPCTICTKISALDTLAFVHEXVPLMGKSYLVIFGLXILMAVLALLSLLMK TEMLLDVMISSSIKXPTKAQSTKSSATGPISFIXKWKTCSGLIENILTRRLSAACRVSQGRGRKRXKGSLAAGTVNAVKVTTTRWMSCPV NFALWIRDPTXTAQAASLSPSSNWSGILPGLWCLCLLQYWESSPPPLXSXPLSAIMTHLSXGLQDANLVTCSXRGFFSVIQSRFXXLQHQ IQSYAPSDGSSXDLACVSAMQPFXPKQTVSTEYLSRGRNLSQRPSSLVQHLSWXSPSASSPSSSLECLSGLLWIPPTSSLTMESSGHXIQ RRPGECSSVTFLISHSFVHLDTVSSXWSLVLFMPLKREVSQRLSMKPNLLDLPCIPPASFGXLSSPSFLVQPSQQKRCTSRQQHLLSPXV >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000339582_chr7_126544737_-_715aa MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVVVFALLSHRKSHVNQDLENLKKLSNACXKHLMLEQXLCLPM RMTSGGYWKQQKNXTKVGIFSGLAQIVGDPKXHLSISKRRLQKGLXQFCPNEHQLMDLIDTLEAELLPIIEEMCGLQNSGRRILAASXDH MGKGTVIXRNAQGWSELLGIHLMNRKERSNLXLMLYIPWLTPCTICTKISALDTLAFVHEXVPLMGKSYLVIFGLXILMAVLALLSLLMK TEMLLDVMISSSIKXPTKAQSTKSSATGPISFIXKWKTCSGLIENILTRRLSAACRVSQGRGRKRXKGSLAAGTVNAVKVTTTRWMSCPV NFALWIRDPTXTAQAASLSPSSNWSGILPGLWCLCLLQYWESSPPPLXSXPLSAIMTHLSXGLQDANLVTCSXRGFFSVIQSRFXXLQHQ IQSYAPSDGSSXDLACVSAMQPFXPKQTVSTEYLSRGRNLSQRPSSLVQHLSWXSPSASSPSSSLECLSGLLWIPPTSSLTMESSGHXIQ RRPGECSSVTFLISHSFVHLDTVSSXWSLVLFMPLKREVSQRLSMKPNLLDLPCIPPASFGXLSSPSFLVQPSQQKRCTSRQQHLLSPXV >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000358373_chr7_126544737_-_715aa MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVVVFALLSHRKSHVNQDLENLKKLSNACXKHLMLEQXLCLPM RMTSGGYWKQQKNXTKVGIFSGLAQIVGDPKXHLSISKRRLQKGLXQFCPNEHQLMDLIDTLEAELLPIIEEMCGLQNSGRRILAASXDH MGKGTVIXRNAQGWSELLGIHLMNRKERSNLXLMLYIPWLTPCTICTKISALDTLAFVHEXVPLMGKSYLVIFGLXILMAVLALLSLLMK TEMLLDVMISSSIKXPTKAQSTKSSATGPISFIXKWKTCSGLIENILTRRLSAACRVSQGRGRKRXKGSLAAGTVNAVKVTTTRWMSCPV NFALWIRDPTXTAQAASLSPSSNWSGILPGLWCLCLLQYWESSPPPLXSXPLSAIMTHLSXGLQDANLVTCSXRGFFSVIQSRFXXLQHQ IQSYAPSDGSSXDLACVSAMQPFXPKQTVSTEYLSRGRNLSQRPSSLVQHLSWXSPSASSPSSSLECLSGLLWIPPTSSLTMESSGHXIQ RRPGECSSVTFLISHSFVHLDTVSSXWSLVLFMPLKREVSQRLSMKPNLLDLPCIPPASFGXLSSPSFLVQPSQQKRCTSRQQHLLSPXV >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000405249_chr7_126544737_-_308aa MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVVVFALLSHRKSHVNQDLENLKKLSNACXKHLMLEQXLCLPM RMTSGGYWKQQKNXTKVGIFSGLAQIVGDPKXHLSISKRRLQKGLXQFCPNEHQLMDLIDTLEAELLPIIEEMCGLQNSGRRILAASXDH MGKGTVIXRNAQGWSELLGIHLMNRKERSNLXLMLYIPWLTPCTICTKISALDTLAFVHEXVPLMGKSYLVIFGLXILMVAEEGSRCLYP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000444921_chr7_126544737_-_2147nt ATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTC ACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCC CACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAGAAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATG AGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTGGGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCA AAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAATTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGAT ACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAGAATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCAC ATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTGCTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAAT TTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACAAAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAA TGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATTTTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAA ACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACAAAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATC AGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTCACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGG AGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCTGTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTG AACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGCTTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGG CTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTGTGATCGTGACCTTTGTCCGCTATAATGACACACCTATCG TGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTCTCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAG ATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTTTCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCC ACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTAGTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCT CCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACATCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAG AGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTTGTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTA CTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCAAACCTATTGGATTTACCATGTATACCACCTGCATCATTT GGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGATGTACATCCAGACAACAACACTTACTGTCTCCATGAGTT TAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTATAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGA GGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCCAAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTG >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000339582_chr7_126544737_-_2147nt ATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTC ACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCC CACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAGAAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATG AGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTGGGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCA AAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAATTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGAT ACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAGAATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCAC ATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTGCTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAAT TTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACAAAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAA TGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATTTTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAA ACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACAAAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATC AGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTCACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGG AGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCTGTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTG AACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGCTTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGG CTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTGTGATCGTGACCTTTGTCCGCTATAATGACACACCTATCG TGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTCTCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAG ATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTTTCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCC ACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTAGTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCT CCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACATCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAG AGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTTGTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTA CTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCAAACCTATTGGATTTACCATGTATACCACCTGCATCATTT GGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGATGTACATCCAGACAACAACACTTACTGTCTCCATGAGTT TAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTATAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGA GGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCCAAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTG >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000358373_chr7_126544737_-_2147nt ATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTC ACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCC CACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAGAAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATG AGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTGGGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCA AAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAATTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGAT ACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAGAATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCAC ATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTGCTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAAT TTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACAAAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAA TGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATTTTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAA ACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACAAAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATC AGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTCACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGG AGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCTGTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTG AACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGCTTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGG CTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTGTGATCGTGACCTTTGTCCGCTATAATGACACACCTATCG TGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTCTCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAG ATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTTTCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCC ACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTAGTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCT CCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACATCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAG AGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTTGTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTA CTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCAAACCTATTGGATTTACCATGTATACCACCTGCATCATTT GGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGATGTACATCCAGACAACAACACTTACTGTCTCCATGAGTT TAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTATAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGA GGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCCAAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTG >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000405249_chr7_126544737_-_926nt ATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTC ACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCC CACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAGAAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATG AGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTGGGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCA AAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAATTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGAT ACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAGAATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCAC ATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTGCTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAAT TTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACAAAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAA TGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATTTTAATGGTTGCCGAAGAGGGATCCAGATGTCTCTACCCT GGCCAACTCTTTTTACTCCTTCATTTTCCAGTAGTTGGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000444921_chr7_126544737_-_2887nt GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACACTTCCTCTACCAAGACAACATATA TCAGTTACAGCAATCATTCAATCTGAAACAGGGAAATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCG CAAAAATTCACTCCTGGAGATCTCCGTAGACTACAATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAA AGTATCAATAAACGGGGAGTGAAGAAACCCGTTTTATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTA AAACAAATCACAAAAGGAAAACTAATGTTAGCTCGTGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCT GTGATTGTGAGAACTCCCGTTCCTGTCCCACATTGTTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAG CCCTGGGTTGTGCTAAAAATAAATGCAATGATTGATGCATGCAATTTTTTATACAAATAATTTATTTCTAATAATAAAGGAATGTTTTGC >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000339582_chr7_126544737_-_2887nt GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACACTTCCTCTACCAAGACAACATATA TCAGTTACAGCAATCATTCAATCTGAAACAGGGAAATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCG CAAAAATTCACTCCTGGAGATCTCCGTAGACTACAATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAA AGTATCAATAAACGGGGAGTGAAGAAACCCGTTTTATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTA AAACAAATCACAAAAGGAAAACTAATGTTAGCTCGTGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCT GTGATTGTGAGAACTCCCGTTCCTGTCCCACATTGTTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAG CCCTGGGTTGTGCTAAAAATAAATGCAATGATTGATGCATGCAATTTTTTATACAAATAATTTATTTCTAATAATAAAGGAATGTTTTGC >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000358373_chr7_126544737_-_2925nt GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACAGTAAGTCATCTGTAGAGTTTCCGA TGGTCAAGAGCGGGAGCACTTCCTAATAGATCTTCCTCTACCAAGACAACATATATCAGTTACAGCAATCATTCAATCTGAAACAGGGAA ATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCGCAAAAATTCACTCCTGGAGATCTCCGTAGACTACA ATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAAAGTATCAATAAACGGGGAGTGAAGAAACCCGTTTT ATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTAAAACAAATCACAAAAGGAAAACTAATGTTAGCTCG TGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCTGTGATTGTGAGAACTCCCGTTCCTGTCCCACATTG TTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAGCCCTGGGTTGTGCTAAAAATAAATGCAATGATTGA >In-frame_IMPDH1_ENST00000343214_chr7_128043760_-_GRM8_ENST00000405249_chr7_126544737_-_1145nt GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT TTAATGGTTGCCGAAGAGGGATCCAGATGTCTCTACCCTGGCCAACTCTTTTTACTCCTTCATTTTCCAGTAGTTGGGCAGTGCTGGCAC |
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FusionGenePPI for IMPDH1_GRM8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IMPDH1 | IMPDH2, DDX3X, HTRA1, GMNN, LAMP2, XRCC6, HOXB7, C17orf82, VAX2, POLL, TXNDC5, NR2E1, FASN, SPANXN3, TCL1B, CTPS1, DDX5, EDF1, GMPS, HMGCS1, NHP2L1, NOP9, SH3KBP1, UBL7, NTRK1, MYO1C, XRCC3, EMC2, SEC16A, MMGT1, DUSP21, SMCR8, WDR25, SDHC, ARHGEF39, TRIM6, ANKRD9, SLC25A44, FTSJ2, B3GNTL1, MTMR8, PIP5K1A, ABCB10, DCAF4, PUSL1, C4orf29, MOK, SKP2, ATG4D, DCAKD, STK19, FAM120B, MTCH2, ZRANB3, GUCD1, WDR76, PODXL, DPH1, GTPBP8, TMEM11, BCS1L, METTL22, PEX6, KLHDC8B, ACSF3, LCMT2, SLC25A14, IBA57, SOST, HSDL1, MTCH1, NDUFC2, KLHL2, GATA2, LRRC8E, CLPP, ZNF704, CHEK1, WEE1, RPS11, CDC73, SH3GL1 | GRM8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IMPDH1_GRM8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IMPDH1 | P20839 | DB00811 | Ribavirin | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156} | small molecule | approved |
| Hgene | IMPDH1 | P20839 | DB01024 | Mycophenolic acid | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156} | small molecule | approved |
| Hgene | IMPDH1 | P20839 | DB01033 | Mercaptopurine | Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156} | small molecule | approved |
| Tgene | GRM8 | O00222 | DB00142 | Glutamic Acid | Metabotropic glutamate receptor 8 | small molecule | approved|nutraceutical |
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RelatedDiseases for IMPDH1_GRM8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IMPDH1 | C1867299 | Retinitis Pigmentosa 10 | 3 | CTD_human;UNIPROT |
| Hgene | IMPDH1 | C0035334 | Retinitis Pigmentosa | 2 | CTD_human;HPO;ORPHANET |
| Hgene | IMPDH1 | C0339527 | Leber Congenital Amaurosis | 1 | CTD_human;ORPHANET |
| Hgene | IMPDH1 | C1840284 | LEBER CONGENITAL AMAUROSIS 11 | 1 | UNIPROT |
| Tgene | GRM8 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | GRM8 | C0001957 | Alcohol Withdrawal Delirium | 1 | PSYGENET |
| Tgene | GRM8 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | GRM8 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | GRM8 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | GRM8 | C0017639 | Gliosis | 1 | CTD_human |
| Tgene | GRM8 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | GRM8 | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |
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