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Fusion gene ID: 17441 |
FusionGeneSummary for IMMP1L_ELP4 |
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Fusion gene information | Fusion gene name: IMMP1L_ELP4 | Fusion gene ID: 17441 | Hgene | Tgene | Gene symbol | IMMP1L | ELP4 | Gene ID | 196294 | 26610 |
Gene name | inner mitochondrial membrane peptidase subunit 1 | elongator acetyltransferase complex subunit 4 | |
Synonyms | IMMP1|IMP1|IMP1-LIKE | AN|AN2|C11orf19|PAX6NEB|PAXNEB|dJ68P15A.1|hELP4 | |
Cytomap | 11p13 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | mitochondrial inner membrane protease subunit 1IMP1 inner mitochondrial membrane peptidase-like | elongator complex protein 4PAX6 neighbor gene proteinelongation protein 4 homolog | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q96LU5 | Q96EB1 | |
Ensembl transtripts involved in fusion gene | ENST00000526776, ENST00000532287, ENST00000534812, ENST00000278200, ENST00000533642, ENST00000528161, | ENST00000350638, ENST00000379163, ENST00000395934, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 5=100 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IMMP1L [Title/Abstract] AND ELP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ELP4 | GO:0006357 | regulation of transcription by RNA polymerase II | 11818576 |
Tgene | ELP4 | GO:0043966 | histone H3 acetylation | 11714725 |
Tgene | ELP4 | GO:0043967 | histone H4 acetylation | 11714725 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG433771 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000526776 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000526776 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000526776 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000532287 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000532287 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000532287 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000534812 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000534812 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000534812 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000278200 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000278200 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000278200 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000533642 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000533642 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000533642 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000528161 | ENST00000350638 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000528161 | ENST00000379163 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
5UTR-3CDS | ENST00000528161 | ENST00000395934 | IMMP1L | chr11 | 31531064 | - | ELP4 | chr11 | 31541601 | + |
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FusionProtFeatures for IMMP1L_ELP4 |
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Hgene | Tgene |
IMMP1L | ELP4 |
Catalyzes the removal of transit peptides required forthe targeting of proteins from the mitochondrial matrix, acrossthe inner membrane, into the inter-membrane space. Known toprocess the nuclear encoded protein DIABLO.{ECO:0000269|PubMed:15814844}. | Acts as subunit of the RNA polymerase II elongatorcomplex, which is a histone acetyltransferase component of the RNApolymerase II (Pol II) holoenzyme and is involved intranscriptional elongation. Elongator may play a role in chromatinremodeling and is involved in acetylation of histones H3 andprobably H4. {ECO:0000269|PubMed:11714725,ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:16713582}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IMMP1L_ELP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IMMP1L_ELP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IMMP1L | TSPAN5, ZER1, FAM117B | ELP4 | IKBKAP, ELP2, ELP3, HINFP, PPP1CC, CBX6, MMS19, SRP68, FAM96B, CIAO1, SHMT2, ELP6, PIPOX, SF3B3, ID2, CDH1, EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IMMP1L_ELP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IMMP1L_ELP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |