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Fusion gene ID: 17416 |
FusionGeneSummary for IL6_TMED10 |
Fusion gene summary |
Fusion gene information | Fusion gene name: IL6_TMED10 | Fusion gene ID: 17416 | Hgene | Tgene | Gene symbol | IL6 | TMED10 | Gene ID | 3569 | 10972 |
Gene name | interleukin 6 | transmembrane p24 trafficking protein 10 | |
Synonyms | BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6 | P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1 | |
Cytomap | 7p15.3 | 14q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-6B-cell differentiation factorB-cell stimulatory factor 2CTL differentiation factorhybridoma growth factorinterferon beta-2interleukin BSF-2 | transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P05231 | P49755 | |
Ensembl transtripts involved in fusion gene | ENST00000404625, ENST00000401651, ENST00000258743, ENST00000420258, ENST00000407492, ENST00000401630, ENST00000406575, | ENST00000303575, ENST00000557670, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 4=96 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IL6 [Title/Abstract] AND TMED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IL6 | GO:0001781 | neutrophil apoptotic process | 7595060 |
Hgene | IL6 | GO:0002384 | hepatic immune response | 2444978 |
Hgene | IL6 | GO:0002675 | positive regulation of acute inflammatory response | 2444978 |
Hgene | IL6 | GO:0006954 | inflammatory response | 10443688 |
Hgene | IL6 | GO:0008284 | positive regulation of cell proliferation | 2261637 |
Hgene | IL6 | GO:0010574 | regulation of vascular endothelial growth factor production | 8557680 |
Hgene | IL6 | GO:0010628 | positive regulation of gene expression | 19390056 |
Hgene | IL6 | GO:0019221 | cytokine-mediated signaling pathway | 2261637|12643274 |
Hgene | IL6 | GO:0032722 | positive regulation of chemokine production | 10510402 |
Hgene | IL6 | GO:0032755 | positive regulation of interleukin-6 production | 10510402 |
Hgene | IL6 | GO:0032966 | negative regulation of collagen biosynthetic process | 12419823 |
Hgene | IL6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 7508917 |
Hgene | IL6 | GO:0042102 | positive regulation of T cell proliferation | 3130269 |
Hgene | IL6 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 12643274|19390056 |
Hgene | IL6 | GO:0043065 | positive regulation of apoptotic process | 9949178 |
Hgene | IL6 | GO:0043066 | negative regulation of apoptotic process | 7595060 |
Hgene | IL6 | GO:0043410 | positive regulation of MAPK cascade | 7508917|12419823 |
Hgene | IL6 | GO:0045727 | positive regulation of translation | 16732314 |
Hgene | IL6 | GO:0045893 | positive regulation of transcription, DNA-templated | 7749983|16606666 |
Hgene | IL6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7508917|16946298|17324931 |
Hgene | IL6 | GO:0046427 | positive regulation of JAK-STAT cascade | 12419823|12552091|17324931 |
Hgene | IL6 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 10510402 |
Hgene | IL6 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 7508917 |
Hgene | IL6 | GO:0050871 | positive regulation of B cell activation | 3491322 |
Hgene | IL6 | GO:0051024 | positive regulation of immunoglobulin secretion | 3491322 |
Hgene | IL6 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 7749983 |
Hgene | IL6 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12419823 |
Hgene | IL6 | GO:0051384 | response to glucocorticoid | 10443688 |
Hgene | IL6 | GO:0051607 | defense response to virus | 3023045 |
Hgene | IL6 | GO:0070102 | interleukin-6-mediated signaling pathway | 12552091|16946298 |
Hgene | IL6 | GO:0070301 | cellular response to hydrogen peroxide | 19168699 |
Tgene | TMED10 | GO:0006886 | intracellular protein transport | 20427317 |
Tgene | TMED10 | GO:0035964 | COPI-coated vesicle budding | 10052452 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE619286 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000404625 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-intron | ENST00000404625 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-3UTR | ENST00000401651 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-intron | ENST00000401651 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-3UTR | ENST00000258743 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-intron | ENST00000258743 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-3UTR | ENST00000420258 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-intron | ENST00000420258 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-3UTR | ENST00000407492 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-intron | ENST00000407492 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-3UTR | ENST00000401630 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
5CDS-intron | ENST00000401630 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-3UTR | ENST00000406575 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
intron-intron | ENST00000406575 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
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FusionProtFeatures for IL6_TMED10 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
IL6 | TMED10 |
Cytokine with a wide variety of biological functions. Itis a potent inducer of the acute phase response. Plays anessential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocytedifferentiation. Acts on B-cells, T-cells, hepatocytes,hematopoietic progenitor cells and cells of the CNS. Required forthe generation of T(H)17 cells. Also acts as a myokine. It isdischarged into the bloodstream after muscle contraction and actsto increase the breakdown of fats and to improve insulinresistance. It induces myeloma and plasmacytoma growth and inducesnerve cells differentiation. | Involved in vesicular protein trafficking. Mainlyfunctions in the early secretory pathway. Thought to act as cargoreceptor at the lumenal side for incorporation of secretory cargomolecules into transport vesicles and to be involved in vesiclecoat formation at the cytoplasmic side. In COPII vesicle-mediatedanterograde transport involved in the transport of GPI-anchoredproteins and proposed to act together with TMED2 as their cargoreceptor; the function specifically implies SEC24C and SEC24D ofthe COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 andMPPE1 (By similarity). In COPI vesicle-mediated retrogradetransport involved in the biogenesis of COPI vesicles and vesiclecoat recruitment. On Golgi membranes, acts as primary receptor forARF1-GDP which is involved in COPI-vesicle formation. Increasescoatomer-dependent GTPase-activating activity of ARFGAP2. Involvedin trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to theplasma membrane thus contributing to receptor resensitization.Involved in trafficking of amyloid beta A4 protein and solubleAPP-beta release (independent of modulation of gamma-secretaseactivity). As part of the presenilin-dependent gamma-secretasecomplex regulates gamma-cleavages of the amyloid beta A4 proteinto yield amyloid-beta 40 (Abeta40). Involved in organization ofthe Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452,ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999,ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914,ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL6_TMED10 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL6_TMED10 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL6_TMED10 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | IL6 | P05231 | DB09036 | Siltuximab | Interleukin-6 | biotech | approved|investigational |
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RelatedDiseases for IL6_TMED10 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IL6 | C0021368 | Inflammation | 10 | CTD_human |
Hgene | IL6 | C0011581 | Depressive disorder | 6 | CTD_human;PSYGENET |
Hgene | IL6 | C0011206 | Delirium | 5 | PSYGENET |
Hgene | IL6 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | IL6 | C0033578 | Prostatic Neoplasms | 5 | CTD_human |
Hgene | IL6 | C0035126 | Reperfusion Injury | 5 | CTD_human |
Hgene | IL6 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | IL6 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | IL6 | C1458155 | Mammary Neoplasms | 4 | CTD_human |
Hgene | IL6 | C0015967 | Fever | 3 | CTD_human;HPO |
Hgene | IL6 | C0020429 | Hyperalgesia | 3 | CTD_human |
Hgene | IL6 | C0023290 | Leishmaniasis, Visceral | 3 | CTD_human |
Hgene | IL6 | C0026764 | Multiple Myeloma | 3 | CTD_human |
Hgene | IL6 | C0740392 | Infarction, Middle Cerebral Artery | 3 | CTD_human |
Hgene | IL6 | C0993582 | Arthritis, Experimental | 3 | CTD_human |
Hgene | IL6 | C2239176 | Liver carcinoma | 3 | CTD_human |
Hgene | IL6 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | IL6 | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Hgene | IL6 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | IL6 | C0007786 | Brain Ischemia | 2 | CTD_human |
Hgene | IL6 | C0009319 | Colitis | 2 | CTD_human |
Hgene | IL6 | C0010346 | Crohn Disease | 2 | CTD_human |
Hgene | IL6 | C0018801 | Heart failure | 2 | CTD_human |
Hgene | IL6 | C0020649 | Hypotension | 2 | CTD_human |
Hgene | IL6 | C0022876 | Premature Obstetric Labor | 2 | CTD_human |
Hgene | IL6 | C0027051 | Myocardial Infarction | 2 | CTD_human |
Hgene | IL6 | C0028754 | Obesity | 2 | CTD_human |
Hgene | IL6 | C0034069 | Pulmonary Fibrosis | 2 | CTD_human |
Hgene | IL6 | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
Hgene | IL6 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | IL6 | C0001925 | Albuminuria | 1 | CTD_human |
Hgene | IL6 | C0002622 | Amnesia | 1 | CTD_human |
Hgene | IL6 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | IL6 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | IL6 | C0004364 | Autoimmune Diseases | 1 | CTD_human;HPO |
Hgene | IL6 | C0005138 | Berylliosis | 1 | CTD_human |
Hgene | IL6 | C0006625 | Cachexia | 1 | CTD_human |
Hgene | IL6 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Hgene | IL6 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | IL6 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | IL6 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | IL6 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | IL6 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Hgene | IL6 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | IL6 | C0013604 | Edema | 1 | CTD_human |
Hgene | IL6 | C0014324 | Entamoebiasis | 1 | CTD_human |
Hgene | IL6 | C0017531 | Angiolymphoid hyperplasia | 1 | CTD_human |
Hgene | IL6 | C0017658 | Glomerulonephritis | 1 | CTD_human |
Hgene | IL6 | C0018681 | Headache | 1 | CTD_human |
Hgene | IL6 | C0018843 | Heat Stroke | 1 | CTD_human |
Hgene | IL6 | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
Hgene | IL6 | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
Hgene | IL6 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | IL6 | C0020437 | Hypercalcemia | 1 | CTD_human |
Hgene | IL6 | C0020500 | Hyperoxaluria | 1 | CTD_human |
Hgene | IL6 | C0020503 | Hyperparathyroidism, Secondary | 1 | CTD_human |
Hgene | IL6 | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | IL6 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | IL6 | C0022116 | Ischemia | 1 | CTD_human |
Hgene | IL6 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | IL6 | C0023281 | Leishmaniasis | 1 | CTD_human |
Hgene | IL6 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
Hgene | IL6 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | IL6 | C0023891 | Liver Cirrhosis, Alcoholic | 1 | CTD_human |
Hgene | IL6 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | IL6 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Hgene | IL6 | C0025290 | Aseptic Meningitis | 1 | CTD_human |
Hgene | IL6 | C0027540 | Necrosis | 1 | CTD_human |
Hgene | IL6 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | IL6 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | IL6 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | IL6 | C0029458 | Osteoporosis, Postmenopausal | 1 | CTD_human |
Hgene | IL6 | C0030567 | Parkinson Disease | 1 | CTD_human |
Hgene | IL6 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | IL6 | C0032226 | Pleural Diseases | 1 | CTD_human |
Hgene | IL6 | C0032231 | Pleurisy | 1 | CTD_human |
Hgene | IL6 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | IL6 | C0032963 | Pregnancy Complications, Cardiovascular | 1 | CTD_human |
Hgene | IL6 | C0033860 | Psoriasis | 1 | CTD_human |
Hgene | IL6 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Hgene | IL6 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | IL6 | C0036572 | Seizures | 1 | CTD_human |
Hgene | IL6 | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
Hgene | IL6 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | IL6 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | IL6 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Hgene | IL6 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Hgene | IL6 | C0085655 | Polymyositis | 1 | CTD_human |
Hgene | IL6 | C0151526 | Premature Birth | 1 | CTD_human |
Hgene | IL6 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | IL6 | C0162670 | Mitochondrial Myopathies | 1 | CTD_human |
Hgene | IL6 | C0162848 | Lichenoid Eruptions | 1 | CTD_human |
Hgene | IL6 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | IL6 | C0239981 | Hypoalbuminemia | 1 | CTD_human |
Hgene | IL6 | C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |
Hgene | IL6 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Hgene | IL6 | C0273115 | Lung Injury | 1 | CTD_human |
Hgene | IL6 | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
Hgene | IL6 | C0343755 | HIV Wasting Syndrome | 1 | CTD_human |
Hgene | IL6 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | IL6 | C0524620 | Metabolic Syndrome X | 1 | CTD_human |
Hgene | IL6 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
Hgene | IL6 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Hgene | IL6 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | IL6 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | IL6 | C2609414 | Acute kidney injury | 1 | CTD_human |