FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17386

FusionGeneSummary for IL2_TNFRSF17

check button Fusion gene summary
Fusion gene informationFusion gene name: IL2_TNFRSF17
Fusion gene ID: 17386
HgeneTgene
Gene symbol

IL2

TNFRSF17

Gene ID

3558

608

Gene nameinterleukin 2TNF receptor superfamily member 17
SynonymsIL-2|TCGF|lymphokineBCM|BCMA|CD269|TNFRSF13A
Cytomap

4q27

16p13.13

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-2T cell growth factoraldesleukininvolved in regulation of T-cell clonal expansiontumor necrosis factor receptor superfamily member 17B cell maturation antigenB-cell maturation factorB-cell maturation protein
Modification date2018052220180519
UniProtAcc

P60568

Q02223

Ensembl transtripts involved in fusion geneENST00000226730, ENST00000053243, 
ENST00000396495, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 4=24
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IL2 [Title/Abstract] AND TNFRSF17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL2

GO:0002366

leukocyte activation involved in immune response

16204630

HgeneIL2

GO:0002903

negative regulation of B cell apoptotic process

9184696

HgeneIL2

GO:0030890

positive regulation of B cell proliferation

9184696

HgeneIL2

GO:0032740

positive regulation of interleukin-17 production

16482511

HgeneIL2

GO:0042104

positive regulation of activated T cell proliferation

1830926|10072077

HgeneIL2

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

19088061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1Z14955IL2chr4

123374865

-TNFRSF17chr16

12059189

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000226730ENST00000053243IL2chr4

123374865

-TNFRSF17chr16

12059189

+
Frame-shitENST00000226730ENST00000396495IL2chr4

123374865

-TNFRSF17chr16

12059189

+

Top

FusionProtFeatures for IL2_TNFRSF17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL2

P60568

TNFRSF17

Q02223

Produced by T-cells in response to antigenic ormitogenic stimulation, this protein is required for T-cellproliferation and other activities crucial to regulation of theimmune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.Promotes B-cell survival and plays a role in the regulation ofhumoral immunity. Activates NF-kappa-B and JNK.{ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733,ECO:0000269|PubMed:10973284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IL2_TNFRSF17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IL2_TNFRSF17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IL2_TNFRSF17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIL2P60568DB00852PseudoephedrineInterleukin-2small moleculeapproved
HgeneIL2P60568DB01327CefazolinInterleukin-2small moleculeapproved
HgeneIL2P60568DB05676ApremilastInterleukin-2small moleculeapproved|investigational

Top

RelatedDiseases for IL2_TNFRSF17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL2C0025202melanoma22CTD_human
HgeneIL2C0022665Kidney Neoplasm4CTD_human
HgeneIL2C0024121Lung Neoplasms3CTD_human
HgeneIL2C0027659Neoplasms, Experimental3CTD_human
HgeneIL2C0036341Schizophrenia3PSYGENET
HgeneIL2C0004352Autistic Disorder2CTD_human
HgeneIL2C0005695Bladder Neoplasm2CTD_human
HgeneIL2C0017658Glomerulonephritis2CTD_human
HgeneIL2C0001175Acquired Immunodeficiency Syndrome1CTD_human
HgeneIL2C0002622Amnesia1CTD_human
HgeneIL2C0002871Anemia1CTD_human
HgeneIL2C0003123Anorexia1CTD_human
HgeneIL2C0004093Asthenia1CTD_human
HgeneIL2C0006118Brain Neoplasms1CTD_human
HgeneIL2C0014324Entamoebiasis1CTD_human
HgeneIL2C0015967Fever1CTD_human
HgeneIL2C0017636Glioblastoma1CTD_human
HgeneIL2C0019693HIV Infections1CTD_human
HgeneIL2C0020649Hypotension1CTD_human
HgeneIL2C0023418leukemia1CTD_human
HgeneIL2C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneIL2C0023530Leukopenia1CTD_human
HgeneIL2C0023903Liver neoplasms1CTD_human
HgeneIL2C0027627Neoplasm Metastasis1CTD_human
HgeneIL2C0027726Nephrotic Syndrome1CTD_human
HgeneIL2C0030193Pain1CTD_human
HgeneIL2C0033578Prostatic Neoplasms1CTD_human
HgeneIL2C0036349Paranoid Schizophrenia1PSYGENET
HgeneIL2C0042258Vaginal Neoplasms1CTD_human
HgeneIL2C0162820Dermatitis, Allergic Contact1CTD_human
HgeneIL2C0241910Hepatitis, Autoimmune1CTD_human
HgeneIL2C0242596Neoplasm, Residual1CTD_human
HgeneIL2C0424295Hyperactive behavior1CTD_human
HgeneIL2C1269683Major Depressive Disorder1CTD_human