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Fusion gene ID: 17386 |
FusionGeneSummary for IL2_TNFRSF17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IL2_TNFRSF17 | Fusion gene ID: 17386 | Hgene | Tgene | Gene symbol | IL2 | TNFRSF17 | Gene ID | 3558 | 608 |
| Gene name | interleukin 2 | TNF receptor superfamily member 17 | |
| Synonyms | IL-2|TCGF|lymphokine | BCM|BCMA|CD269|TNFRSF13A | |
| Cytomap | 4q27 | 16p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-2T cell growth factoraldesleukininvolved in regulation of T-cell clonal expansion | tumor necrosis factor receptor superfamily member 17B cell maturation antigenB-cell maturation factorB-cell maturation protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P60568 | Q02223 | |
| Ensembl transtripts involved in fusion gene | ENST00000226730, | ENST00000053243, ENST00000396495, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 4=24 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IL2 [Title/Abstract] AND TNFRSF17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IL2 | GO:0002366 | leukocyte activation involved in immune response | 16204630 |
| Hgene | IL2 | GO:0002903 | negative regulation of B cell apoptotic process | 9184696 |
| Hgene | IL2 | GO:0030890 | positive regulation of B cell proliferation | 9184696 |
| Hgene | IL2 | GO:0032740 | positive regulation of interleukin-17 production | 16482511 |
| Hgene | IL2 | GO:0042104 | positive regulation of activated T cell proliferation | 1830926|10072077 |
| Hgene | IL2 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 19088061 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | Z14955 | IL2 | chr4 | 123374865 | - | TNFRSF17 | chr16 | 12059189 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000226730 | ENST00000053243 | IL2 | chr4 | 123374865 | - | TNFRSF17 | chr16 | 12059189 | + |
| Frame-shift | ENST00000226730 | ENST00000396495 | IL2 | chr4 | 123374865 | - | TNFRSF17 | chr16 | 12059189 | + |
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FusionProtFeatures for IL2_TNFRSF17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IL2 | TNFRSF17 |
| Produced by T-cells in response to antigenic ormitogenic stimulation, this protein is required for T-cellproliferation and other activities crucial to regulation of theimmune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.Promotes B-cell survival and plays a role in the regulation ofhumoral immunity. Activates NF-kappa-B and JNK.{ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733,ECO:0000269|PubMed:10973284}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL2_TNFRSF17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL2_TNFRSF17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL2_TNFRSF17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IL2 | P60568 | DB00852 | Pseudoephedrine | Interleukin-2 | small molecule | approved |
| Hgene | IL2 | P60568 | DB01327 | Cefazolin | Interleukin-2 | small molecule | approved |
| Hgene | IL2 | P60568 | DB05676 | Apremilast | Interleukin-2 | small molecule | approved|investigational |
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RelatedDiseases for IL2_TNFRSF17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IL2 | C0025202 | melanoma | 22 | CTD_human |
| Hgene | IL2 | C0022665 | Kidney Neoplasm | 4 | CTD_human |
| Hgene | IL2 | C0024121 | Lung Neoplasms | 3 | CTD_human |
| Hgene | IL2 | C0027659 | Neoplasms, Experimental | 3 | CTD_human |
| Hgene | IL2 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | IL2 | C0004352 | Autistic Disorder | 2 | CTD_human |
| Hgene | IL2 | C0005695 | Bladder Neoplasm | 2 | CTD_human |
| Hgene | IL2 | C0017658 | Glomerulonephritis | 2 | CTD_human |
| Hgene | IL2 | C0001175 | Acquired Immunodeficiency Syndrome | 1 | CTD_human |
| Hgene | IL2 | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | IL2 | C0002871 | Anemia | 1 | CTD_human |
| Hgene | IL2 | C0003123 | Anorexia | 1 | CTD_human |
| Hgene | IL2 | C0004093 | Asthenia | 1 | CTD_human |
| Hgene | IL2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Hgene | IL2 | C0014324 | Entamoebiasis | 1 | CTD_human |
| Hgene | IL2 | C0015967 | Fever | 1 | CTD_human |
| Hgene | IL2 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | IL2 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | IL2 | C0020649 | Hypotension | 1 | CTD_human |
| Hgene | IL2 | C0023418 | leukemia | 1 | CTD_human |
| Hgene | IL2 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Hgene | IL2 | C0023530 | Leukopenia | 1 | CTD_human |
| Hgene | IL2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | IL2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | IL2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Hgene | IL2 | C0030193 | Pain | 1 | CTD_human |
| Hgene | IL2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | IL2 | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
| Hgene | IL2 | C0042258 | Vaginal Neoplasms | 1 | CTD_human |
| Hgene | IL2 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Hgene | IL2 | C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |
| Hgene | IL2 | C0242596 | Neoplasm, Residual | 1 | CTD_human |
| Hgene | IL2 | C0424295 | Hyperactive behavior | 1 | CTD_human |
| Hgene | IL2 | C1269683 | Major Depressive Disorder | 1 | CTD_human |
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