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Fusion gene ID: 17374 |
FusionGeneSummary for IL1RL2_IL1R2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IL1RL2_IL1R2 | Fusion gene ID: 17374 | Hgene | Tgene | Gene symbol | IL1RL2 | IL1R2 | Gene ID | 8808 | 7850 |
| Gene name | interleukin 1 receptor like 2 | interleukin 1 receptor type 2 | |
| Synonyms | IL-1Rrp2|IL-36R|IL1R-rp2|IL1RRP2 | CD121b|CDw121b|IL-1R-2|IL-1RT-2|IL-1RT2|IL1R2c|IL1RB | |
| Cytomap | 2q12.1 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-1 receptor-like 2IL-1 receptor-related protein 2IL-36 receptorinterleukin-1 receptor-related protein 2 | interleukin-1 receptor type 2CD121 antigen-like family member BIL-1 type II receptorIL-1R-betaantigen CDw121binterleukin 1 receptor type II variant 3interleukin-1 receptor betainterleukin-1 receptor type IItype II interleukin-1 receptor, beta | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9HB29 | P27930 | |
| Ensembl transtripts involved in fusion gene | ENST00000264257, ENST00000441515, ENST00000481806, ENST00000539491, | ENST00000332549, ENST00000393414, ENST00000441002, ENST00000485335, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 5=100 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IL1RL2 [Title/Abstract] AND IL1R2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A1FD-01A | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000264257 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000264257 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000264257 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 5CDS-intron | ENST00000264257 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000441515 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000441515 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000441515 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 5CDS-intron | ENST00000441515 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 3UTR-3CDS | ENST00000481806 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 3UTR-3CDS | ENST00000481806 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 3UTR-3CDS | ENST00000481806 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 3UTR-intron | ENST00000481806 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000539491 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000539491 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| Frame-shift | ENST00000539491 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
| 5CDS-intron | ENST00000539491 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
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FusionProtFeatures for IL1RL2_IL1R2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IL1RL2 | IL1R2 |
| Receptor for interleukin-36 (IL36A, IL36B and IL36G).After binding to interleukin-36 associates with the coreceptorIL1RAP to form the interleukin-36 receptor complex which mediatesinterleukin-36-dependent activation of NF-kappa-B, MAPK and otherpathways (By similarity). The IL-36 signaling system is thought tobe present in epithelial barriers and to take part in localinflammatory response; it is similar to the IL-1 system. Seems tobe involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7,ECO:0000269|PubMed:11466363}. | Non-signaling receptor for IL1A, IL1B and IL1RN. ReducesIL1B activities. Serves as a decoy receptor by competetive bindingto IL1B and preventing its binding to IL1R1. Also modulatescellular response through non-signaling association with IL1RAPafter binding to IL1B. IL1R2 (membrane and secreted forms)preferentially binds IL1B and poorly IL1A and IL1RN. The secretedIL1R2 recruits secreted IL1RAP with high affinity; this complexformation may be the dominant mechanism for neutralization of IL1Bby secreted/soluble receptors. {ECO:0000269|PubMed:10975853,ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776,ECO:0000269|PubMed:9862719}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL1RL2_IL1R2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL1RL2_IL1R2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IL1RL2 | TOLLIP, POTEI, DNAJC6, MYO1F, MICAL1, ACTB, GET4, USP2, STAMBP, OTUB1, RNF125 | IL1R2 | IL1RN, IL1A, EXOC6B, CCDC51, EXOC6, NUDT16, EXOC5, EXOC7, EXOC1, TRMU, EXOC2, LONP2, EXOC3, NDUFA12, EXOC8, QSOX1, SEZ6L2, DSTYK, NDUFS4, SCRIB, CBWD3, RHOBTB3, EXOC4, MYADM, LRRC1, ATP2B2, RSPRY1, SLC30A5, GNPAT, ATL2, CISD2, DNM3, NLRX1, OCRL, TBCD, KIAA0391, AARS2, ORC4, KIAA1524 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL1RL2_IL1R2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL1RL2_IL1R2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IL1R2 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | IL1R2 | C0020517 | Hypersensitivity | 1 | CTD_human |
| Tgene | IL1R2 | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | IL1R2 | C0032285 | Pneumonia | 1 | CTD_human |
| Tgene | IL1R2 | C0038013 | Ankylosing spondylitis | 1 | CTD_human |
| Tgene | IL1R2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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