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Fusion gene ID: 17374 |
FusionGeneSummary for IL1RL2_IL1R2 |
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Fusion gene information | Fusion gene name: IL1RL2_IL1R2 | Fusion gene ID: 17374 | Hgene | Tgene | Gene symbol | IL1RL2 | IL1R2 | Gene ID | 8808 | 7850 |
Gene name | interleukin 1 receptor like 2 | interleukin 1 receptor type 2 | |
Synonyms | IL-1Rrp2|IL-36R|IL1R-rp2|IL1RRP2 | CD121b|CDw121b|IL-1R-2|IL-1RT-2|IL-1RT2|IL1R2c|IL1RB | |
Cytomap | 2q12.1 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-1 receptor-like 2IL-1 receptor-related protein 2IL-36 receptorinterleukin-1 receptor-related protein 2 | interleukin-1 receptor type 2CD121 antigen-like family member BIL-1 type II receptorIL-1R-betaantigen CDw121binterleukin 1 receptor type II variant 3interleukin-1 receptor betainterleukin-1 receptor type IItype II interleukin-1 receptor, beta | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9HB29 | P27930 | |
Ensembl transtripts involved in fusion gene | ENST00000264257, ENST00000441515, ENST00000481806, ENST00000539491, | ENST00000332549, ENST00000393414, ENST00000441002, ENST00000485335, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 5=100 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IL1RL2 [Title/Abstract] AND IL1R2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A1FD-01A | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264257 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000264257 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000264257 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
5CDS-intron | ENST00000264257 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000441515 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000441515 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000441515 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
5CDS-intron | ENST00000441515 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
3UTR-3CDS | ENST00000481806 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
3UTR-3CDS | ENST00000481806 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
3UTR-3CDS | ENST00000481806 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
3UTR-intron | ENST00000481806 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000539491 | ENST00000332549 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000539491 | ENST00000393414 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
Frame-shift | ENST00000539491 | ENST00000441002 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
5CDS-intron | ENST00000539491 | ENST00000485335 | IL1RL2 | chr2 | 102828634 | + | IL1R2 | chr2 | 102636100 | + |
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FusionProtFeatures for IL1RL2_IL1R2 |
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Hgene | Tgene |
IL1RL2 | IL1R2 |
Receptor for interleukin-36 (IL36A, IL36B and IL36G).After binding to interleukin-36 associates with the coreceptorIL1RAP to form the interleukin-36 receptor complex which mediatesinterleukin-36-dependent activation of NF-kappa-B, MAPK and otherpathways (By similarity). The IL-36 signaling system is thought tobe present in epithelial barriers and to take part in localinflammatory response; it is similar to the IL-1 system. Seems tobe involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7,ECO:0000269|PubMed:11466363}. | Non-signaling receptor for IL1A, IL1B and IL1RN. ReducesIL1B activities. Serves as a decoy receptor by competetive bindingto IL1B and preventing its binding to IL1R1. Also modulatescellular response through non-signaling association with IL1RAPafter binding to IL1B. IL1R2 (membrane and secreted forms)preferentially binds IL1B and poorly IL1A and IL1RN. The secretedIL1R2 recruits secreted IL1RAP with high affinity; this complexformation may be the dominant mechanism for neutralization of IL1Bby secreted/soluble receptors. {ECO:0000269|PubMed:10975853,ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776,ECO:0000269|PubMed:9862719}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL1RL2_IL1R2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL1RL2_IL1R2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IL1RL2 | TOLLIP, POTEI, DNAJC6, MYO1F, MICAL1, ACTB, GET4, USP2, STAMBP, OTUB1, RNF125 | IL1R2 | IL1RN, IL1A, EXOC6B, CCDC51, EXOC6, NUDT16, EXOC5, EXOC7, EXOC1, TRMU, EXOC2, LONP2, EXOC3, NDUFA12, EXOC8, QSOX1, SEZ6L2, DSTYK, NDUFS4, SCRIB, CBWD3, RHOBTB3, EXOC4, MYADM, LRRC1, ATP2B2, RSPRY1, SLC30A5, GNPAT, ATL2, CISD2, DNM3, NLRX1, OCRL, TBCD, KIAA0391, AARS2, ORC4, KIAA1524 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL1RL2_IL1R2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL1RL2_IL1R2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IL1R2 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Tgene | IL1R2 | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | IL1R2 | C0023895 | Liver diseases | 1 | CTD_human |
Tgene | IL1R2 | C0032285 | Pneumonia | 1 | CTD_human |
Tgene | IL1R2 | C0038013 | Ankylosing spondylitis | 1 | CTD_human |
Tgene | IL1R2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |