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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17372

FusionGeneSummary for IL1RAP_TP63

check button Fusion gene summary
Fusion gene informationFusion gene name: IL1RAP_TP63
Fusion gene ID: 17372
HgeneTgene
Gene symbol

IL1RAP

TP63

Gene ID

3556

8626

Gene nameinterleukin 1 receptor accessory proteintumor protein p63
SynonymsC3orf13|IL-1RAcP|IL1R3AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Cytomap

3q28

3q28

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor accessory proteinIL-1 receptor accessory proteinIL-1R3interleukin-1 receptor 3interleukin-1 receptor accessory protein betatumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
Modification date2018052720180521
UniProtAcc

Q9NPH3

Q9H3D4

Ensembl transtripts involved in fusion geneENST00000412504, ENST00000072516, 
ENST00000443369, ENST00000439062, 
ENST00000447382, ENST00000422485, 
ENST00000434491, ENST00000422940, 
ENST00000317757, ENST00000465496, 
ENST00000264731, ENST00000382063, 
ENST00000418709, ENST00000320472, 
ENST00000392460, ENST00000440651, 
ENST00000354600, ENST00000437221, 
ENST00000392463, ENST00000392461, 
ENST00000456148, ENST00000449992, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 5 X 4=120
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL1RAP [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

TgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

TgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

TgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-39-5035-01AIL1RAPchr3

190232008

+TP63chr3

189526061

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000412504ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000412504ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000072516ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000072516ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000443369ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000443369ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000439062ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000439062ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000447382ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000447382ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000422485ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422485ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000434491ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000434491ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000422940ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000422940ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-3CDSENST00000317757ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
5UTR-intronENST00000317757ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-3CDSENST00000465496ENST00000264731IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000382063IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000418709IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000320472IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000392460IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000440651IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000354600IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000437221IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000392463IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000392461IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000456148IL1RAPchr3

190232008

+TP63chr3

189526061

+
3UTR-intronENST00000465496ENST00000449992IL1RAPchr3

190232008

+TP63chr3

189526061

+

Top

FusionProtFeatures for IL1RAP_TP63


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL1RAP

Q9NPH3

TP63

Q9H3D4

Coreceptor for IL1RL2 in the IL-36 signaling system (Bysimilarity). Coreceptor with IL1R1 in the IL-1 signaling system.Associates with IL1R1 bound to IL1B to form the high affinityinterleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signalinginvolves the recruitment of adapter molecules such as TOLLIP,MYD88, and IRAK1 or IRAK2 via the respective TIR domains of thereceptor/coreceptor subunits. Recruits TOLLIP to the signalingcomplex. Does not bind to interleukin-1 alone; binding of IL1RN toIL1R1, prevents its association with IL1R1 to form a signalingcomplex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor.Coreceptor for IL1RL1 in the IL-33 signaling system. Canbidirectionally induce pre- and postsynaptic differentiation ofneurons by trans-synaptically binding to PTPRD (By similarity).May play a role in IL1B-mediated costimulation of IFNG productionfrom T-helper 1 (Th1) cells (Probable).{ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889,ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850,ECO:0000305|PubMed:19836339}. Isoform 2: Associates with secreted ligand-bound IL1R2and increases the affinity of secreted IL1R2 for IL1B; thiscomplex formation may be the dominant mechanism for neutralizationof IL1B by secreted/soluble receptors (PubMed:12530978). Enhancesthe ability of secreted IL1R1 to inhibit IL-33 signaling (Bysimilarity). {ECO:0000250|UniProtKB:Q61730,ECO:0000269|PubMed:12530978}. Isoform 4: Unable to mediate canonical IL-1 signaling(PubMed:19481478). Required for Src phosphorylation by IL1B. Maybe involved in IL1B-potentiated NMDA-induced calcium influx inneurons (By similarity). {ECO:0000250|UniProtKB:Q61730,ECO:0000269|PubMed:19481478}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IL1RAP_TP63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IL1RAP_TP63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IL1RAPTOLLIP, IL1R1, IRAK1, STAT3, RAC1, IL18R1, TIRAP, MYD88, MARCH8, TICAM2, PRPF40A, KPNA1, MC4R, PRKCI, CCNI, KRAS, HAVCR2, PCDHA12, PCDHGB4TP63HNRNPAB, GNB2L1, SCAF4, YAP1, HIPK2, BTRC, ADH5, AGBL2, ASPM, BRD8, NPRL3, TRAPPC11, CDT1, DAB2IP, DDX23, DNAJB6, DPH1, AGO1, AGO2, GAS8, IGF2BP1, LOC613037, JPH1, MTHFSD, MYL9, N4BP2, PIWIL1, RNF38, SMARCD2, TRMT11, EMX1, ITCH, MDM2, MDM4, WWP1, RELA, BRCA1, CHUK, IKBKB, FBXW7, CDKN2A, CDKN1A, TP53, RBL2, SFN, UBE2I, SUMO1, UBE4B, DAXX, PML, RCHY1, WWOX, FAS, CAD, FLNC, DHX9, SEC24C, VCP, SACS, PSMD2, HNRNPR, GOLGA4, HSPA5, FUS, A2M, SYNCRIP, ZNF676, TP63, CPSF6, PLS3, KRT5, CARM1, HNRNPL, CCT8, NONO, HNRNPK, KRT6C, TUBA1C, ATP5A1, RPL3, EEF1A1, RPSA, ZBTB4, HNRNPCL1, HNRNPA3, MAP1A, RPLP0, HIST1H1D, UACA, SNRPA, UPF2, CENPE, SAFB, S1PR5, RPL24, RPL13A, RPL12, MYLPF, HSP90AB1, ETV4, CEBPB, NFYA, NFKB1, STK11, NIPSNAP3A, ORM1, CCNC, ITIH4, BAG6, GCGR, HP, HPX, COPS6, SLC35A3, PINX1, SMAD3, RNF144B, EP300, KAT2B, CEP83, CHEK2, TP73, SH3KBP1, RPH3A, FOXK1, FOXK2, PEX14, ATF3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IL1RAP_TP63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IL1RAP_TP63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL1RAPC0023895Liver diseases1CTD_human
TgeneTP63C1785148RAPP-HODGKIN SYNDROME6CTD_human;ORPHANET;UNIPROT
TgeneTP63C1858562ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 35CTD_human;UNIPROT
TgeneTP63C0406709Hay-Wells syndrome3CTD_human;UNIPROT
TgeneTP63C0024121Lung Neoplasms2CTD_human
TgeneTP63C1854442SPLIT-HAND/FOOT MALFORMATION 42CTD_human;UNIPROT
TgeneTP63C0001418Adenocarcinoma1CTD_human
TgeneTP63C0006145Breast Diseases1CTD_human
TgeneTP63C0007137Squamous cell carcinoma1CTD_human
TgeneTP63C0007621Neoplastic Cell Transformation1CTD_human
TgeneTP63C0008924Cleft Lip1CTD_human;HPO;ORPHANET
TgeneTP63C0008925Cleft Palate1CTD_human;HPO
TgeneTP63C0009404Colorectal Neoplasms1CTD_human
TgeneTP63C0016508Congenital Foot Deformity1CTD_human
TgeneTP63C0018566Congenital Hand Deformities1CTD_human
TgeneTP63C0027627Neoplasm Metastasis1CTD_human
TgeneTP63C0030297Pancreatic Neoplasm1CTD_human
TgeneTP63C0037268Skin Abnormalities1CTD_human
TgeneTP63C0038987Sweat Gland Neoplasms1CTD_human
TgeneTP63C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTP63C0206720Squamous Cell Neoplasms1CTD_human
TgeneTP63C0206762Limb Deformities, Congenital1CTD_human
TgeneTP63C0376634Craniofacial Abnormalities1CTD_human
TgeneTP63C0406704Rudiger syndrome 11CTD_human;ORPHANET
TgeneTP63C0919267ovarian neoplasm1CTD_human
TgeneTP63C1720887Female Urogenital Diseases1CTD_human
TgeneTP63C1863204ADULT SYNDROME1CTD_human;ORPHANET;UNIPROT
TgeneTP63C1863753LIMB-MAMMARY SYNDROME1CTD_human;ORPHANET