	FusionGeneSummary
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Fusion gene ID: 17372

FusionGeneSummary for IL1RAP_TP63

Fusion gene summary

Fusion gene information	Fusion gene name: IL1RAP_TP63
	Fusion gene ID: 17372
		Hgene	Tgene
	Gene symbol	IL1RAP	TP63
	Gene ID	3556	8626
	Gene name	interleukin 1 receptor accessory protein	tumor protein p63
	Synonyms	C3orf13\|IL-1RAcP\|IL1R3	AIS\|B(p51A)\|B(p51B)\|EEC3\|KET\|LMS\|NBP\|OFC8\|RHS\|SHFM4\|TP53CP\|TP53L\|TP73L\|p40\|p51\|p53CP\|p63\|p73H\|p73L
	Cytomap	3q28	3q28
	Type of gene	protein-coding	protein-coding
	Description	interleukin-1 receptor accessory proteinIL-1 receptor accessory proteinIL-1R3interleukin-1 receptor 3interleukin-1 receptor accessory protein beta	tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
	Modification date	20180527	20180521
	UniProtAcc	Q9NPH3	Q9H3D4
	Ensembl transtripts involved in fusion gene	ENST00000412504, ENST00000072516, ENST00000443369, ENST00000439062, ENST00000447382, ENST00000422485, ENST00000434491, ENST00000422940, ENST00000317757, ENST00000465496,	ENST00000264731, ENST00000382063, ENST00000418709, ENST00000320472, ENST00000392460, ENST00000440651, ENST00000354600, ENST00000437221, ENST00000392463, ENST00000392461, ENST00000456148, ENST00000449992,
Fusion gene scores	* DoF score	5 X 4 X 3=60	6 X 5 X 4=120
	# samples	6	6
	** MAII score	log2(6/60*10)=0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IL1RAP [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TP63	GO:0045747	positive regulation of Notch signaling pathway	11641404
Tgene	TP63	GO:0045892	negative regulation of transcription, DNA-templated	12446784
Tgene	TP63	GO:0045893	positive regulation of transcription, DNA-templated	12446784\|16343436
Tgene	TP63	GO:0045944	positive regulation of transcription by RNA polymerase II	22521434
Tgene	TP63	GO:2000271	positive regulation of fibroblast apoptotic process	9774969

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-39-5035-01A	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000412504	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000072516	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000443369	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000439062	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000447382	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000422485	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000434491	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000422940	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000317757	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-3CDS	ENST00000465496	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+

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FusionProtFeatures for IL1RAP_TP63

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IL1RAP Q9NPH3	TP63 Q9H3D4
Coreceptor for IL1RL2 in the IL-36 signaling system (Bysimilarity). Coreceptor with IL1R1 in the IL-1 signaling system.Associates with IL1R1 bound to IL1B to form the high affinityinterleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signalinginvolves the recruitment of adapter molecules such as TOLLIP,MYD88, and IRAK1 or IRAK2 via the respective TIR domains of thereceptor/coreceptor subunits. Recruits TOLLIP to the signalingcomplex. Does not bind to interleukin-1 alone; binding of IL1RN toIL1R1, prevents its association with IL1R1 to form a signalingcomplex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor.Coreceptor for IL1RL1 in the IL-33 signaling system. Canbidirectionally induce pre- and postsynaptic differentiation ofneurons by trans-synaptically binding to PTPRD (By similarity).May play a role in IL1B-mediated costimulation of IFNG productionfrom T-helper 1 (Th1) cells (Probable).{ECO:0000250\|UniProtKB:Q61730, ECO:0000269\|PubMed:10799889,ECO:0000269\|PubMed:9371760, ECO:0000305\|PubMed:10653850,ECO:0000305\|PubMed:19836339}. Isoform 2: Associates with secreted ligand-bound IL1R2and increases the affinity of secreted IL1R2 for IL1B; thiscomplex formation may be the dominant mechanism for neutralizationof IL1B by secreted/soluble receptors (PubMed:12530978). Enhancesthe ability of secreted IL1R1 to inhibit IL-33 signaling (Bysimilarity). {ECO:0000250\|UniProtKB:Q61730,ECO:0000269\|PubMed:12530978}. Isoform 4: Unable to mediate canonical IL-1 signaling(PubMed:19481478). Required for Src phosphorylation by IL1B. Maybe involved in IL1B-potentiated NMDA-induced calcium influx inneurons (By similarity). {ECO:0000250\|UniProtKB:Q61730,ECO:0000269\|PubMed:19481478}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for IL1RAP_TP63

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IL1RAP_TP63

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
IL1RAP	TOLLIP, IL1R1, IRAK1, STAT3, RAC1, IL18R1, TIRAP, MYD88, MARCH8, TICAM2, PRPF40A, KPNA1, MC4R, PRKCI, CCNI, KRAS, HAVCR2, PCDHA12, PCDHGB4	TP63	HNRNPAB, GNB2L1, SCAF4, YAP1, HIPK2, BTRC, ADH5, AGBL2, ASPM, BRD8, NPRL3, TRAPPC11, CDT1, DAB2IP, DDX23, DNAJB6, DPH1, AGO1, AGO2, GAS8, IGF2BP1, LOC613037, JPH1, MTHFSD, MYL9, N4BP2, PIWIL1, RNF38, SMARCD2, TRMT11, EMX1, ITCH, MDM2, MDM4, WWP1, RELA, BRCA1, CHUK, IKBKB, FBXW7, CDKN2A, CDKN1A, TP53, RBL2, SFN, UBE2I, SUMO1, UBE4B, DAXX, PML, RCHY1, WWOX, FAS, CAD, FLNC, DHX9, SEC24C, VCP, SACS, PSMD2, HNRNPR, GOLGA4, HSPA5, FUS, A2M, SYNCRIP, ZNF676, TP63, CPSF6, PLS3, KRT5, CARM1, HNRNPL, CCT8, NONO, HNRNPK, KRT6C, TUBA1C, ATP5A1, RPL3, EEF1A1, RPSA, ZBTB4, HNRNPCL1, HNRNPA3, MAP1A, RPLP0, HIST1H1D, UACA, SNRPA, UPF2, CENPE, SAFB, S1PR5, RPL24, RPL13A, RPL12, MYLPF, HSP90AB1, ETV4, CEBPB, NFYA, NFKB1, STK11, NIPSNAP3A, ORM1, CCNC, ITIH4, BAG6, GCGR, HP, HPX, COPS6, SLC35A3, PINX1, SMAD3, RNF144B, EP300, KAT2B, CEP83, CHEK2, TP73, SH3KBP1, RPH3A, FOXK1, FOXK2, PEX14, ATF3

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for IL1RAP_TP63

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IL1RAP_TP63

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	IL1RAP	C0023895	Liver diseases	1	CTD_human
Tgene	TP63	C1785148	RAPP-HODGKIN SYNDROME	6	CTD_human;ORPHANET;UNIPROT
Tgene	TP63	C1858562	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3	5	CTD_human;UNIPROT
Tgene	TP63	C0406709	Hay-Wells syndrome	3	CTD_human;UNIPROT
Tgene	TP63	C0024121	Lung Neoplasms	2	CTD_human
Tgene	TP63	C1854442	SPLIT-HAND/FOOT MALFORMATION 4	2	CTD_human;UNIPROT
Tgene	TP63	C0001418	Adenocarcinoma	1	CTD_human
Tgene	TP63	C0006145	Breast Diseases	1	CTD_human
Tgene	TP63	C0007137	Squamous cell carcinoma	1	CTD_human
Tgene	TP63	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	TP63	C0008924	Cleft Lip	1	CTD_human;HPO;ORPHANET
Tgene	TP63	C0008925	Cleft Palate	1	CTD_human;HPO
Tgene	TP63	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	TP63	C0016508	Congenital Foot Deformity	1	CTD_human
Tgene	TP63	C0018566	Congenital Hand Deformities	1	CTD_human
Tgene	TP63	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	TP63	C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene	TP63	C0037268	Skin Abnormalities	1	CTD_human
Tgene	TP63	C0038987	Sweat Gland Neoplasms	1	CTD_human
Tgene	TP63	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	TP63	C0206720	Squamous Cell Neoplasms	1	CTD_human
Tgene	TP63	C0206762	Limb Deformities, Congenital	1	CTD_human
Tgene	TP63	C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene	TP63	C0406704	Rudiger syndrome 1	1	CTD_human;ORPHANET
Tgene	TP63	C0919267	ovarian neoplasm	1	CTD_human
Tgene	TP63	C1720887	Female Urogenital Diseases	1	CTD_human
Tgene	TP63	C1863204	ADULT SYNDROME	1	CTD_human;ORPHANET;UNIPROT
Tgene	TP63	C1863753	LIMB-MAMMARY SYNDROME	1	CTD_human;ORPHANET

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Fusion gene ID: 17372

FusionGeneSummary for IL1RAP_TP63

FusionProtFeatures for IL1RAP_TP63

FusionGeneSequence for IL1RAP_TP63

FusionGenePPI for IL1RAP_TP63

RelatedDrugs for IL1RAP_TP63

RelatedDiseases for IL1RAP_TP63