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Fusion gene ID: 17368 |
FusionGeneSummary for IL1RAPL2_STK39 |
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Fusion gene information | Fusion gene name: IL1RAPL2_STK39 | Fusion gene ID: 17368 | Hgene | Tgene | Gene symbol | IL1RAPL2 | STK39 | Gene ID | 26280 | 27347 |
Gene name | interleukin 1 receptor accessory protein like 2 | serine/threonine kinase 39 | |
Synonyms | IL-1R9|IL1R9|IL1RAPL-2|TIGIRR-1 | DCHT|PASK|SPAK | |
Cytomap | Xq22.3 | 2q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | X-linked interleukin-1 receptor accessory protein-like 2IL-1 receptor accessory protein-like 2IL-1R-9IL1RAPL-2-related proteininterleukin 1 receptor 9three immunoglobulin domain-containing IL-1 receptor-related 1 | STE20/SPS1-related proline-alanine-rich protein kinaseSTE20/SPS1 homologSte20-like protein kinaseproline-alanine-rich STE20-related kinaseserine threonine kinase 39 (STE20/SPS1 homolog, yeast)serine/threonine-protein kinase 39small intestine SPAK-li | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NP60 | Q9UEW8 | |
Ensembl transtripts involved in fusion gene | ENST00000372582, ENST00000344799, ENST00000485671, | ENST00000487143, ENST00000355999, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 8=384 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IL1RAPL2 [Title/Abstract] AND STK39 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STK39 | GO:0018105 | peptidyl-serine phosphorylation | 24393035 |
Tgene | STK39 | GO:0018107 | peptidyl-threonine phosphorylation | 24393035 |
Tgene | STK39 | GO:0023014 | signal transduction by protein phosphorylation | 24393035 |
Tgene | STK39 | GO:0035556 | intracellular signal transduction | 24393035 |
Tgene | STK39 | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 24393035 |
Tgene | STK39 | GO:1901380 | negative regulation of potassium ion transmembrane transport | 24393035 |
Tgene | STK39 | GO:1905408 | negative regulation of creatine transmembrane transporter activity | 25531585 |
Tgene | STK39 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 25531585 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-7782-01A | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000372582 | ENST00000487143 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
5CDS-5UTR | ENST00000372582 | ENST00000355999 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
5CDS-5UTR | ENST00000344799 | ENST00000487143 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
5CDS-5UTR | ENST00000344799 | ENST00000355999 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
intron-5UTR | ENST00000485671 | ENST00000487143 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
intron-5UTR | ENST00000485671 | ENST00000355999 | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
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FusionProtFeatures for IL1RAPL2_STK39 |
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Hgene | Tgene |
IL1RAPL2 | STK39 |
May act as a mediator of stress-activated signals.Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTRactivities by the WNK scaffolds, probably through phosphorylation.{ECO:0000250|UniProtKB:Q9Z1W9}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL1RAPL2_STK39 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL1RAPL2_STK39 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IL1RAPL2 | EGFR | STK39 | SLC12A2, AATK, GSN, OTOF, WNK4, HSPH1, MAPK14, STK39, MBP, SPP1, API5, NOL3, NUBP1, PCNA, EHD1, FKBP9, XPNPEP1, TSC22D4, RELT, PSG1, RHOA, ATL2, ARX, MCM2, TSC22D2, CDC25B, RELL1, RELL2, LAMP2, ST8SIA4, KLRG2, PTGIR, TOMM22 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL1RAPL2_STK39 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL1RAPL2_STK39 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | STK39 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | STK39 | C0020538 | Hypertensive disease | 1 | CTD_human |