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Fusion gene ID: 17365 |
FusionGeneSummary for IL1RAPL1_IL1RAPL1 |
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Fusion gene information | Fusion gene name: IL1RAPL1_IL1RAPL1 | Fusion gene ID: 17365 | Hgene | Tgene | Gene symbol | IL1RAPL1 | IL1RAPL1 | Gene ID | 11141 | 11141 |
Gene name | interleukin 1 receptor accessory protein like 1 | interleukin 1 receptor accessory protein like 1 | |
Synonyms | IL-1-RAPL-1|IL-1RAPL-1|IL1R8|IL1RAPL|IL1RAPL-1|MRX10|MRX21|MRX34|OPHN4|TIGIRR-2 | IL-1-RAPL-1|IL-1RAPL-1|IL1R8|IL1RAPL|IL1RAPL-1|MRX10|MRX21|MRX34|OPHN4|TIGIRR-2 | |
Cytomap | Xp21.3-p21.2 | Xp21.3-p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-1 receptor accessory protein-like 1X-linked interleukin-1 receptor accessory protein-like 1interleukin 1 receptor-8mental retardation, X-linked 10oligophrenin-4three immunoglobulin domain-containing IL-1 receptor-related 2 | interleukin-1 receptor accessory protein-like 1X-linked interleukin-1 receptor accessory protein-like 1interleukin 1 receptor-8mental retardation, X-linked 10oligophrenin-4three immunoglobulin domain-containing IL-1 receptor-related 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NZN1 | Q9NZN1 | |
Ensembl transtripts involved in fusion gene | ENST00000378993, ENST00000302196, | ENST00000378993, ENST00000302196, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: IL1RAPL1 [Title/Abstract] AND IL1RAPL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IL1RAPL1 | GO:0045920 | negative regulation of exocytosis | 12783849 |
Tgene | IL1RAPL1 | GO:0045920 | negative regulation of exocytosis | 12783849 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB359358 | IL1RAPL1 | chrX | 29704923 | - | IL1RAPL1 | chrX | 29714986 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000378993 | ENST00000378993 | IL1RAPL1 | chrX | 29704923 | - | IL1RAPL1 | chrX | 29714986 | - |
intron-intron | ENST00000378993 | ENST00000302196 | IL1RAPL1 | chrX | 29704923 | - | IL1RAPL1 | chrX | 29714986 | - |
intron-intron | ENST00000302196 | ENST00000378993 | IL1RAPL1 | chrX | 29704923 | - | IL1RAPL1 | chrX | 29714986 | - |
intron-intron | ENST00000302196 | ENST00000302196 | IL1RAPL1 | chrX | 29704923 | - | IL1RAPL1 | chrX | 29714986 | - |
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FusionProtFeatures for IL1RAPL1_IL1RAPL1 |
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Hgene | Tgene |
IL1RAPL1 | IL1RAPL1 |
May regulate secretion and presynaptic differentiationthrough inhibition of the activity of N-type voltage-gated calciumchannel (PubMed:12783849). May activate the MAP kinase JNK(PubMed:15123616). Plays a role in neurite outgrowth (Bysimilarity). During dendritic spine formation can bidirectionallyinduce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).{ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824,ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}. | May regulate secretion and presynaptic differentiationthrough inhibition of the activity of N-type voltage-gated calciumchannel (PubMed:12783849). May activate the MAP kinase JNK(PubMed:15123616). Plays a role in neurite outgrowth (Bysimilarity). During dendritic spine formation can bidirectionallyinduce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).{ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824,ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL1RAPL1_IL1RAPL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL1RAPL1_IL1RAPL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL1RAPL1_IL1RAPL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL1RAPL1_IL1RAPL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IL1RAPL1 | C0004352 | Autistic Disorder | 2 | CTD_human;HPO |
Hgene | IL1RAPL1 | C0025202 | melanoma | 1 | CTD_human |
Hgene | IL1RAPL1 | C0809983 | Schizophrenia and related disorders | 1 | PSYGENET |
Hgene | IL1RAPL1 | C1136249 | Mental Retardation, X-Linked | 1 | CTD_human |
Hgene | IL1RAPL1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Tgene | IL1RAPL1 | C0004352 | Autistic Disorder | 2 | CTD_human;HPO |
Tgene | IL1RAPL1 | C0025202 | melanoma | 1 | CTD_human |
Tgene | IL1RAPL1 | C0809983 | Schizophrenia and related disorders | 1 | PSYGENET |
Tgene | IL1RAPL1 | C1136249 | Mental Retardation, X-Linked | 1 | CTD_human |
Tgene | IL1RAPL1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |