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Fusion gene ID: 17363 |
FusionGeneSummary for IL1R1_MAP4K4 |
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Fusion gene information | Fusion gene name: IL1R1_MAP4K4 | Fusion gene ID: 17363 | Hgene | Tgene | Gene symbol | IL1R1 | MAP4K4 | Gene ID | 3554 | 9448 |
Gene name | interleukin 1 receptor type 1 | mitogen-activated protein kinase kinase kinase kinase 4 | |
Synonyms | CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80 | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | |
Cytomap | 2q11.2-q12.1 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type I | mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase- | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P14778 | O95819 | |
Ensembl transtripts involved in fusion gene | ENST00000424272, ENST00000409929, ENST00000409589, ENST00000409329, ENST00000409288, ENST00000410023, ENST00000233946, | ENST00000425019, ENST00000324219, ENST00000350198, ENST00000302217, ENST00000413150, ENST00000347699, ENST00000456652, ENST00000350878, ENST00000498066, | |
Fusion gene scores | * DoF score | 3 X 6 X 5=90 | 10 X 9 X 6=540 |
# samples | 6 | 10 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IL1R1 [Title/Abstract] AND MAP4K4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IL1R1 | GO:0070498 | interleukin-1-mediated signaling pathway | 10383454 |
Hgene | IL1R1 | GO:0070555 | response to interleukin-1 | 10383454 |
Tgene | MAP4K4 | GO:0006468 | protein phosphorylation | 9890973 |
Tgene | MAP4K4 | GO:0035556 | intracellular signal transduction | 9890973 |
Tgene | MAP4K4 | GO:0046328 | regulation of JNK cascade | 14966141 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-CZ-4857-01A | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000424272 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000424272 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-intron | ENST00000424272 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409929 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-intron | ENST00000409929 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409589 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-intron | ENST00000409589 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-3CDS | ENST00000409329 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
5UTR-intron | ENST00000409329 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000409288 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-intron | ENST00000409288 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000410023 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-intron | ENST00000410023 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000425019 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000324219 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000350198 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000302217 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000413150 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000347699 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000456652 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-3CDS | ENST00000233946 | ENST00000350878 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
intron-intron | ENST00000233946 | ENST00000498066 | IL1R1 | chr2 | 102721332 | + | MAP4K4 | chr2 | 102499013 | + |
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FusionProtFeatures for IL1R1_MAP4K4 |
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Hgene | Tgene |
IL1R1 | MAP4K4 |
Receptor for IL1A, IL1B and IL1RN. After binding tointerleukin-1 associates with the coreceptor IL1RAP to form thehigh affinity interleukin-1 receptor complex which mediatesinterleukin-1-dependent activation of NF-kappa-B, MAPK and otherpathways. Signaling involves the recruitment of adapter moleculessuch as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIRdomains of the receptor/coreceptor subunits. Binds ligands withcomparable affinity and binding of antagonist IL1RN preventsassociation with IL1RAP to form a signaling complex. Involved inIL1B-mediated costimulation of IFNG production from T-helper 1(Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:10671496}. | Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IL1R1_MAP4K4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IL1R1_MAP4K4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IL1R1 | SIGIRR, IL1RAP, PIK3R1, TOLLIP, MYD88, IRAK2, IL1B, IL1RN, TOM1, IRAK4, IRAK1, TRAF6, MARCH8, PELI1, TICAM2, HERPUD1, ATP2A3, ICK, TUBB8, MFAP3, TNFRSF10B, BMPR1A | MAP4K4 | BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IL1R1_MAP4K4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | IL1R1 | P14778 | DB00026 | Anakinra | Interleukin-1 receptor type 1 | biotech | approved |
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RelatedDiseases for IL1R1_MAP4K4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IL1R1 | C0014175 | Endometriosis | 2 | CTD_human |
Hgene | IL1R1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | IL1R1 | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | IL1R1 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | IL1R1 | C0037274 | Dermatologic disorders | 1 | CTD_human |