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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17363

FusionGeneSummary for IL1R1_MAP4K4

check button Fusion gene summary
Fusion gene informationFusion gene name: IL1R1_MAP4K4
Fusion gene ID: 17363
HgeneTgene
Gene symbol

IL1R1

MAP4K4

Gene ID

3554

9448

Gene nameinterleukin 1 receptor type 1mitogen-activated protein kinase kinase kinase kinase 4
SynonymsCD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80FLH21957|HEL-S-31|HGK|MEKKK4|NIK
Cytomap

2q11.2-q12.1

2q11.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type Imitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-
Modification date2018051920180523
UniProtAcc

P14778

O95819

Ensembl transtripts involved in fusion geneENST00000424272, ENST00000409929, 
ENST00000409589, ENST00000409329, 
ENST00000409288, ENST00000410023, 
ENST00000233946, 
ENST00000425019, 
ENST00000324219, ENST00000350198, 
ENST00000302217, ENST00000413150, 
ENST00000347699, ENST00000456652, 
ENST00000350878, ENST00000498066, 
Fusion gene scores* DoF score3 X 6 X 5=9010 X 9 X 6=540
# samples 610
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL1R1 [Title/Abstract] AND MAP4K4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL1R1

GO:0070498

interleukin-1-mediated signaling pathway

10383454

HgeneIL1R1

GO:0070555

response to interleukin-1

10383454

TgeneMAP4K4

GO:0006468

protein phosphorylation

9890973

TgeneMAP4K4

GO:0035556

intracellular signal transduction

9890973

TgeneMAP4K4

GO:0046328

regulation of JNK cascade

14966141


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-CZ-4857-01AIL1R1chr2

102721332

+MAP4K4chr2

102499013

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000424272ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000424272ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-intronENST00000424272ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409929ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-intronENST00000409929ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409589ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-intronENST00000409589ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-3CDSENST00000409329ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
5UTR-intronENST00000409329ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000409288ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-intronENST00000409288ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000410023ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-intronENST00000410023ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000425019IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000324219IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000350198IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000302217IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000413150IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000347699IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000456652IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-3CDSENST00000233946ENST00000350878IL1R1chr2

102721332

+MAP4K4chr2

102499013

+
intron-intronENST00000233946ENST00000498066IL1R1chr2

102721332

+MAP4K4chr2

102499013

+

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FusionProtFeatures for IL1R1_MAP4K4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL1R1

P14778

MAP4K4

O95819

Receptor for IL1A, IL1B and IL1RN. After binding tointerleukin-1 associates with the coreceptor IL1RAP to form thehigh affinity interleukin-1 receptor complex which mediatesinterleukin-1-dependent activation of NF-kappa-B, MAPK and otherpathways. Signaling involves the recruitment of adapter moleculessuch as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIRdomains of the receptor/coreceptor subunits. Binds ligands withcomparable affinity and binding of antagonist IL1RN preventsassociation with IL1RAP to form a signaling complex. Involved inIL1B-mediated costimulation of IFNG production from T-helper 1(Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:10671496}. Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IL1R1_MAP4K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IL1R1_MAP4K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IL1R1SIGIRR, IL1RAP, PIK3R1, TOLLIP, MYD88, IRAK2, IL1B, IL1RN, TOM1, IRAK4, IRAK1, TRAF6, MARCH8, PELI1, TICAM2, HERPUD1, ATP2A3, ICK, TUBB8, MFAP3, TNFRSF10B, BMPR1AMAP4K4BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IL1R1_MAP4K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIL1R1P14778DB00026AnakinraInterleukin-1 receptor type 1biotechapproved

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RelatedDiseases for IL1R1_MAP4K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL1R1C0014175Endometriosis2CTD_human
HgeneIL1R1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneIL1R1C0020517Hypersensitivity1CTD_human
HgeneIL1R1C0032285Pneumonia1CTD_human
HgeneIL1R1C0037274Dermatologic disorders1CTD_human