FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17361

FusionGeneSummary for IL1R1_IL1R1

check button Fusion gene summary
Fusion gene informationFusion gene name: IL1R1_IL1R1
Fusion gene ID: 17361
HgeneTgene
Gene symbol

IL1R1

IL1R1

Gene ID

3554

3554

Gene nameinterleukin 1 receptor type 1interleukin 1 receptor type 1
SynonymsCD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80
Cytomap

2q11.2-q12.1

2q11.2-q12.1

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type Iinterleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type I
Modification date2018051920180519
UniProtAcc

P14778

P14778

Ensembl transtripts involved in fusion geneENST00000424272, ENST00000409929, 
ENST00000409589, ENST00000409329, 
ENST00000409288, ENST00000410023, 
ENST00000233946, 		ENST00000424272, 
ENST00000409929, ENST00000409589, 
ENST00000409329, ENST00000409288, 
ENST00000410023, ENST00000233946, 
Fusion gene scores* DoF score3 X 6 X 5=904 X 5 X 2=40
# samples 65
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IL1R1 [Title/Abstract] AND IL1R1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL1R1

GO:0070498

interleukin-1-mediated signaling pathway

10383454

HgeneIL1R1

GO:0070555

response to interleukin-1

10383454

TgeneIL1R1

GO:0070498

interleukin-1-mediated signaling pathway

10383454

TgeneIL1R1

GO:0070555

response to interleukin-1

10383454


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF054830IL1R1chr2

102783590

-IL1R1chr2

102784733

-
ChiTaRS3.1BE842588IL1R1chr2

102794956

-IL1R1chr2

102795017

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000424272ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409929ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409589ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409329ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000409288ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000410023ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000424272IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000409929IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000409589IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000409329IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000409288IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000410023IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000233946ENST00000233946IL1R1chr2

102783590

-IL1R1chr2

102784733

-
intron-intronENST00000424272ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000424272ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000424272ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000424272ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000424272ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000424272ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000424272ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409929ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409929ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409929ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409929ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409929ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409929ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409929ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000409589ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000409589ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000409589ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000409589ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000409589ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000409589ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000409589ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409329ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409329ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409329ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409329ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409329ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409329ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409329ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409288ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409288ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409288ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409288ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-intronENST00000409288ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409288ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
intron-3UTRENST00000409288ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000410023ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000410023ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000410023ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000410023ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000410023ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000410023ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000410023ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000233946ENST00000424272IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000233946ENST00000409929IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000233946ENST00000409589IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000233946ENST00000409329IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-intronENST00000233946ENST00000409288IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000233946ENST00000410023IL1R1chr2

102794956

-IL1R1chr2

102795017

+
3UTR-3UTRENST00000233946ENST00000233946IL1R1chr2

102794956

-IL1R1chr2

102795017

+

Top

FusionProtFeatures for IL1R1_IL1R1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL1R1

P14778

IL1R1

P14778

Receptor for IL1A, IL1B and IL1RN. After binding tointerleukin-1 associates with the coreceptor IL1RAP to form thehigh affinity interleukin-1 receptor complex which mediatesinterleukin-1-dependent activation of NF-kappa-B, MAPK and otherpathways. Signaling involves the recruitment of adapter moleculessuch as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIRdomains of the receptor/coreceptor subunits. Binds ligands withcomparable affinity and binding of antagonist IL1RN preventsassociation with IL1RAP to form a signaling complex. Involved inIL1B-mediated costimulation of IFNG production from T-helper 1(Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:10671496}. Receptor for IL1A, IL1B and IL1RN. After binding tointerleukin-1 associates with the coreceptor IL1RAP to form thehigh affinity interleukin-1 receptor complex which mediatesinterleukin-1-dependent activation of NF-kappa-B, MAPK and otherpathways. Signaling involves the recruitment of adapter moleculessuch as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIRdomains of the receptor/coreceptor subunits. Binds ligands withcomparable affinity and binding of antagonist IL1RN preventsassociation with IL1RAP to form a signaling complex. Involved inIL1B-mediated costimulation of IFNG production from T-helper 1(Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:10671496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IL1R1_IL1R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IL1R1_IL1R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IL1R1_IL1R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIL1R1P14778DB00026AnakinraInterleukin-1 receptor type 1biotechapproved
TgeneIL1R1P14778DB00026AnakinraInterleukin-1 receptor type 1biotechapproved

Top

RelatedDiseases for IL1R1_IL1R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL1R1C0014175Endometriosis2CTD_human
HgeneIL1R1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneIL1R1C0020517Hypersensitivity1CTD_human
HgeneIL1R1C0032285Pneumonia1CTD_human
HgeneIL1R1C0037274Dermatologic disorders1CTD_human
TgeneIL1R1C0014175Endometriosis2CTD_human
TgeneIL1R1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneIL1R1C0020517Hypersensitivity1CTD_human
TgeneIL1R1C0032285Pneumonia1CTD_human
TgeneIL1R1C0037274Dermatologic disorders1CTD_human