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Fusion gene ID: 1736 |
FusionGeneSummary for ANKIB1_LMTK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKIB1_LMTK2 | Fusion gene ID: 1736 | Hgene | Tgene | Gene symbol | ANKIB1 | LMTK2 | Gene ID | 54467 | 22853 |
| Gene name | ankyrin repeat and IBR domain containing 1 | lemur tyrosine kinase 2 | |
| Synonyms | - | AATYK2|BREK|KPI-2|KPI2|LMR2|PPP1R100|cprk|hBREK | |
| Cytomap | 7q21.2 | 7q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and IBR domain-containing protein 1 | serine/threonine-protein kinase LMTK2CDK5/p35-regulated kinaseapoptosis-associated tyrosine kinase 2brain-enriched kinasecyclin-dependent kinase 5/p35-regulated kinasekinase/phosphatase/inhibitor 2protein phosphatase 1, regulatory subunit 100serine | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9P2G1 | Q8IWU2 | |
| Ensembl transtripts involved in fusion gene | ENST00000265742, ENST00000486698, | ENST00000297293, ENST00000493372, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 3 X 3 X 2=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ANKIB1 [Title/Abstract] AND LMTK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LMTK2 | GO:0006468 | protein phosphorylation | 12393858 |
| Tgene | LMTK2 | GO:0018105 | peptidyl-serine phosphorylation | 16887929 |
| Tgene | LMTK2 | GO:0018107 | peptidyl-threonine phosphorylation | 16887929 |
| Tgene | LMTK2 | GO:0046777 | protein autophosphorylation | 12393858 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-56-8083-01A | ANKIB1 | chr7 | 91981956 | + | LMTK2 | chr7 | 97814363 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265742 | ENST00000297293 | ANKIB1 | chr7 | 91981956 | + | LMTK2 | chr7 | 97814363 | + |
| 5CDS-intron | ENST00000265742 | ENST00000493372 | ANKIB1 | chr7 | 91981956 | + | LMTK2 | chr7 | 97814363 | + |
| intron-3CDS | ENST00000486698 | ENST00000297293 | ANKIB1 | chr7 | 91981956 | + | LMTK2 | chr7 | 97814363 | + |
| intron-intron | ENST00000486698 | ENST00000493372 | ANKIB1 | chr7 | 91981956 | + | LMTK2 | chr7 | 97814363 | + |
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FusionProtFeatures for ANKIB1_LMTK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKIB1 | LMTK2 |
| Might act as an E3 ubiquitin-protein ligase, or as partof E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.{ECO:0000250}. | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 144_173 | 465 | 1090 | Repeat | Note=ANK 2 |
| Hgene | ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 45_74 | 465 | 1090 | Repeat | Note=ANK 1 |
| Hgene | ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 333_383 | 465 | 1090 | Zinc finger | RING-type 1%3B atypical |
| Tgene | >LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 1451_1454 | 263 | 1504 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 575_640 | 465 | 1090 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 851_870 | 465 | 1090 | Domain | UIM |
| Hgene | >ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 402_478 | 465 | 1090 | Zinc finger | Note=IBR-type%3B degenerate |
| Hgene | >ANKIB1 | chr7:91981956 | chr7:97814363 | ENST00000265742 | + | 9 | 20 | 519_548 | 465 | 1090 | Zinc finger | RING-type 2%3B degenerate |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 137_407 | 263 | 1504 | Domain | Protein kinase |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 143_151 | 263 | 1504 | Nucleotide binding | ATP |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 1_10 | 263 | 1504 | Topological domain | Cytoplasmic |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 32_42 | 263 | 1504 | Topological domain | Lumenal |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 64_1503 | 263 | 1504 | Topological domain | Cytoplasmic |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 11_31 | 263 | 1504 | Transmembrane | Helical |
| Tgene | LMTK2 | chr7:91981956 | chr7:97814363 | ENST00000297293 | + | 6 | 14 | 43_63 | 263 | 1504 | Transmembrane | Helical |
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FusionGeneSequence for ANKIB1_LMTK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANKIB1_ENST00000265742_chr7_91981956_+_LMTK2_ENST00000297293_chr7_97814363_+_1706aa MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPYQHNTPLHYAARHGMNKILGTFLGRDGNPNKRNVHNETSMHLLCMGP QIMISEGALHPRLARPTEDDFRRADCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDT PCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLL EAWMSNPENCCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVDMPCGHDFCRGCW ESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPL LRAPAVDCGKGHLFCCDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVT LWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNA LKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPG PGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQ SSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEP LCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVS TKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHS LDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSAL SSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPAT TGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAA QDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAY TNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGR HLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANKIB1_ENST00000265742_chr7_91981956_+_LMTK2_ENST00000297293_chr7_97814363_+_5118nt ATGGGAAATACAACCACCAAATTCCGTAAAGCACTCATCAATGGTGATGAAAACCTGGCCTGCCAAATATATGAAAACAATCCTCAGCTA AAAGAATCTCTTGATCCAAATACATCTTATGGGGAGCCCTACCAGCACAATACTCCATTACATTATGCTGCTAGACATGGAATGAATAAA ATATTAGGGACTTTTCTTGGTAGAGATGGAAATCCAAATAAACGGAATGTGCACAATGAAACATCTATGCATTTGTTGTGTATGGGACCT CAAATTATGATATCTGAAGGAGCCCTTCATCCTCGCTTGGCACGCCCCACAGAAGATGATTTCAGAAGAGCAGATTGTCTGCAGATGATC TTAAAATGGAAAGGAGCAAAACTTGACCAGGGTGAATATGAGAGAGCAGCTATTGATGCTGTTGATAACAAAAAAAACACACCCTTGCAC TATGCTGCTGCCTCAGGGATGAAAGCCTGTGTAGAGCTTTTAGTAAAACATGGAGGAGACTTGTTTGCTGAGAATGAAAATAAAGATACT CCTTGTGATTGTGCTGAAAAGCAACACCACAAAGATTTGGCCCTCAATCTGGAATCTCAAATGGTATTCTCACGGGATCCCGAGGCTGAA GAAATAGAAGCTGAATATGCTGCATTAGACAAACGAGAGCCATATGAAGGATTAAGGCCTCAGGATCTTCGTAGACTAAAAGATATGCTT ATTGTGGAAACTGCAGACATGCTTCAGGCTCCTCTCTTTACTGCTGAAGCTTTACTTCGAGCTCATGACTGGGACAGGGAGAAATTACTT GAAGCTTGGATGTCCAACCCGGAGAACTGCTGCCAACGATCAGGTGTTCAAATGCCAACTCCACCACCAAGTGGGTATAATGCCTGGGAC ACGCTCCCATCTCCAAGAACTCCAAGGACTACACGCTCTTCTGTCACCTCCCCAGATGAAATCAGCTTATCTCCTGGGGATTTAGACACC AGTTTGTGTGACATTTGTATGTGCAGTATCTCTGTATTTGAAGACCCTGTGGATATGCCCTGTGGACATGACTTTTGTAGAGGATGTTGG GAGTCGTTTTTGAATCTGAAAATTCAAGAAGGTGAAGCTCACAACATTTTTTGCCCTGCATATGATTGCTTCCAACTTGTACCTGTGGAT ATCATAGAAAGTGTAGTTTCAAAGGAGATGGACAAACGATACCTACAGTTTGATATTAAGGCCTTTGTTGAAAATAATCCTGCCATTAAA TGGTGTCCTACTCCAGGCTGTGACAGAGCAGTAAGACTAACGAAACAAGGGTCAAATACATCTGGATCTGATACACTCAGCTTCCCATTG CTGAGAGCTCCTGCTGTTGATTGTGGAAAAGGACACCTCTTCTGCTGTGATTTAGCCCTGCGGAATTGTTTTCTCACCTCCGACTTAAAT GTGAAAGTGGGAGATTACGGAATAGGATTCAGCAGGTACAAGGAGGATTATATTGAAACAGATGATAAAAAAGTTTTCCCTCTGCGATGG ACTGCTCCAGAATTAGTAACCAGCTTTCAAGACAGACTGCTAACTGCAGATCAGACTAAGTATAGTAATATCTGGTCTCTGGGTGTGACA CTTTGGGAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAACCAAGTCATTAGAGAGAGAGACACA AAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCTGATAGATGGTATGAAGTCTTACAGTTCTGTTGGCTGTCACCAGAAAAGAGACCC GCGGCTGAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTCGACTTTGAACAGCAGTGGAACGCT CTGAAGCCGAACACAAACAGCAGAGACTCCTCCAACAATGCTGCATTCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAA ATGGAGGAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCCGCTAAGCACGACCACTTTGACGAG CGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTACACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGG CCCGGAAAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCCCTGGAGTGGTTCCTGTTTTTGATGCCCACAACCTTTCTGTTGGA AGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGTAGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAAT CCAGAAAGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGAGCGTTGAACTTGAGGAGTCCAGTACAGATGAGGACTTCTTCCAA AGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGGGACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAACAATATATTTAATGAT GTGGACAAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTTCAAGCCGACTTTAAACCTGCCACT TTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTCATAACAGGCCACTTTGAGAAAGAAAAGCCCCGTAAGATTTTTGACAGTGAGCCT CTCTGCCTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCAGAAAACTTTTTATTTCTTCAAGAG AAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAACACATAAATGATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATG TTAGAAACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCTTGTCTTTGTTGCAGGAAAACGTAAGC ACAAAGGGTGACGATACAGATGTCATGCTCACAGGTGACACTTTGAGCACCTCATTGCAGTCTTCCCCGGAAGTGCAGGTACCTCCTACC TCCTTCGAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCACTCCCAACACAGGGAGAAACCCAGCCCACGTGTTTAGATGTTATT GTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCAGACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGC CTGGATAACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCCTGCGACTCACCGAAAGTGACTCTGTTCTTGCTGATGACATCCTT GCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAACTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGACCATCACAGTCATCGC CGGCTAGAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAAGAAGCAGGCTTGGTGTCTGCCCTC TCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAGGACAGCTTGTCAGCACCCTTCCCAGCCTCTGAGCCGTCCCTGGAAACCCCGGAC TCTCTGGAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAACTAGTGCCCCCCGATAAGCCGGCA GACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCCGAGTGGACCTTGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACC ACGGGCGATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGATGGTCACAGAGGCACAGAAGTGACC CCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATACCGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAG GAGGTCCCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGCAGCCCCTACCCGAGCCAGTCCTCCCCGAGCAAAGTCCTGCTGCC CAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCAGATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCC ACGCCGGAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCACGGAAGACGAGGCCAGCAGTCCCTGGAGTGTGCTGAATGCAGAA CTTAGCAGCGGCGATGACTTCGAGACACAGGACGATCGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAACGAACTCCTTGCCTAC ACCAATTCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGACATCGAAGGGAAGTACCTGGGGAAA CTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGACGGGATGGATGCAGACGAGGAGGACGAAAACAGCGACGACTCGGACGAGGACCTG CGGGCCTTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATCATCCTCAGCAACGAGGACGGAAGG CACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAATGCCCCCGACCCACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTT TTCGATGATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGAGGAGAGGCGTGCGGCCCGGACCTG AGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTGAGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAG TGGGATGATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAAGTAACCTGCTCAGCTCCAAGCCTTCTCTCCAAACATCCAAGTAC TTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAGAGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANKIB1_ENST00000265742_chr7_91981956_+_LMTK2_ENST00000297293_chr7_97814363_+_9635nt CGCAGCGGCCGGAGAGGGATGGGGGGCGCCCACCCAGTCTGAGCCTCGCCGCGGGCGCCTTCGGCTCACGCAGCGCTTCCCGCGGGCCGC CAGTGCGCACCCTCGGCCACATCAGCCTCCGCCTGGCGGGTGCACCCGGGCCGGCGAGGAAGGGGCAACCGTCCGGGTGGGTGGGGCGGG CTGGGTACCTGAGGTCACCAGCTCGGCTGTAGAGGCAGGGGCGGCGGAGGCGGAACTGCGGAGTTGCTGGGTCCACCGACCCTTACCCTC AGCGAGAGAAGTAACCAATGTGAAAGATGTTGCAGAAGTGTTCCAGAAGTGGCTGAAGATAGAAGGAAAAAAGTGCCACTGCCTATCAGA AAAAACAAAACAAAACATGGGAAATACAACCACCAAATTCCGTAAAGCACTCATCAATGGTGATGAAAACCTGGCCTGCCAAATATATGA AAACAATCCTCAGCTAAAAGAATCTCTTGATCCAAATACATCTTATGGGGAGCCCTACCAGCACAATACTCCATTACATTATGCTGCTAG ACATGGAATGAATAAAATATTAGGGACTTTTCTTGGTAGAGATGGAAATCCAAATAAACGGAATGTGCACAATGAAACATCTATGCATTT GTTGTGTATGGGACCTCAAATTATGATATCTGAAGGAGCCCTTCATCCTCGCTTGGCACGCCCCACAGAAGATGATTTCAGAAGAGCAGA TTGTCTGCAGATGATCTTAAAATGGAAAGGAGCAAAACTTGACCAGGGTGAATATGAGAGAGCAGCTATTGATGCTGTTGATAACAAAAA AAACACACCCTTGCACTATGCTGCTGCCTCAGGGATGAAAGCCTGTGTAGAGCTTTTAGTAAAACATGGAGGAGACTTGTTTGCTGAGAA TGAAAATAAAGATACTCCTTGTGATTGTGCTGAAAAGCAACACCACAAAGATTTGGCCCTCAATCTGGAATCTCAAATGGTATTCTCACG GGATCCCGAGGCTGAAGAAATAGAAGCTGAATATGCTGCATTAGACAAACGAGAGCCATATGAAGGATTAAGGCCTCAGGATCTTCGTAG ACTAAAAGATATGCTTATTGTGGAAACTGCAGACATGCTTCAGGCTCCTCTCTTTACTGCTGAAGCTTTACTTCGAGCTCATGACTGGGA CAGGGAGAAATTACTTGAAGCTTGGATGTCCAACCCGGAGAACTGCTGCCAACGATCAGGTGTTCAAATGCCAACTCCACCACCAAGTGG GTATAATGCCTGGGACACGCTCCCATCTCCAAGAACTCCAAGGACTACACGCTCTTCTGTCACCTCCCCAGATGAAATCAGCTTATCTCC TGGGGATTTAGACACCAGTTTGTGTGACATTTGTATGTGCAGTATCTCTGTATTTGAAGACCCTGTGGATATGCCCTGTGGACATGACTT TTGTAGAGGATGTTGGGAGTCGTTTTTGAATCTGAAAATTCAAGAAGGTGAAGCTCACAACATTTTTTGCCCTGCATATGATTGCTTCCA ACTTGTACCTGTGGATATCATAGAAAGTGTAGTTTCAAAGGAGATGGACAAACGATACCTACAGTTTGATATTAAGGCCTTTGTTGAAAA TAATCCTGCCATTAAATGGTGTCCTACTCCAGGCTGTGACAGAGCAGTAAGACTAACGAAACAAGGGTCAAATACATCTGGATCTGATAC ACTCAGCTTCCCATTGCTGAGAGCTCCTGCTGTTGATTGTGGAAAAGGACACCTCTTCTGCTGTGATTTAGCCCTGCGGAATTGTTTTCT CACCTCCGACTTAAATGTGAAAGTGGGAGATTACGGAATAGGATTCAGCAGGTACAAGGAGGATTATATTGAAACAGATGATAAAAAAGT TTTCCCTCTGCGATGGACTGCTCCAGAATTAGTAACCAGCTTTCAAGACAGACTGCTAACTGCAGATCAGACTAAGTATAGTAATATCTG GTCTCTGGGTGTGACACTTTGGGAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAACCAAGTCAT TAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCTGATAGATGGTATGAAGTCTTACAGTTCTGTTGGCTGTC ACCAGAAAAGAGACCCGCGGCTGAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTCGACTTTGA ACAGCAGTGGAACGCTCTGAAGCCGAACACAAACAGCAGAGACTCCTCCAACAATGCTGCATTCCCAATTCTCGACCACTTTGCCAGGGA CCGGCTGGGTCGTGAAATGGAGGAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCCGCTAAGCA CGACCACTTTGACGAGCGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTACACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTC GCTTTCAGATCCTGGGCCCGGAAAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCCCTGGAGTGGTTCCTGTTTTTGATGCCCA CAACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGTAGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCAC AACCGACATGGATAATCCAGAAAGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGAGCGTTGAACTTGAGGAGTCCAGTACAGA TGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGGGACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAA CAATATATTTAATGATGTGGACAAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTTCAAGCCGA CTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTCATAACAGGCCACTTTGAGAAAGAAAAGCCCCGTAAGAT TTTTGACAGTGAGCCTCTCTGCCTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCAGAAAACTT TTTATTTCTTCAAGAGAAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAACACATAAATGATCTTCAGACAGAACTTAAGAATGCTGG TTTTACTGAAGCTATGTTAGAAACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCTTGTCTTTGTT GCAGGAAAACGTAAGCACAAAGGGTGACGATACAGATGTCATGCTCACAGGTGACACTTTGAGCACCTCATTGCAGTCTTCCCCGGAAGT GCAGGTACCTCCTACCTCCTTCGAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCACTCCCAACACAGGGAGAAACCCAGCCCAC GTGTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCAGACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGA TGCCAGAACCCACAGCCTGGATAACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCCTGCGACTCACCGAAAGTGACTCTGTTCT TGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAACTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGA CCATCACAGTCATCGCCGGCTAGAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAAGAAGCAGG CTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAGGACAGCTTGTCAGCACCCTTCCCAGCCTCTGAGCCGTC CCTGGAAACCCCGGACTCTCTGGAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAACTAGTGCC CCCCGATAAGCCGGCAGACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCCGAGTGGACCTTGCATCCCGCTCCCGAGGGCACCGCAGA CTCAGAACCAGCCACCACGGGCGATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGATGGTCACAG AGGCACAGAAGTGACCCCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATACCGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCC CGAGAAAAGGTCTGAGGAGGTCCCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGCAGCCCCTACCCGAGCCAGTCCTCCCCGA GCAAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCAGATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGA CCTGGAATTAAGAGCCACGCCGGAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCACGGAAGACGAGGCCAGCAGTCCCTGGAG TGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGATCGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAA CGAACTCCTTGCCTACACCAATTCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGACATCGAAGG GAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGACGGGATGGATGCAGACGAGGAGGACGAAAACAGCGACGA CTCGGACGAGGACCTGCGGGCCTTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATCATCCTCAG CAACGAGGACGGAAGGCACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAATGCCCCCGACCCACTGCCCGAGGACTGGAAGAAGGAAAA GAAGGCAGTCACGTTTTTCGATGATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGAGGAGAGGC GTGCGGCCCGGACCTGAGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTGAGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGA AGGTGGTGGCTTTGAGTGGGATGATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAAGTAACCTGCTCAGCTCCAAGCCTTCTCT CCAAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAGAGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCAT CTCTCCCGCCAACATTGCCAGCTTTTCCCTCACACACCTGACCGACTCGGACATCGAGCAGGGCGGAAGCAGCGAAGACGGAGAAAAGGA CTAGGTGGCTGCCAACGCGCACGCTCGGGTCCGAGGCTGCTCCCCTGGAGCGGCGCCCCTGCGCCCTCAGCCCGAGCAGCGACATCCACT CGCCATTTGCTGACATGAGATTGGGAGGAAGAATCCAGAGGTGAAGAGGGAGACGGCTCTTAGCTGCGTTCAAGGCGGGGCCCTCGGGAG CCCAGGTGCAGAGCGAGGCCGTGTCCAGGAGCCGGCGTCCCTCAGTGCCCCGTGCACCCGCGGCCGCGGCCTCCCAGGCAGTGCTCATGC GCTGGCCGTCGGGGGAGGCAGGGGCACAGCCTCCATGTGCGCGCGCGTGTGGAGCTGTGTGCACCGCATGTGTGCTTTCCACAGGGGCGT CTCTGCGTCCACGCCTGCACATCCCGGCGCACGTGTGGGCACCACAGAGGACACGTGAGGGGAATGGTCACCAGTGAGCCATATTTATTA TTTCTAGAGAAATCACGAACTGCTTTCTGTAATTGCACTGTGGATAAATGTTCCGAGAGTCTCCATTGTTGTACAGGATCTTCAGTTATT CGAGGGGAATGAGGCAGGTCAAGCCGATGCTAGCCACTAGTTTGATTTTTTTTCTGTTTTATAGTTTGCGCTGCATGGTACTTGTGAAGC TTAAATATTTTGAGTGTTCTACTGTGTCTAGGATTGTTGGGATTGTACATATGGTACTCTTTCATAAATGATAAATGATTCTGAATGTTA GTGTTTTATGTTCATATAGGAAATATTTTCATTGAGTCCAAAATACCACTGTTTTGTTGATGGACTTGAATGCATTTTTGTCTCTTCTTG ATGAAGCGGCTTTGCCGCAGCAAATGAGGCTTCTCTCTGAGGAGCTGAGAGGTCTTGCAGCCTCTCCTTGTCATTCTCCCACCCCACATC CCATTTTTTAAAGCCCTTTTGGTAAAAACCAACAGGTTGTGGCCGCAGACCTCAGATGGACCCGGCCCATCCCTGGGGACGTGCTGGCGT GGCAGGTCCAGAGAGCTGCACCCTGCACGGGGCACCGCACCGCTTCCCTCCGCGCAGCTCTTCTGCCTGGTTTTCGGAGGCCAGGCTGCT GGGAAGCTTCCGTGTTCCTGTCAGTCCTTCCTTCAAGAAGCCGGGGAACTCAGGCAGACTCATCTCCGCAGAGCATACCAGCCGTGGGGG ACCGTTCGACTTGATGATGTGTGCACACTTCAGGTGGTGGGGACTTGAGCTTTAAAAAAACCTCCACAGCCGAATCTTCTCCTCCGAGCC ACTCCACGTCACGTCCAGCTGGGCCTGGCCAGTCTGTGGTTATCCATGTGGGATGAGATAACACCACATCCTGCAGCTGTGAAGGGGGAT GGACAAGGGACGACGGCCGACGGCAGAGCATCAGCAGCCGACACATAGTTCGGGTCGGGGCCTTGGGTGGTCCTGCATGGCCCGGGACTC ATCTCACGGACCCTCCGTTCTGCATTAAGCCCCAGGTTCTCTTCTGGCTTTGAAAGGGCCCGAGTGCTCCCAGTGTAGCTTCGTCACATC GTCACGAGCCCCTGTGGTCATGGGCGACCTCACACCTCCCTCCCTGAGTTCTGCTCTGACATAAGGAAGTCCTCGGTGGCTGGTGCAGCG CGGCTGTGCTGTGCTGGGGAGGCAGCCGTTCCTTCGGGGGTCCTTGGGCCTGCAGTCCCCTCATACTCACCCTTCACCCAACATATTTTC CGGTGCTGATATGTTTCCAGACTCCAGCGCAACCTGGGGTGCTCTCCAGACCCGTGCAGGGGCCGCCTGGGGTACACGGAAGGAAGTTGA GTCCTAGTGCAAAATGCAGGCGGACGTTGCCAGAGAGTGCGCAGCAAATGACCTTCATTGCCAGTTCCACCCTACTCCTCTCATTTTTTA TACTAAGCAATAACTTTCCAAAGCAAGAAGTTCAGGATGGAGAGAGTCCCCTCCTGTGTAGGCATGGGGTGGATGCGGTGCCCACCTGGG CTATGTGGGGAGCACCACTGTCTCGGGATGCGCGAATTTTTTTTTTTTTTTTAATTAACAGGGCATTAGAAGATGATTTTGCCAAAATTG TCATGACTCTGAATTCTTGCTGTGGGGACTTCCTGAGTTTTCTCAGTTTTTACATCTAAGATTAGTCTTGGCTGAAGAGAAATGAGACGT GATTATACTACTTTTTCAATTGCAGGTTTAAGGAGTTCAGATTTAATGACCAAAGTCATACAGATCATGGAATCTGTCGTCGTCTTATAC AGTGTCAGCCTCGAGTACATTTATTAACCTTTTGGGGCTGTCAGTTTTCCACTAGGATTAAGATTTTGGCCGGGCGCGGTGGCTCACGCC TGCAATCCCAACACATTGGGGGGTCGAGGCGGACGGATCACTTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCTCG TCTCTACTAAAAATACAAAATATATATATATATATATATACTAGCTGGGGCACATAGTGGTGTGCACCTGTAGTCCCAGCTGCTTGGGAG GCTGAGGTGGGAGGATGGCTAGAGCCCAGGAGATGGGTGTTGCAGTGAGCTGAGACCATGCCACTGTACTCTAGCCTGGGTAACAGCCAG ACCCTGTCTCAAAAAAAAAAACAATTTTTTTCATAACATAATTCCCATTTTTATTTATTTTGAGTCACTCATAATTAATTGCCAAAAAAG CATTTTATACATTGAGTTGGGGGGTAGTGGATCTTAGTGTGGTGTTGCATGGAGGGGCGAGATTTTATATTTATAATCAACACGTGGGTT AACATGTTTTTTTGAAATCCAAGCAATACACAGGAAATTTAAGTAGAATAAAAATTGCAGCCCATTTTTGAAATGTCAGCATGTGCTGTG TTCAGTTCAGGTTTTTGTTGTTTGTTTTGTTATTTTTTAACTAATAAGTTGGTTATCAGTGGTGGGTTTTCAAAATGTACTTGTTCTAAT AAGTTGTACAATGAACTAAATCAGTGGCATTCTCTAGATAATGTGGGGGAAGGTTAGAATATTTTCTGGCCTTCTATGGGGTAGCAACCC AGAATCAATCTGAATTAGTCCTGTTTTGGTGGAGTTTGTACATTTTAAATCCTATAACAAAAATAATCTAGTTTTCATTTCCTTACTAGC TAGATGCGAATTTGTCTTTTTGAATGACCCTGTCAATAAGCCAGAAAGGGCAACCCAGAAAAAGTGCTCCCCACATCCTTCTGAGACTTG GCCTGTGTGTGTGGACGAGAAGCCATTCACCGTAAGGGTGCAGAAAGCTCGACCAAGCCGAATTGCAAACAACGTTCGTTCTATTTTTAA ATGTACAGGTTCGATCGTTTCTATAGAAATGGGTTTATCTAAGAAAAGTCTTGGTTTGTCTTGCTGCTGTAAAAGGCCTTTCCAAACCCC TCCTTTTATTCCTGTTTCCCGAAATAAGGTATTTGTAGAGTTAAGGACCTACTGCATGCCTGTCCCCAGGGCCCCGGTGGAAGGAAGGCA GCGCCTGCTCTTCCTTAACTCAGCCCATCATCTGAAAATTCAGAAGTGAACCAAGGGTTAGACGCCAGAGGTTGGGCTTCTGTTAGAGTG GCTTCAAAACATGAGCCTTATGGGAAGTAGCCTTAAAAAAAGAATGGGTATACGCAGTGACTTCCGATGGAAATCTCCAAAACAATATTC CTAAGTAGCAATGGGGTTGGCTCAAGTCTTTATTAACAAAGAACATTCTCTTTCATCTATAAAGAAATTCTTAAAGATGCATTGACAGTG TTGAATTACCAACAGCCTGTGAAGATCAGTTTGACCGGTGTGGACACGTGCTGGTTAAGCACTCAGGCCTACGTGGGCCGAGCGGGATCT TGATCATGGGGCTGGTGTATGGATCCACCGTCGGATTCCGTCTGCAGAGGAGGACGTAGGGGGCCGTCACACCCACCAGGCCTCCCTGCT GTGCTTTAACACAGGCAGAAGAGGTTCATGGCAATATAATAGTCAATGAACTTTCAGTTTAAATTGTGTACATTTTTAAATTGTAAGATT TTTACTGTATATTGATGCATAGTGTGATTCAATAAATTGCTTGTAATTTAAAAACTATTTAATATTCAAAATAAATATAGTTATATATTT |
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FusionGenePPI for ANKIB1_LMTK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANKIB1 | UBC, KPNA2, NR4A1, CEP250 | LMTK2 | CDK5, PPP1R2, LMTK2, PPP1CA, MYO6, PPP1CC, PPP1R3A, SORT1, PTPRM, SLC34A2, PPP1CB, PPP3CB, PPM1A, PPM1F, PPM1K, ILKAP, PTPRR, PTPN6, PTPN12, DUSP6, DUSP14, DUSP19, DUPD1, STYX, CDC14A, PTPDC1, TPTE2, MTMR6, CDC25C, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANKIB1_LMTK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKIB1_LMTK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LMTK2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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