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Fusion gene ID: 17332 |
FusionGeneSummary for IKZF2_MICU2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IKZF2_MICU2 | Fusion gene ID: 17332 | Hgene | Tgene | Gene symbol | IKZF2 | MICU2 | Gene ID | 22807 | 221154 |
| Gene name | IKAROS family zinc finger 2 | mitochondrial calcium uptake 2 | |
| Synonyms | ANF1A2|HELIOS|ZNF1A2|ZNFN1A2 | 1110008L20Rik|EFHA1 | |
| Cytomap | 2q34 | 13q12.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein Heliosikaros family zinc finger protein 2zinc finger DNA binding protein Helioszinc finger protein, subfamily 1A, 2 (Helios) | calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UKS7 | Q8IYU8 | |
| Ensembl transtripts involved in fusion gene | ENST00000457361, ENST00000342002, ENST00000434687, ENST00000374319, ENST00000374327, ENST00000451136, ENST00000413091, ENST00000421754, ENST00000442445, | ENST00000382374, ENST00000479790, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IKZF2 [Title/Abstract] AND MICU2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MICU2 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 24560927 |
| Tgene | MICU2 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration | 24560927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-5512-01A | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000457361 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000457361 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000342002 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000342002 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000434687 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000434687 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000374319 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000374319 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| intron-3CDS | ENST00000374327 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| intron-5UTR | ENST00000374327 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000451136 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000451136 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000413091 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000413091 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| In-frame | ENST00000421754 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| 5CDS-5UTR | ENST00000421754 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| intron-3CDS | ENST00000442445 | ENST00000382374 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
| intron-5UTR | ENST00000442445 | ENST00000479790 | IKZF2 | chr2 | 213914437 | - | MICU2 | chr13 | 22069457 | - |
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FusionProtFeatures for IKZF2_MICU2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IKZF2 | MICU2 |
| Key regulator of mitochondrial calcium uniporter (MCU)required to limit calcium uptake by MCU when cytoplasmic calciumis low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1and MICU2 form a disulfide-linked heterodimer that stimulate andinhibit MCU activity, depending on the concentration of calcium(PubMed:24560927). MICU2 acts as a gatekeeper of MCU that sensescalcium level via its EF-hand domains: prevents channel opening atresting calcium, avoiding energy dissipation and cell-deathtriggering (PubMed:24560927). {ECO:0000269|PubMed:24503055,ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864,ECO:0000269|PubMed:26903221}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 112_134 | 165 | 501 | Zinc finger | C2H2-type 1 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 140_162 | 165 | 501 | Zinc finger | C2H2-type 2 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 112_134 | 191 | 527 | Zinc finger | C2H2-type 1 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 140_162 | 191 | 527 | Zinc finger | C2H2-type 2 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 168_190 | 191 | 527 | Zinc finger | C2H2-type 3 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 112_134 | 191 | 527 | Zinc finger | C2H2-type 1 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 140_162 | 191 | 527 | Zinc finger | C2H2-type 2 |
| Hgene | IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 168_190 | 191 | 527 | Zinc finger | C2H2-type 3 |
| Tgene | >MICU2 | chr2:213914437 | chr13:22069457 | ENST00000382374 | - | 9 | 12 | 362_397 | 347 | 435 | Domain | EF-hand 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 168_190 | 165 | 501 | Zinc finger | C2H2-type 3 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 196_219 | 165 | 501 | Zinc finger | C2H2-type 4 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 471_493 | 165 | 501 | Zinc finger | C2H2-type 5 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000374319 | - | 6 | 9 | 499_523 | 165 | 501 | Zinc finger | C2H2-type 6 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 196_219 | 191 | 527 | Zinc finger | C2H2-type 4 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 471_493 | 191 | 527 | Zinc finger | C2H2-type 5 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000434687 | - | 6 | 9 | 499_523 | 191 | 527 | Zinc finger | C2H2-type 6 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 196_219 | 191 | 527 | Zinc finger | C2H2-type 4 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 471_493 | 191 | 527 | Zinc finger | C2H2-type 5 |
| Hgene | >IKZF2 | chr2:213914437 | chr13:22069457 | ENST00000457361 | - | 5 | 8 | 499_523 | 191 | 527 | Zinc finger | C2H2-type 6 |
| Tgene | MICU2 | chr2:213914437 | chr13:22069457 | ENST00000382374 | - | 9 | 12 | 2_50 | 347 | 435 | Compositional bias | Note=Ala-rich |
| Tgene | MICU2 | chr2:213914437 | chr13:22069457 | ENST00000382374 | - | 9 | 12 | 172_207 | 347 | 435 | Domain | EF-hand 1 |
| Tgene | MICU2 | chr2:213914437 | chr13:22069457 | ENST00000382374 | - | 9 | 12 | 227_262 | 347 | 435 | Domain | EF-hand 2 |
| Tgene | MICU2 | chr2:213914437 | chr13:22069457 | ENST00000382374 | - | 9 | 12 | 293_328 | 347 | 435 | Domain | EF-hand 3 |
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FusionGeneSequence for IKZF2_MICU2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IKZF2_ENST00000457361_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_279aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRR DALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVW >In-frame_IKZF2_ENST00000342002_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_285aa MHCTLTMETEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPL IESSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCS YACRRRDALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIK >In-frame_IKZF2_ENST00000434687_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_279aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRR DALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVW >In-frame_IKZF2_ENST00000374319_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_253aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQEL >In-frame_IKZF2_ENST00000451136_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_253aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQEL >In-frame_IKZF2_ENST00000413091_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_279aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRR DALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVW >In-frame_IKZF2_ENST00000421754_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_253aa METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV ADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQEL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IKZF2_ENST00000457361_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_837nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTT TGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACT CAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGG GACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATT TTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCAT CGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGG >In-frame_IKZF2_ENST00000342002_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_855nt ATGCATTGCACTTTGACTATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAAT ATGGCAATTGACCTCACCTCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATG CAGAGTGATGAAGAGTGTGACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTA ATTGAGAGCAGCGAGGTGGCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGT GACGTCTGTGGCATGGTTTGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAG TGTGGAGCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGC TACGCCTGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAA GAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTG TTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAA >In-frame_IKZF2_ENST00000434687_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_837nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTT TGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACT CAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGG GACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATT TTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCAT CGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGG >In-frame_IKZF2_ENST00000374319_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_759nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA >In-frame_IKZF2_ENST00000451136_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_759nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA >In-frame_IKZF2_ENST00000413091_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_837nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTT TGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACT CAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGG GACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATT TTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCAT CGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGG >In-frame_IKZF2_ENST00000421754_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_759nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IKZF2_ENST00000457361_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1555nt GGGCTTGGCTTGGAGGGGGCAAGGGAGGGAAAGAGAGAAGGGGGAAACACAAAAAACTTCTTTCTTTCTCCCTCCGTTTATCTTCAGCCC GACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGCATTGCACTTTGACTATGGAAACAGA GGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACC CAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACC CCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAG GAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCC CAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAA CCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCAC AGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGT CTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATG GGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGG AAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTAT TTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGT AGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAA CTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGAC CAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTT ATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAATGTTCTATCTGG >In-frame_IKZF2_ENST00000342002_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1555nt GGGCTTGGCTTGGAGGGGGCAAGGGAGGGAAAGAGAGAAGGGGGAAACACAAAAAACTTCTTTCTTTCTCCCTCCGTTTATCTTCAGCCC GACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGCATTGCACTTTGACTATGGAAACAGA GGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACC CAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACC CCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAG GAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCC CAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAA CCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCAC AGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGT CTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATG GGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGG AAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTAT TTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGT AGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAA CTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGAC CAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTT ATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAATGTTCTATCTGG >In-frame_IKZF2_ENST00000434687_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1696nt GCTCCTCGCTGAAGATGGAGGAAGTAAAAACAGGATTACCCTTAGCTACAGATCCACTGCCTTAGTTTCCACCACCAACTGCAGTGCACA AACACACGTTAGGCACAGGAAAGAAAGAAAGACAGAGGACACATTAACAGTAAACACAAACAAAAGGGTGATGGGATTATTTTACTGCAT GCACTGCTGAGCCCGACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGGTGATGAATCTT TTTTAATCAAAGGACAATTTCTTTTCATTGCACTTTGACTATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTC ACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCAC AAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGG TAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCT TCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGA ACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCC GTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGC TGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAG TCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTG TGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAA TTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATA AGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTG TCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGAT ATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAA TAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCT >In-frame_IKZF2_ENST00000374319_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1618nt GCTCCTCGCTGAAGATGGAGGAAGTAAAAACAGGATTACCCTTAGCTACAGATCCACTGCCTTAGTTTCCACCACCAACTGCAGTGCACA AACACACGTTAGGCACAGGAAAGAAAGAAAGACAGAGGACACATTAACAGTAAACACAAACAAAAGGGTGATGGGATTATTTTACTGCAT GCACTGCTGAGCCCGACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGGTGATGAATCTT TTTTAATCAAAGGACAATTTCTTTTCATTGCACTTTGACTATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTC ACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCAC AAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGG TAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCT TCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTC TGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGA GTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGA TGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGA ATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATA ATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATT CTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGA TATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACA CTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCT TCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTT >In-frame_IKZF2_ENST00000451136_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1308nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA AAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGT GATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTC ATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTT TTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATAC ATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTT CAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACAT >In-frame_IKZF2_ENST00000413091_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1386nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTT TGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACT CAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGG GACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATT TTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCAT CGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGG AAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAA GTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTA AAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGT AAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAA GTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTC ATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAAT >In-frame_IKZF2_ENST00000421754_chr2_213914437_-_MICU2_ENST00000382374_chr13_22069457_-_1308nt ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA AAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGT GATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTC ATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTT TTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATAC ATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTT CAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACAT |
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FusionGenePPI for IKZF2_MICU2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IKZF2 | HDAC4, SIN3A, SIN3B, CHD4, HDAC2, HDAC5, IKZF1, IKZF3, IKZF2, NOTCH1, HDAC1, CTBP1, AQP1, CTBP2, LONRF1, NFATC1, NFATC2, IKZF5 | MICU2 | COPS5, SPACA1, ASH2L, MICU1, ACOX3, CSNK1E, CSNK1D, GAPVD1, SMAP1, KIAA1217, TBC1D22A, KLHL22, CPLX4, CDH5, TRIM44, PON1, RANBP6, DCAF11, ARMC6, ATG7, BPNT1, SLC1A1, SLC39A12, TUBB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IKZF2_MICU2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IKZF2_MICU2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IKZF2 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Hgene | IKZF2 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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