FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17329

FusionGeneSummary for IKZF1_PHF14

check button Fusion gene summary
Fusion gene informationFusion gene name: IKZF1_PHF14
Fusion gene ID: 17329
HgeneTgene
Gene symbol

IKZF1

PHF14

Gene ID

10320

9678

Gene nameIKAROS family zinc finger 1PHD finger protein 14
SynonymsCVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1-
Cytomap

7p12.2

7p21.3

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)PHD finger protein 14
Modification date2018052720180519
UniProtAcc

Q13422

O94880

Ensembl transtripts involved in fusion geneENST00000440768, ENST00000359197, 
ENST00000343574, ENST00000331340, 
ENST00000349824, ENST00000357364, 
ENST00000346667, ENST00000438033, 
ENST00000439701, ENST00000413698, 
ENST00000492782, 
ENST00000403050, 
ENST00000445996, ENST00000469407, 
Fusion gene scores* DoF score5 X 4 X 3=607 X 5 X 6=210
# samples 67
** MAII scorelog2(6/60*10)=0log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKZF1 [Title/Abstract] AND PHF14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-3917-01AIKZF1chr7

50367353

+PHF14chr7

11150977

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000440768ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000440768ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000440768ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000359197ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000359197ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000359197ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000343574ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000343574ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000343574ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000331340ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000331340ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000331340ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000349824ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000349824ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000349824ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000357364ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000357364ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000357364ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000346667ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000346667ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000346667ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000438033ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000438033ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000438033ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000439701ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000439701ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000439701ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000413698ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-intronENST00000413698ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
5CDS-3UTRENST00000413698ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+
3UTR-intronENST00000492782ENST00000403050IKZF1chr7

50367353

+PHF14chr7

11150977

+
3UTR-intronENST00000492782ENST00000445996IKZF1chr7

50367353

+PHF14chr7

11150977

+
3UTR-3UTRENST00000492782ENST00000469407IKZF1chr7

50367353

+PHF14chr7

11150977

+

Top

FusionProtFeatures for IKZF1_PHF14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF1

Q13422

PHF14

O94880

Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for IKZF1_PHF14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IKZF1_PHF14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IKZF1UBE2I, AP2M1, CTBP1, RBBP8, SIN3A, NCOR2, TBP, GTF2B, SIN3B, HDAC1, CHD4, HDAC2, HDAC4, HDAC5, HDAC7, HDAC3, IKZF4, IKZF5, IKZF2, GATA1, SMARCE1, NUDT21, CSNK1G1, CDK2AP2, IKZF3, RBBP4, CHD3, SMARCA4, NOTCH1, HDAC11, TDG, CRBN, ANKRD11, PRKAB2, BYSL, CKS1B, CTBP2, DCX, DDX6, FGF12, PIN1, PSMA1, PSMA4, RAD51D, SDCBP, SNRPF, DYRK2, AP1M1, MTA1, WTAP, MORF4L2, RWDD2B, IKZF1, MCRS1, MAD2L2, GLRX3, NEK6, MORF4L1, PNKP, SNW1, ISCU, LSM4, FAM50B, ZNF581, SYT17, C1orf109, C19orf66, LMO3, CBX8, SH2D4A, KIF9, GMCL1P1, AEN, C8orf33, SCNM1, NOC4L, ARMC7, FAM214B, FAM161A, SPATC1L, FRMD6, ZNF417, ZMAT2, ALKBH3, CEP57L1, C1orf174, FAM74A4, SH3BP2, MPPED2, NFATC2, NFATC1, MIB2, KLHDC10, POC1A, FOXK2, FOXK1, WDR76, APPBP2, ANKRD27, ZMYND19, KLHDC3, NFS1, MTA3, CUL2, BTBD1, HSD17B4, WDR26, GATAD2A, MKLN1, GATAD2B, RMND5A, RANBP10, MTA2, ARMC8, GALC, POTEIPHF14H2AFY, PCBD2, MOV10, HIST1H2BA, IFI16, DAXX, HDAC1, HNRNPU, TCF20, KAT6A, CDK2AP1, TM9SF4, HMG20A, NLRP3, CEP170P1, H2AFX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IKZF1_PHF14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for IKZF1_PHF14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIKZF1C0009324Ulcerative Colitis1CTD_human
HgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
HgeneIKZF1C0024299Lymphoma1CTD_human
HgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT