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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1729

FusionGeneSummary for ANKH_STEAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKH_STEAP3
Fusion gene ID: 1729
HgeneTgene
Gene symbol

ANKH

STEAP3

Gene ID

56172

55240

Gene nameANKH inorganic pyrophosphate transport regulatorSTEAP3 metalloreductase
SynonymsANK|CCAL2|CMDJ|CPPDD|HANK|MANK|SLC62A1AHMIO2|STMP3|TSAP6|dudlin-2|dudulin-2|pHyde
Cytomap

5p15.2

2q14.2

Type of geneprotein-codingprotein-coding
Descriptionprogressive ankylosis protein homologankylosis, progressive homologmetalloreductase STEAP3STEAP family member 3, metalloreductasesix-transmembrane epithelial antigen of prostate 3tumor suppressor pHydetumor suppressor-activated pathway protein 6
Modification date2018051920180523
UniProtAcc

Q9HCJ1

Q658P3

Ensembl transtripts involved in fusion geneENST00000284268, ENST00000535119, 
ENST00000503939, 		ENST00000450943, 
ENST00000354888, ENST00000393108, 
ENST00000393110, ENST00000393106, 
ENST00000393107, ENST00000409811, 
ENST00000425223, 
Fusion gene scores* DoF score7 X 4 X 4=1123 X 3 X 3=27
# samples 73
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKH [Title/Abstract] AND STEAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTEAP3

GO:0009306

protein secretion

15319436


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01AANKHchr5

14871461

-STEAP3chr2

120003065

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284268ENST00000450943ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000354888ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000393108ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000393110ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000393106ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000393107ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000409811ANKHchr5

14871461

-STEAP3chr2

120003065

+
5CDS-5UTRENST00000284268ENST00000425223ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000450943ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000354888ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000393108ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000393110ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000393106ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000393107ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000409811ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000535119ENST00000425223ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000450943ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000354888ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000393108ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000393110ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000393106ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000393107ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000409811ANKHchr5

14871461

-STEAP3chr2

120003065

+
intron-5UTRENST00000503939ENST00000425223ANKHchr5

14871461

-STEAP3chr2

120003065

+

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FusionProtFeatures for ANKH_STEAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKH

Q9HCJ1

STEAP3

Q658P3

Regulates intra- and extracellular levels of inorganicpyrophosphate (PPi), probably functioning as PPi transporter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKH_STEAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKH_STEAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKHAPOE, RPSA, TRIM25STEAP3BNIP3L, PKMYT1, BAD, SETD7, BSG, TEX29, NT5E, SLC39A4, DLK1, TMEFF1, ENPP6, FAM177A1, TMEM17, TMEM216, CDH1, ASPH, RANBP6, DPEP1, ATP2B2, MRAP2, SCN3B, MBLAC2, TIGD5, CD83, PTGIR, TTC21A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKH_STEAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKH_STEAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKHC0856830Calcium pyrophosphate arthropathy3CTD_human;ORPHANET;UNIPROT
HgeneANKHC0014175Endometriosis1CTD_human
HgeneANKHC0040427Tooth Abnormalities1CTD_human
HgeneANKHC0376634Craniofacial Abnormalities1CTD_human
HgeneANKHC1852502CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT1CTD_human;UNIPROT