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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17230

FusionGeneSummary for IGHG1_GOLGA8A

check button Fusion gene summary
Fusion gene informationFusion gene name: IGHG1_GOLGA8A
Fusion gene ID: 17230
HgeneTgene
Gene symbol

IGHG1

GOLGA8A

Gene ID

3500

23015

Gene nameimmunoglobulin heavy constant gamma 1 (G1m marker)golgin A8 family member A
Synonyms-GM88
Cytomap

14q32.33

15q14

Type of geneotherprotein-coding
Descriptionconstant region of heavy chain of IgG1immunoglobulin gamma 1 (Gm marker)golgin subfamily A member 8A88 kDa Golgi matrix protein88-kDa golgi proteinGM88 autoantigengolgi autoantigen, golgin subfamily a, 8Agolgin-67
Modification date2018052320180523
UniProtAcc

P01857

A7E2F4

Ensembl transtripts involved in fusion geneENST00000390548, ENST00000543376, 
ENST00000432566, ENST00000360553, 
ENST00000359187, ENST00000565885, 
Fusion gene scores* DoF score43 X 54 X 5=116103 X 3 X 2=18
# samples 593
** MAII scorelog2(59/11610*10)=-4.29850920750373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IGHG1 [Title/Abstract] AND GOLGA8A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF878903IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000390548ENST00000543376IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-
intron-3CDSENST00000390548ENST00000432566IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-
intron-3CDSENST00000390548ENST00000360553IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-
intron-3CDSENST00000390548ENST00000359187IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-
intron-intronENST00000390548ENST00000565885IGHG1chr14

106235792

-GOLGA8Achr15

34674245

-

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FusionProtFeatures for IGHG1_GOLGA8A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGHG1

P01857

GOLGA8A

A7E2F4

Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGHG1_GOLGA8A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGHG1_GOLGA8A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGHG1_GOLGA8A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGHG1_GOLGA8A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGHG1C0027121Myositis1CTD_human
HgeneIGHG1C0032460Polycystic Ovary Syndrome1CTD_human