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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17209

FusionGeneSummary for IGFBP7_PLXNA4

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP7_PLXNA4
Fusion gene ID: 17209
HgeneTgene
Gene symbol

IGFBP7

PLXNA4

Gene ID

3490

91584

Gene nameinsulin like growth factor binding protein 7plexin A4
SynonymsAGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAFFAYV2820|PLEXA4|PLXNA4A|PLXNA4B|PRO34003
Cytomap

4q12

7q32.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factorplexin-A4
Modification date2018052220180523
UniProtAcc

Q16270

Q9HCM2

Ensembl transtripts involved in fusion geneENST00000295666, ENST00000537922, 
ENST00000512512, 
ENST00000321063, 
ENST00000359827, ENST00000423507, 
ENST00000378539, 
Fusion gene scores* DoF score5 X 5 X 2=501 X 1 X 1=1
# samples 51
** MAII scorelog2(5/50*10)=0log2(1/1*10)=3.32192809488736
Context

PubMed: IGFBP7 [Title/Abstract] AND PLXNA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP7

GO:0007155

cell adhesion

8117260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T05904IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000295666ENST00000321063IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-3UTRENST00000295666ENST00000359827IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000295666ENST00000423507IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000295666ENST00000378539IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-3UTRENST00000537922ENST00000321063IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-3UTRENST00000537922ENST00000359827IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000537922ENST00000423507IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000537922ENST00000378539IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-3UTRENST00000512512ENST00000321063IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-3UTRENST00000512512ENST00000359827IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000512512ENST00000423507IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+
intron-intronENST00000512512ENST00000378539IGFBP7chr4

57907100

+PLXNA4chr7

131810602

+

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FusionProtFeatures for IGFBP7_PLXNA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP7

Q16270

PLXNA4

Q9HCM2

Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFBP7_PLXNA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFBP7_PLXNA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFBP7_PLXNA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGFBP7Q16270DB00071Insulin PorkInsulin-like growth factor-binding protein 7biotechapproved
HgeneIGFBP7Q16270DB00030Insulin HumanInsulin-like growth factor-binding protein 7biotechapproved|investigational

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RelatedDiseases for IGFBP7_PLXNA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGFBP7C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneIGFBP7C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGFBP7C0033578Prostatic Neoplasms1CTD_human
HgeneIGFBP7C0038356Stomach Neoplasms1CTD_human
HgeneIGFBP7C1458155Mammary Neoplasms1CTD_human