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Fusion gene ID: 17209 |
FusionGeneSummary for IGFBP7_PLXNA4 |
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Fusion gene information | Fusion gene name: IGFBP7_PLXNA4 | Fusion gene ID: 17209 | Hgene | Tgene | Gene symbol | IGFBP7 | PLXNA4 | Gene ID | 3490 | 91584 |
Gene name | insulin like growth factor binding protein 7 | plexin A4 | |
Synonyms | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | FAYV2820|PLEXA4|PLXNA4A|PLXNA4B|PRO34003 | |
Cytomap | 4q12 | 7q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | plexin-A4 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q16270 | Q9HCM2 | |
Ensembl transtripts involved in fusion gene | ENST00000295666, ENST00000537922, ENST00000512512, | ENST00000321063, ENST00000359827, ENST00000423507, ENST00000378539, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/50*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: IGFBP7 [Title/Abstract] AND PLXNA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T05904 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000295666 | ENST00000321063 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-3UTR | ENST00000295666 | ENST00000359827 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000295666 | ENST00000423507 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000295666 | ENST00000378539 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-3UTR | ENST00000537922 | ENST00000321063 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-3UTR | ENST00000537922 | ENST00000359827 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000537922 | ENST00000423507 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000537922 | ENST00000378539 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-3UTR | ENST00000512512 | ENST00000321063 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-3UTR | ENST00000512512 | ENST00000359827 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000512512 | ENST00000423507 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
intron-intron | ENST00000512512 | ENST00000378539 | IGFBP7 | chr4 | 57907100 | + | PLXNA4 | chr7 | 131810602 | + |
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FusionProtFeatures for IGFBP7_PLXNA4 |
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Hgene | Tgene |
IGFBP7 | PLXNA4 |
Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IGFBP7_PLXNA4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IGFBP7_PLXNA4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGFBP7_PLXNA4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | IGFBP7 | Q16270 | DB00071 | Insulin Pork | Insulin-like growth factor-binding protein 7 | biotech | approved |
Hgene | IGFBP7 | Q16270 | DB00030 | Insulin Human | Insulin-like growth factor-binding protein 7 | biotech | approved|investigational |
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RelatedDiseases for IGFBP7_PLXNA4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IGFBP7 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | IGFBP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | IGFBP7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | IGFBP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | IGFBP7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |