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Fusion gene ID: 17207 |
FusionGeneSummary for IGFBP7_HYAL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGFBP7_HYAL2 | Fusion gene ID: 17207 | Hgene | Tgene | Gene symbol | IGFBP7 | HYAL2 | Gene ID | 3490 | 8692 |
| Gene name | insulin like growth factor binding protein 7 | hyaluronoglucosaminidase 2 | |
| Synonyms | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | LUCA2 | |
| Cytomap | 4q12 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | hyaluronidase-2PH-20 homologPH20 homologhyal-2lung carcinoma protein 2lysosomal hyaluronidase | |
| Modification date | 20180522 | 20180520 | |
| UniProtAcc | Q16270 | Q12891 | |
| Ensembl transtripts involved in fusion gene | ENST00000295666, ENST00000537922, ENST00000512512, | ENST00000447092, ENST00000357750, ENST00000395139, ENST00000442581, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/50*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: IGFBP7 [Title/Abstract] AND HYAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
| Tgene | HYAL2 | GO:0000302 | response to reactive oxygen species | 20554532 |
| Tgene | HYAL2 | GO:0006027 | glycosaminoglycan catabolic process | 9712871 |
| Tgene | HYAL2 | GO:0009615 | response to virus | 11296287|12676986 |
| Tgene | HYAL2 | GO:0010764 | negative regulation of fibroblast migration | 19577615 |
| Tgene | HYAL2 | GO:0019064 | fusion of virus membrane with host plasma membrane | 11296287 |
| Tgene | HYAL2 | GO:0019087 | transformation of host cell by virus | 11296287 |
| Tgene | HYAL2 | GO:0030214 | hyaluronan catabolic process | 17170110|19443707|20554532|21699545 |
| Tgene | HYAL2 | GO:0030308 | negative regulation of cell growth | 18725949 |
| Tgene | HYAL2 | GO:0042117 | monocyte activation | 19443707 |
| Tgene | HYAL2 | GO:0043407 | negative regulation of MAP kinase activity | 12676986 |
| Tgene | HYAL2 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 19577615 |
| Tgene | HYAL2 | GO:0050729 | positive regulation of inflammatory response | 19443707 |
| Tgene | HYAL2 | GO:0051898 | negative regulation of protein kinase B signaling | 12676986 |
| Tgene | HYAL2 | GO:0061099 | negative regulation of protein tyrosine kinase activity | 12676986 |
| Tgene | HYAL2 | GO:0071347 | cellular response to interleukin-1 | 18390475 |
| Tgene | HYAL2 | GO:0071493 | cellular response to UV-B | 21699545 |
| Tgene | HYAL2 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 19366691 |
| Tgene | HYAL2 | GO:2000484 | positive regulation of interleukin-8 secretion | 19443707 |
| Tgene | HYAL2 | GO:2000778 | positive regulation of interleukin-6 secretion | 19443707 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF853827 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000295666 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
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FusionProtFeatures for IGFBP7_HYAL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGFBP7 | HYAL2 |
| Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}. | Hydrolyzes high molecular weight hyaluronic acid toproduce an intermediate-sized product which is further hydrolyzedby sperm hyaluronidase to give small oligosaccharides. Displaysvery low levels of activity. Associates with and negativelyregulates MST1R. {ECO:0000269|PubMed:11296287,ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IGFBP7_HYAL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IGFBP7_HYAL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGFBP7_HYAL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IGFBP7 | Q16270 | DB00071 | Insulin Pork | Insulin-like growth factor-binding protein 7 | biotech | approved |
| Hgene | IGFBP7 | Q16270 | DB00030 | Insulin Human | Insulin-like growth factor-binding protein 7 | biotech | approved|investigational |
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RelatedDiseases for IGFBP7_HYAL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IGFBP7 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | IGFBP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | IGFBP7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | IGFBP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | IGFBP7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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