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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17184

FusionGeneSummary for IGFBP3_ANTXR2

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP3_ANTXR2
Fusion gene ID: 17184
HgeneTgene
Gene symbol

IGFBP3

ANTXR2

Gene ID

3486

118429

Gene nameinsulin like growth factor binding protein 3ANTXR cell adhesion molecule 2
SynonymsBP-53|IBP3CMG-2|CMG2|HFS|ISH|JHF
Cytomap

7p12.3

4q21.21

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding proteinanthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2
Modification date2018052720180523
UniProtAcc

P17936

P58335

Ensembl transtripts involved in fusion geneENST00000381086, ENST00000275521, 
ENST00000381083, ENST00000465642, 
ENST00000403729, ENST00000482406, 
ENST00000404191, ENST00000346652, 
ENST00000307333, ENST00000295465, 
Fusion gene scores* DoF score6 X 6 X 2=726 X 7 X 3=126
# samples 77
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFBP3 [Title/Abstract] AND ANTXR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP3

GO:0001933

negative regulation of protein phosphorylation

17591901

HgeneIGFBP3

GO:0006468

protein phosphorylation

17434920

HgeneIGFBP3

GO:0014912

negative regulation of smooth muscle cell migration

10766744

HgeneIGFBP3

GO:0045663

positive regulation of myoblast differentiation

12599210

HgeneIGFBP3

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB318377IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000381086ENST00000403729IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-5UTRENST00000381086ENST00000482406IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000381086ENST00000404191IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381086ENST00000346652IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381086ENST00000307333IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381086ENST00000295465IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000275521ENST00000403729IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-5UTRENST00000275521ENST00000482406IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000275521ENST00000404191IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000275521ENST00000346652IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000275521ENST00000307333IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000275521ENST00000295465IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000381083ENST00000403729IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-5UTRENST00000381083ENST00000482406IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000381083ENST00000404191IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381083ENST00000346652IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381083ENST00000307333IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000381083ENST00000295465IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000465642ENST00000403729IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-5UTRENST00000465642ENST00000482406IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-3UTRENST00000465642ENST00000404191IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000465642ENST00000346652IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000465642ENST00000307333IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+
intron-intronENST00000465642ENST00000295465IGFBP3chr7

45952180

+ANTXR2chr4

80828557

+

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FusionProtFeatures for IGFBP3_ANTXR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP3

P17936

ANTXR2

P58335

IGF-binding proteins prolong the half-life of the IGFsand have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors. Alsoexhibits IGF-independent antiproliferative and apoptotic effectsmediated by its receptor TMEM219/IGFBP-3R.{ECO:0000269|PubMed:20353938}. Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IGFBP3_ANTXR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IGFBP3_ANTXR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGFBP3_ANTXR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGFBP3P17936DB00523AlitretinoinInsulin-like growth factor-binding protein 3small moleculeapproved|investigational
HgeneIGFBP3P17936DB01277MecaserminInsulin-like growth factor-binding protein 3biotechapproved|investigational

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RelatedDiseases for IGFBP3_ANTXR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGFBP3C0033578Prostatic Neoplasms3CTD_human
HgeneIGFBP3C0000786Spontaneous abortion1CTD_human
HgeneIGFBP3C0003873Rheumatoid Arthritis1CTD_human
HgeneIGFBP3C0004352Autistic Disorder1CTD_human
HgeneIGFBP3C0005695Bladder Neoplasm1CTD_human
HgeneIGFBP3C0007138Carcinoma, Transitional Cell1CTD_human
HgeneIGFBP3C0009404Colorectal Neoplasms1CTD_human
HgeneIGFBP3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGFBP3C0038356Stomach Neoplasms1CTD_human
HgeneIGFBP3C0151744Myocardial Ischemia1CTD_human
TgeneANTXR2C0009917Contracture2CTD_human
TgeneANTXR2C0016045fibroma2CTD_human
TgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
TgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
TgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
TgeneANTXR2C0029456Osteoporosis1CTD_human
TgeneANTXR2C0221204Lytic lesion1CTD_human