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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17168

FusionGeneSummary for IGF2R_SYTL3

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2R_SYTL3
Fusion gene ID: 17168
HgeneTgene
Gene symbol

IGF2R

SYTL3

Gene ID

3482

94120

Gene nameinsulin like growth factor 2 receptorsynaptotagmin like 3
SynonymsCD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRISLP3
Cytomap

6q25.3

6q25.3

Type of geneprotein-codingprotein-coding
Descriptioncation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptorsynaptotagmin-like protein 3exophilin-6
Modification date2018052720180523
UniProtAcc

P11717

Q4VX76

Ensembl transtripts involved in fusion geneENST00000356956, ENST00000475584, 
ENST00000360448, ENST00000297239, 
ENST00000367081, ENST00000469735, 
Fusion gene scores* DoF score7 X 6 X 6=2523 X 3 X 3=27
# samples 63
** MAII scorelog2(6/252*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IGF2R [Title/Abstract] AND SYTL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2800-01AIGF2Rchr6

160390427

+SYTL3chr6

159129354

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356956ENST00000360448IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
In-frameENST00000356956ENST00000297239IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
5CDS-intronENST00000356956ENST00000367081IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
5CDS-intronENST00000356956ENST00000469735IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
intron-3CDSENST00000475584ENST00000360448IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
intron-3CDSENST00000475584ENST00000297239IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
intron-intronENST00000475584ENST00000367081IGF2Rchr6

160390427

+SYTL3chr6

159129354

+
intron-intronENST00000475584ENST00000469735IGF2Rchr6

160390427

+SYTL3chr6

159129354

+

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FusionProtFeatures for IGF2R_SYTL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2R

P11717

SYTL3

Q4VX76

Transport of phosphorylated lysosomal enzymes from theGolgi complex and the cell surface to lysosomes. Lysosomal enzymesbearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resultingreceptor-ligand complex is transported to an acidic prelyosomalcompartment where the low pH mediates the dissociation of thecomplex. This receptor also binds IGF2. Acts as a positiveregulator of T-cell coactivation, by binding DPP4.{ECO:0000269|PubMed:10900005}. May act as Rab effector protein and play a role invesicle trafficking. Binds phospholipids in the presence ofcalcium ions (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYTL3chr6:160390427chr6:159129354ENST00000297239+517308_412148611DomainC2 1
TgeneSYTL3chr6:160390427chr6:159129354ENST00000297239+517467_571148611DomainC2 2
TgeneSYTL3chr6:160390427chr6:159129354ENST00000360448+717308_412148543DomainC2 1
TgeneSYTL3chr6:160390427chr6:159129354ENST00000360448+717467_571148543DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481898_1944492492DomainFibronectin type-II
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481100_1243492492RepeatNote=8
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481244_1384492492RepeatNote=9
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481385_1532492492RepeatNote=10
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481533_1666492492RepeatNote=11
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481667_1820492492RepeatNote=12
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1481821_2008492492RepeatNote=13
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148190_344492492RepeatNote=2
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1482009_2137492492RepeatNote=14
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1482165_2289492492RepeatNote=15
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148345_489492492RepeatNote=3
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+14840_189492492RepeatNote=1
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148490_643492492RepeatNote=4
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148644_783492492RepeatNote=5
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148784_950492492RepeatNote=6
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+148951_1099492492RepeatNote=7
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1482328_2491492492Topological domainCytoplasmic
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+14841_2304492492Topological domainLumenal
HgeneIGF2Rchr6:160390427chr6:159129354ENST00000356956+1482305_2327492492TransmembraneHelical
TgeneSYTL3chr6:160390427chr6:159129354ENST00000297239+5174_123148611DomainRabBD
TgeneSYTL3chr6:160390427chr6:159129354ENST00000360448+7174_123148543DomainRabBD


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FusionGeneSequence for IGF2R_SYTL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000360448_chr6_159129354_+_444aa
MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSKISVVPPTPPPVSESQCSRSPGRKVSAPDILKPLNQEDPK
CSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYV
KTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKA
EKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQA

>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000297239_chr6_159129354_+_512aa
MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSKISVVPPTPPPVSESQCSRSPGRLQEFGQFRGFNKSVENL
FLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIF
SGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNT
VDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVL
PSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000360448_chr6_159129354_+_1332nt
ATGGGGGCCGCCGCCGGCCGGAGCCCCCACCTGGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTG
CTCGTCGCTGCCCCGGGGTCCACGCAGGCCCAGGCCGCCCCGTTCCCCGAGCTGTGCAGCAAAATTTCTGTGGTTCCTCCTACTCCACCT
CCTGTCAGCGAGAGCCAGTGCAGCCGCAGTCCTGGCAGGAAGGTCAGTGCACCAGATATTCTGAAACCTCTCAATCAAGAGGATCCCAAA
TGCTCTACTAACCCTATTTTGAAGCAACAGAATCTCCCATCCAGTCCGGCACCCAGTACCATATTCTCTGGAGGTTTTAGACACGGAAGT
TTAATTAGCATTGACAGCACCTGTACAGAGATGGGCAATTTTGACAATGCTAATGTCACTGGAGAAATAGAATTTGCCATTCATTATTGC
TTCAAAACCCATTCTTTAGAAATATGCATCAAGGCCTGTAAGAACCTTGCCTATGGAGAAGAAAAGAAGAAAAAGTGCAATCCGTATGTG
AAGACCTACCTGTTGCCCGACAGATCCTCCCAGGGAAAGCGCAAGACTGGAGTCCAAAGGAACACCGTGGACCCGACCTTTCAGGAGACC
TTGAAGTATCAGGTGGCCCCTGCCCAGCTGGTGACCCGGCAGCTGCAGGTCTCGGTGTGGCATCTGGGCACGCTGGCCCGGAGAGTGTTT
CTTGGAGAAGTGATCATTCCTCTGGCCACGTGGGACTTTGAAGACAGCACAACACAGTCCTTCCGCTGGCATCCGCTCCGGGCCAAGGCG
GAGAAATACGAAGACAGCGTTCCTCAGAGTAATGGAGAGCTCACAGTCCGGGCTAAGCTGGTTCTCCCTTCACGGCCCAGAAAACTCCAA
GAGGCTCAAGAAGGGACAGATCAGCCATCACTTCATGGTCAACTTTGTTTGGTAGTGCTAGGAGCCAAGAATTTACCTGTGCGGCCAGAT
GGCACCTTGAACTCATTTGTTAAGGGCTGTCTCACTCTGCCAGACCAACAAAAACTGAGACTGAAGTCGCCAGTCCTGAGGAAGCAGGCT
TGCCCCCAGTGGAAACACTCATTTGTCTTCAGTGGCGTAACCCCAGCTCAGCTGAGGCAGTCAAGCTTGGAGTTAACTGTCTGGGATCAG
GCCCTCTTTGGAATGAACGACCGCTTGCTTGGAGGAACCAGACTTGGTTCAAAGGGAGACACAGCTGTTGGCGGGGATGCATGCTCACTA

>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000297239_chr6_159129354_+_1536nt
ATGGGGGCCGCCGCCGGCCGGAGCCCCCACCTGGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTG
CTCGTCGCTGCCCCGGGGTCCACGCAGGCCCAGGCCGCCCCGTTCCCCGAGCTGTGCAGCAAAATTTCTGTGGTTCCTCCTACTCCACCT
CCTGTCAGCGAGAGCCAGTGCAGCCGCAGTCCTGGCAGGTTACAGGAATTTGGTCAGTTTAGAGGATTTAATAAGTCCGTGGAAAATTTG
TTTCTGTCTCTTGCTACCCACGTGAAAAAGCTCTCCAAATCCCAGAATGATATGACTTCTGAGAAGCATCTTCTCGCCACGGGCCCCAGG
CAGTGTGTGGGACAGACAGAGAGACGGAGCCAGTCTGACACTGCGGTCAACGTCACCACCAGGAAGGTCAGTGCACCAGATATTCTGAAA
CCTCTCAATCAAGAGGATCCCAAATGCTCTACTAACCCTATTTTGAAGCAACAGAATCTCCCATCCAGTCCGGCACCCAGTACCATATTC
TCTGGAGGTTTTAGACACGGAAGTTTAATTAGCATTGACAGCACCTGTACAGAGATGGGCAATTTTGACAATGCTAATGTCACTGGAGAA
ATAGAATTTGCCATTCATTATTGCTTCAAAACCCATTCTTTAGAAATATGCATCAAGGCCTGTAAGAACCTTGCCTATGGAGAAGAAAAG
AAGAAAAAGTGCAATCCGTATGTGAAGACCTACCTGTTGCCCGACAGATCCTCCCAGGGAAAGCGCAAGACTGGAGTCCAAAGGAACACC
GTGGACCCGACCTTTCAGGAGACCTTGAAGTATCAGGTGGCCCCTGCCCAGCTGGTGACCCGGCAGCTGCAGGTCTCGGTGTGGCATCTG
GGCACGCTGGCCCGGAGAGTGTTTCTTGGAGAAGTGATCATTCCTCTGGCCACGTGGGACTTTGAAGACAGCACAACACAGTCCTTCCGC
TGGCATCCGCTCCGGGCCAAGGCGGAGAAATACGAAGACAGCGTTCCTCAGAGTAATGGAGAGCTCACAGTCCGGGCTAAGCTGGTTCTC
CCTTCACGGCCCAGAAAACTCCAAGAGGCTCAAGAAGGGACAGATCAGCCATCACTTCATGGTCAACTTTGTTTGGTAGTGCTAGGAGCC
AAGAATTTACCTGTGCGGCCAGATGGCACCTTGAACTCATTTGTTAAGGGCTGTCTCACTCTGCCAGACCAACAAAAACTGAGACTGAAG
TCGCCAGTCCTGAGGAAGCAGGCTTGCCCCCAGTGGAAACACTCATTTGTCTTCAGTGGCGTAACCCCAGCTCAGCTGAGGCAGTCAAGC
TTGGAGTTAACTGTCTGGGATCAGGCCCTCTTTGGAATGAACGACCGCTTGCTTGGAGGAACCAGACTTGGTTCAAAGGGAGACACAGCT
GTTGGCGGGGATGCATGCTCACTATCGAAGCTCCAGTGGCAGAAAGTCCTTTCCAGCCCCAATCTATGGACAGACATGACTCTTGTCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000360448_chr6_159129354_+_1745nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGCAAAATTTCTGTGGTTCCTCCTACTCCACCTCCTGTCAGCGAGAGCCAGTGCAGCCGCAGTCC
TGGCAGGAAGGTCAGTGCACCAGATATTCTGAAACCTCTCAATCAAGAGGATCCCAAATGCTCTACTAACCCTATTTTGAAGCAACAGAA
TCTCCCATCCAGTCCGGCACCCAGTACCATATTCTCTGGAGGTTTTAGACACGGAAGTTTAATTAGCATTGACAGCACCTGTACAGAGAT
GGGCAATTTTGACAATGCTAATGTCACTGGAGAAATAGAATTTGCCATTCATTATTGCTTCAAAACCCATTCTTTAGAAATATGCATCAA
GGCCTGTAAGAACCTTGCCTATGGAGAAGAAAAGAAGAAAAAGTGCAATCCGTATGTGAAGACCTACCTGTTGCCCGACAGATCCTCCCA
GGGAAAGCGCAAGACTGGAGTCCAAAGGAACACCGTGGACCCGACCTTTCAGGAGACCTTGAAGTATCAGGTGGCCCCTGCCCAGCTGGT
GACCCGGCAGCTGCAGGTCTCGGTGTGGCATCTGGGCACGCTGGCCCGGAGAGTGTTTCTTGGAGAAGTGATCATTCCTCTGGCCACGTG
GGACTTTGAAGACAGCACAACACAGTCCTTCCGCTGGCATCCGCTCCGGGCCAAGGCGGAGAAATACGAAGACAGCGTTCCTCAGAGTAA
TGGAGAGCTCACAGTCCGGGCTAAGCTGGTTCTCCCTTCACGGCCCAGAAAACTCCAAGAGGCTCAAGAAGGGACAGATCAGCCATCACT
TCATGGTCAACTTTGTTTGGTAGTGCTAGGAGCCAAGAATTTACCTGTGCGGCCAGATGGCACCTTGAACTCATTTGTTAAGGGCTGTCT
CACTCTGCCAGACCAACAAAAACTGAGACTGAAGTCGCCAGTCCTGAGGAAGCAGGCTTGCCCCCAGTGGAAACACTCATTTGTCTTCAG
TGGCGTAACCCCAGCTCAGCTGAGGCAGTCAAGCTTGGAGTTAACTGTCTGGGATCAGGCCCTCTTTGGAATGAACGACCGCTTGCTTGG
AGGAACCAGACTTGGTTCAAAGGGAGACACAGCTGTTGGCGGGGATGCATGCTCACTATCGAAGCTCCAGTGGCAGAAAGTCCTTTCCAG
CCCCAATCTATGGACAGACATGACTCTTGTCCTGCACTGACATGAAGGCCTCAAGGTTCCAGGTTGCAGCAGGCGTGAGGCACTGTGCGT
CTGCAGAGGGGCTACGAACCAGGTGCAGGGTCCCAGCTGGAGACCCCTTTGACCTTGAGCAGTCTCCATCTGCGGCCCTGTCCCATGGCT
TAACCGCCTATTGGTATCTGTGTATATTTACGTTAAACACAATTATGTTACCTAAGCCTCTGGTGGGTTATCTCCTCTTTGAGATGTAGA

>In-frame_IGF2R_ENST00000356956_chr6_160390427_+_SYTL3_ENST00000297239_chr6_159129354_+_1949nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGCAAAATTTCTGTGGTTCCTCCTACTCCACCTCCTGTCAGCGAGAGCCAGTGCAGCCGCAGTCC
TGGCAGGTTACAGGAATTTGGTCAGTTTAGAGGATTTAATAAGTCCGTGGAAAATTTGTTTCTGTCTCTTGCTACCCACGTGAAAAAGCT
CTCCAAATCCCAGAATGATATGACTTCTGAGAAGCATCTTCTCGCCACGGGCCCCAGGCAGTGTGTGGGACAGACAGAGAGACGGAGCCA
GTCTGACACTGCGGTCAACGTCACCACCAGGAAGGTCAGTGCACCAGATATTCTGAAACCTCTCAATCAAGAGGATCCCAAATGCTCTAC
TAACCCTATTTTGAAGCAACAGAATCTCCCATCCAGTCCGGCACCCAGTACCATATTCTCTGGAGGTTTTAGACACGGAAGTTTAATTAG
CATTGACAGCACCTGTACAGAGATGGGCAATTTTGACAATGCTAATGTCACTGGAGAAATAGAATTTGCCATTCATTATTGCTTCAAAAC
CCATTCTTTAGAAATATGCATCAAGGCCTGTAAGAACCTTGCCTATGGAGAAGAAAAGAAGAAAAAGTGCAATCCGTATGTGAAGACCTA
CCTGTTGCCCGACAGATCCTCCCAGGGAAAGCGCAAGACTGGAGTCCAAAGGAACACCGTGGACCCGACCTTTCAGGAGACCTTGAAGTA
TCAGGTGGCCCCTGCCCAGCTGGTGACCCGGCAGCTGCAGGTCTCGGTGTGGCATCTGGGCACGCTGGCCCGGAGAGTGTTTCTTGGAGA
AGTGATCATTCCTCTGGCCACGTGGGACTTTGAAGACAGCACAACACAGTCCTTCCGCTGGCATCCGCTCCGGGCCAAGGCGGAGAAATA
CGAAGACAGCGTTCCTCAGAGTAATGGAGAGCTCACAGTCCGGGCTAAGCTGGTTCTCCCTTCACGGCCCAGAAAACTCCAAGAGGCTCA
AGAAGGGACAGATCAGCCATCACTTCATGGTCAACTTTGTTTGGTAGTGCTAGGAGCCAAGAATTTACCTGTGCGGCCAGATGGCACCTT
GAACTCATTTGTTAAGGGCTGTCTCACTCTGCCAGACCAACAAAAACTGAGACTGAAGTCGCCAGTCCTGAGGAAGCAGGCTTGCCCCCA
GTGGAAACACTCATTTGTCTTCAGTGGCGTAACCCCAGCTCAGCTGAGGCAGTCAAGCTTGGAGTTAACTGTCTGGGATCAGGCCCTCTT
TGGAATGAACGACCGCTTGCTTGGAGGAACCAGACTTGGTTCAAAGGGAGACACAGCTGTTGGCGGGGATGCATGCTCACTATCGAAGCT
CCAGTGGCAGAAAGTCCTTTCCAGCCCCAATCTATGGACAGACATGACTCTTGTCCTGCACTGACATGAAGGCCTCAAGGTTCCAGGTTG
CAGCAGGCGTGAGGCACTGTGCGTCTGCAGAGGGGCTACGAACCAGGTGCAGGGTCCCAGCTGGAGACCCCTTTGACCTTGAGCAGTCTC
CATCTGCGGCCCTGTCCCATGGCTTAACCGCCTATTGGTATCTGTGTATATTTACGTTAAACACAATTATGTTACCTAAGCCTCTGGTGG


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FusionGenePPI for IGF2R_SYTL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IGF2RCREG1, PLIN3, PLAUR, USP50, ELAVL1, MYC, SIRT7, GGA2, GGA3, GGA1, CSNK2A1, FBXO6, TM9SF4, COA7, SERINC1, TIMM10B, ATXN1, FN1, CCDC8, ABCE1, EWSR1, TMEM17, TMEM216, RAB5C, XRCC5, GTSE1, CHMP4B, CDH1, PPM1H, NCDN, TRIM25SYTL3RAB27A, RAB10, RAB27B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IGF2R_SYTL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGF2RP11717DB01277MecaserminCation-independent mannose-6-phosphate receptorbiotechapproved|investigational

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RelatedDiseases for IGF2R_SYTL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2RC0024115Lung diseases2CTD_human
HgeneIGF2RC0235833Congenital diaphragmatic hernia2CTD_human
HgeneIGF2RC0002395Alzheimer's Disease1CTD_human
HgeneIGF2RC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGF2RC0030567Parkinson Disease1CTD_human
HgeneIGF2RC0752347Lewy Body Disease1CTD_human
HgeneIGF2RC2239176Liver carcinoma1CTD_human;HPO