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Fusion gene ID: 17167 |
FusionGeneSummary for IGF2R_SLC22A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGF2R_SLC22A3 | Fusion gene ID: 17167 | Hgene | Tgene | Gene symbol | IGF2R | SLC22A3 | Gene ID | 3482 | 6581 |
| Gene name | insulin like growth factor 2 receptor | solute carrier family 22 member 3 | |
| Synonyms | CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI | EMT|EMTH|OCT3 | |
| Cytomap | 6q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptor | solute carrier family 22 member 3EMT organic cation transporter 3extraneuronal monoamine transporterorganic cation transporter 3solute carrier family 22 (extraneuronal monoamine transporter), member 3solute carrier family 22 (organic cation transport | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P11717 | O75751 | |
| Ensembl transtripts involved in fusion gene | ENST00000356956, ENST00000475584, | ENST00000275300, ENST00000392145, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 2 X 2 X 2=8 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/252*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: IGF2R [Title/Abstract] AND SLC22A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC22A3 | GO:0015695 | organic cation transport | 10966924|16024787 |
| Tgene | SLC22A3 | GO:0015697 | quaternary ammonium group transport | 10966924 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0BL-01A | IGF2R | chr6 | 160431817 | + | SLC22A3 | chr6 | 160819011 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356956 | ENST00000275300 | IGF2R | chr6 | 160431817 | + | SLC22A3 | chr6 | 160819011 | + |
| In-frame | ENST00000356956 | ENST00000392145 | IGF2R | chr6 | 160431817 | + | SLC22A3 | chr6 | 160819011 | + |
| intron-3CDS | ENST00000475584 | ENST00000275300 | IGF2R | chr6 | 160431817 | + | SLC22A3 | chr6 | 160819011 | + |
| intron-3CDS | ENST00000475584 | ENST00000392145 | IGF2R | chr6 | 160431817 | + | SLC22A3 | chr6 | 160819011 | + |
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FusionProtFeatures for IGF2R_SLC22A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGF2R | SLC22A3 |
| Transport of phosphorylated lysosomal enzymes from theGolgi complex and the cell surface to lysosomes. Lysosomal enzymesbearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resultingreceptor-ligand complex is transported to an acidic prelyosomalcompartment where the low pH mediates the dissociation of thecomplex. This receptor also binds IGF2. Acts as a positiveregulator of T-cell coactivation, by binding DPP4.{ECO:0000269|PubMed:10900005}. | Mediates potential-dependent transport of a variety oforganic cations. May play a significant role in the disposition ofcationic neurotoxins and neurotransmitters in the brain.{ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 182_202 | 143 | 557 | Transmembrane | Helical |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 241_261 | 143 | 557 | Transmembrane | Helical |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 269_289 | 143 | 557 | Transmembrane | Helical |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 381_401 | 143 | 557 | Transmembrane | Helical |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 468_488 | 143 | 557 | Transmembrane | Helical |
| Tgene | >SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 498_518 | 143 | 557 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1898_1944 | 171 | 2492 | Domain | Fibronectin type-II |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1100_1243 | 171 | 2492 | Repeat | Note=8 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1244_1384 | 171 | 2492 | Repeat | Note=9 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1385_1532 | 171 | 2492 | Repeat | Note=10 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1533_1666 | 171 | 2492 | Repeat | Note=11 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1667_1820 | 171 | 2492 | Repeat | Note=12 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 1821_2008 | 171 | 2492 | Repeat | Note=13 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 190_344 | 171 | 2492 | Repeat | Note=2 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 2009_2137 | 171 | 2492 | Repeat | Note=14 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 2165_2289 | 171 | 2492 | Repeat | Note=15 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 345_489 | 171 | 2492 | Repeat | Note=3 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 40_189 | 171 | 2492 | Repeat | Note=1 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 490_643 | 171 | 2492 | Repeat | Note=4 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 644_783 | 171 | 2492 | Repeat | Note=5 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 784_950 | 171 | 2492 | Repeat | Note=6 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 951_1099 | 171 | 2492 | Repeat | Note=7 |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 2328_2491 | 171 | 2492 | Topological domain | Cytoplasmic |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 41_2304 | 171 | 2492 | Topological domain | Lumenal |
| Hgene | >IGF2R | chr6:160431817 | chr6:160819011 | ENST00000356956 | + | 4 | 48 | 2305_2327 | 171 | 2492 | Transmembrane | Helical |
| Tgene | SLC22A3 | chr6:160431817 | chr6:160819011 | ENST00000275300 | + | 0 | 11 | 21_41 | 143 | 557 | Transmembrane | Helical |
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FusionGeneSequence for IGF2R_SLC22A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000275300_chr6_160819011_+_585aa MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKT RTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEFDLVCVNAW MLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEE VSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACL VTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGG >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000392145_chr6_160819011_+_586aa MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKT RTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEFDLVCVNAW MLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEE VSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACL VTAFLPEAGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000275300_chr6_160819011_+_1755nt ATGGGGGCCGCCGCCGGCCGGAGCCCCCACCTGGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTG CTCGTCGCTGCCCCGGGGTCCACGCAGGCCCAGGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAAT AATGTACTTTATAAAATCAACATCTGTGGAAGTGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACA CGCACTTATCATTCAGTGGGTGACTCTGTTTTGAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAA GGCACAAATCACAGAGTCCAGAGCAGCATTGCCTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTG CACTACTTTGAGTGGAGGACCACTGCAGCCTGCAAGAAAGACATATTTAAAGCAAATAAGGAGTTTGACCTTGTCTGTGTCAATGCGTGG ATGCTGGACCTCACCCAAGCCATCCTGAACCTCGGCTTCCTGACTGGAGCATTCACCTTAGGCTATGCAGCAGACAGGTATGGCAGGATC GTCATTTACTTGCTATCCTGCCTTGGTGTTGGCGTCACTGGGGTTGTGGTGGCCTTTGCACCAAACTTCCCTGTGTTTGTGATCTTCCGC TTCCTGCAAGGTGTATTTGGAAAGGGGACGTGGATGACTTGCTACGTGATTGTGACAGAAATAGTAGGTTCGAAACAAAGGAGGATTGTG GGAATCGTGATTCAAATGTTCTTTACCCTTGGAATCATAATTCTCCCTGGAATTGCCTACTTCATCCCCAACTGGCAAGGAATCCAGTTA GCCATCACGCTGCCCAGCTTTCTCTTCCTCCTTTATTACTGGGTGGTCCCTGAGTCTCCCCGTTGGCTGATTACTCGGAAGAAAGGAGAT AAAGCATTACAGATCCTGAGACGCATTGCTAAGTGCAATGGGAAATACCTCTCATCAAATTACTCAGAGATCACTGTTACAGATGAGGAA GTTAGTAATCCATCCTTTTTAGATCTGGTGAGAACTCCCCAAATGAGGAAATGCACACTTATTCTTATGTTTGCTTGGTTCACAAGCGCA GTGGTGTATCAAGGACTTGTCATGCGCCTGGGAATTATAGGGGGCAACCTCTATATAGACTTTTTCATCTCGGGCGTGGTGGAACTGCCA GGAGCTCTCTTGATCTTACTAACCATTGAGCGCCTTGGACGACGCCTCCCCTTTGCGGCAAGCAATATAGTGGCAGGGGTGGCATGCCTT GTCACTGCGTTCTTACCAGAAGGAATAGCATGGTTGAGGACCACAGTGGCTACATTGGGAAGACTAGGGATAACCATGGCCTTTGAAATT GTTTATTTGGTAAATTCAGAATTGTACCCAACAACATTACGAAATTTCGGAGTTTCGCTCTGTTCAGGTCTGTGTGATTTTGGGGGAATC ATAGCCCCATTTCTGCTCTTTCGGCTAGCAGCCGTGTGGCTAGAACTACCTCTGATCATCTTTGGTATCCTGGCATCCATCTGTGGTGGC CTTGTGATGCTTTTGCCTGAAACCAAGGGTATTGCCTTGCCAGAGACAGTGGATGATGTAGAAAAACTTGGCAGTCCACATTCCTGTAAA >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000392145_chr6_160819011_+_1758nt ATGGGGGCCGCCGCCGGCCGGAGCCCCCACCTGGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTG CTCGTCGCTGCCCCGGGGTCCACGCAGGCCCAGGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAAT AATGTACTTTATAAAATCAACATCTGTGGAAGTGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACA CGCACTTATCATTCAGTGGGTGACTCTGTTTTGAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAA GGCACAAATCACAGAGTCCAGAGCAGCATTGCCTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTG CACTACTTTGAGTGGAGGACCACTGCAGCCTGCAAGAAAGACATATTTAAAGCAAATAAGGAGTTTGACCTTGTCTGTGTCAATGCGTGG ATGCTGGACCTCACCCAAGCCATCCTGAACCTCGGCTTCCTGACTGGAGCATTCACCTTAGGCTATGCAGCAGACAGGTATGGCAGGATC GTCATTTACTTGCTATCCTGCCTTGGTGTTGGCGTCACTGGGGTTGTGGTGGCCTTTGCACCAAACTTCCCTGTGTTTGTGATCTTCCGC TTCCTGCAAGGTGTATTTGGAAAGGGGACGTGGATGACTTGCTACGTGATTGTGACAGAAATAGTAGGTTCGAAACAAAGGAGGATTGTG GGAATCGTGATTCAAATGTTCTTTACCCTTGGAATCATAATTCTCCCTGGAATTGCCTACTTCATCCCCAACTGGCAAGGAATCCAGTTA GCCATCACGCTGCCCAGCTTTCTCTTCCTCCTTTATTACTGGGTGGTCCCTGAGTCTCCCCGTTGGCTGATTACTCGGAAGAAAGGAGAT AAAGCATTACAGATCCTGAGACGCATTGCTAAGTGCAATGGGAAATACCTCTCATCAAATTACTCAGAGATCACTGTTACAGATGAGGAA GTTAGTAATCCATCCTTTTTAGATCTGGTGAGAACTCCCCAAATGAGGAAATGCACACTTATTCTTATGTTTGCTTGGTTCACAAGCGCA GTGGTGTATCAAGGACTTGTCATGCGCCTGGGAATTATAGGGGGCAACCTCTATATAGACTTTTTCATCTCGGGCGTGGTGGAACTGCCA GGAGCTCTCTTGATCTTACTAACCATTGAGCGCCTTGGACGACGCCTCCCCTTTGCGGCAAGCAATATAGTGGCAGGGGTGGCATGCCTT GTCACTGCGTTCTTACCAGAAGCAGGAATAGCATGGTTGAGGACCACAGTGGCTACATTGGGAAGACTAGGGATAACCATGGCCTTTGAA ATTGTTTATTTGGTAAATTCAGAATTGTACCCAACAACATTACGAAATTTCGGAGTTTCGCTCTGTTCAGGTCTGTGTGATTTTGGGGGA ATCATAGCCCCATTTCTGCTCTTTCGGCTAGCAGCCGTGTGGCTAGAACTACCTCTGATCATCTTTGGTATCCTGGCATCCATCTGTGGT GGCCTTGTGATGCTTTTGCCTGAAACCAAGGGTATTGCCTTGCCAGAGACAGTGGATGATGTAGAAAAACTTGGCAGTCCACATTCCTGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000275300_chr6_160819011_+_3428nt CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTTT GAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTGC CTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCTG CAAGAAAGACATATTTAAAGCAAATAAGGAGTTTGACCTTGTCTGTGTCAATGCGTGGATGCTGGACCTCACCCAAGCCATCCTGAACCT CGGCTTCCTGACTGGAGCATTCACCTTAGGCTATGCAGCAGACAGGTATGGCAGGATCGTCATTTACTTGCTATCCTGCCTTGGTGTTGG CGTCACTGGGGTTGTGGTGGCCTTTGCACCAAACTTCCCTGTGTTTGTGATCTTCCGCTTCCTGCAAGGTGTATTTGGAAAGGGGACGTG GATGACTTGCTACGTGATTGTGACAGAAATAGTAGGTTCGAAACAAAGGAGGATTGTGGGAATCGTGATTCAAATGTTCTTTACCCTTGG AATCATAATTCTCCCTGGAATTGCCTACTTCATCCCCAACTGGCAAGGAATCCAGTTAGCCATCACGCTGCCCAGCTTTCTCTTCCTCCT TTATTACTGGGTGGTCCCTGAGTCTCCCCGTTGGCTGATTACTCGGAAGAAAGGAGATAAAGCATTACAGATCCTGAGACGCATTGCTAA GTGCAATGGGAAATACCTCTCATCAAATTACTCAGAGATCACTGTTACAGATGAGGAAGTTAGTAATCCATCCTTTTTAGATCTGGTGAG AACTCCCCAAATGAGGAAATGCACACTTATTCTTATGTTTGCTTGGTTCACAAGCGCAGTGGTGTATCAAGGACTTGTCATGCGCCTGGG AATTATAGGGGGCAACCTCTATATAGACTTTTTCATCTCGGGCGTGGTGGAACTGCCAGGAGCTCTCTTGATCTTACTAACCATTGAGCG CCTTGGACGACGCCTCCCCTTTGCGGCAAGCAATATAGTGGCAGGGGTGGCATGCCTTGTCACTGCGTTCTTACCAGAAGGAATAGCATG GTTGAGGACCACAGTGGCTACATTGGGAAGACTAGGGATAACCATGGCCTTTGAAATTGTTTATTTGGTAAATTCAGAATTGTACCCAAC AACATTACGAAATTTCGGAGTTTCGCTCTGTTCAGGTCTGTGTGATTTTGGGGGAATCATAGCCCCATTTCTGCTCTTTCGGCTAGCAGC CGTGTGGCTAGAACTACCTCTGATCATCTTTGGTATCCTGGCATCCATCTGTGGTGGCCTTGTGATGCTTTTGCCTGAAACCAAGGGTAT TGCCTTGCCAGAGACAGTGGATGATGTAGAAAAACTTGGCAGTCCACATTCCTGTAAATGTGGCAGGAATAAGAAAACCCCAGTTTCCCG CTCTCACCTTTGAGGCCCCCGACAAAGACAGAAAGAAGGAGCTATCCAGGAGCTGATCCTCCTTGCAAAGCTGTGCCTTGCAGAGATGCA CGTGTGCATTTCAGCTACATCATGCCGCGCTGTTGTAATACTGTATAAAGACCTCAATCTATCCAGAGTATTTTTATATAATGTTGGATG AGTTAGGATTTGTAATGCTGTTGAAGTTTCTGGGAACACATAATATGTAGCCAGTTTAACAAAGAAGCTGTCAGGTGCACAGCCCTTCCT GGGTTTTTTTCTTGTGTTCCCTGTGGTCTCTGACCCATTAGGCTAAAGAGAGACAAGAGAAGCCCCCAACCTGATTCTCATGACAGCTCC ATCAAGAATGTGGGATGTGCCGACCAAGGATTTGAGAAAGTTGTACAGAAATGTGTTCATCAAATCTGGTCAAGGGACTAAGCTCCTAGC TGACCATTCATTCTGAAGATTGCATGGAGGATGAACATCTGGGAATCCTGTTAATGAGAAGGCTGAATCACAGGCACCTGGGCCAAAGGG TGTGAGCATTCATGTTCTCTGCTCACCTTGGTTTCCGCACACCTTCGCAATGTGAACAGGTCAGGAGTCCCTCCCGTCCACCTCCTCTGT AACAGCTGGGGTTCCAGGCATGGTTTAGGCCCTGTTCCAGCAATAAGAACCAATCTGCTGTACAATCTGAGGACTTGGCTCTGTTATTTA CAAAATGATGCTGTGGTTCTGAGATTATTTGGGACATTTTTGGCTCTCCTTTAGTGGACACCTAGAGCCACAGATTCCCTTCTTTACTAA ACAAATCCCATGGATTCTGATTTCTGGGTCTTAGGATTTTAAAAGTGAAGGGATATTTTTCTTATATTTGTGAGTTCAGTTCCGATGGTG CCCGTGGTCAAAAGCGAAAAACATGGACAATTCCTATTCATTCTTAGCACTTTGACATGTCTTGGGGAAAAGCTTACATTTTAATTTAAA AGAAAGATCAATTATATCCATGCTTAACAGGATCAGCAGGAGCTTTATAAATGACTTTACAGAGACTAATAAGGGATTTGATCTTTCTTT TTTTGTTATCGAGGCTTTTGAAATGTGGAACTTGTGTGTTCTGCTTTATATGTTATATTCAATATCTTTTCAGATGCAGTCTATATTTTA TGCTGAGTTTTAAAAATGAAATACTTTATGCAAACAGGCAAAATTGGTACCAAAGGGAAACATTAACCATGAGGAAGAGCATTTTTCTAA GGAGAACAGGTGACAATATACACATGTGCGCTAATCGTAAAATGAGCATCTTAGTCTTTAAAACACATCAGAATTGAATACGAATAATCT ATTTGTCGATGAAATAAACACAACTCTTTGAGGATTTGAGACTACATTCACCCTTTATTCACAGTCACTTGCAGTTTTGCTTTTCTCTGC ATTTCTCTGCTGTAAGATGACTGTTGCATTGTTGAATTGTATTTTGAGTGGATATTTTTGTTTGGTAACAATTAAAATTTTAAATCGTAA >In-frame_IGF2R_ENST00000356956_chr6_160431817_+_SLC22A3_ENST00000392145_chr6_160819011_+_5832nt CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTTT GAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTGC CTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCTG CAAGAAAGACATATTTAAAGCAAATAAGGAGTTTGACCTTGTCTGTGTCAATGCGTGGATGCTGGACCTCACCCAAGCCATCCTGAACCT CGGCTTCCTGACTGGAGCATTCACCTTAGGCTATGCAGCAGACAGGTATGGCAGGATCGTCATTTACTTGCTATCCTGCCTTGGTGTTGG CGTCACTGGGGTTGTGGTGGCCTTTGCACCAAACTTCCCTGTGTTTGTGATCTTCCGCTTCCTGCAAGGTGTATTTGGAAAGGGGACGTG GATGACTTGCTACGTGATTGTGACAGAAATAGTAGGTTCGAAACAAAGGAGGATTGTGGGAATCGTGATTCAAATGTTCTTTACCCTTGG AATCATAATTCTCCCTGGAATTGCCTACTTCATCCCCAACTGGCAAGGAATCCAGTTAGCCATCACGCTGCCCAGCTTTCTCTTCCTCCT TTATTACTGGGTGGTCCCTGAGTCTCCCCGTTGGCTGATTACTCGGAAGAAAGGAGATAAAGCATTACAGATCCTGAGACGCATTGCTAA GTGCAATGGGAAATACCTCTCATCAAATTACTCAGAGATCACTGTTACAGATGAGGAAGTTAGTAATCCATCCTTTTTAGATCTGGTGAG AACTCCCCAAATGAGGAAATGCACACTTATTCTTATGTTTGCTTGGTTCACAAGCGCAGTGGTGTATCAAGGACTTGTCATGCGCCTGGG AATTATAGGGGGCAACCTCTATATAGACTTTTTCATCTCGGGCGTGGTGGAACTGCCAGGAGCTCTCTTGATCTTACTAACCATTGAGCG CCTTGGACGACGCCTCCCCTTTGCGGCAAGCAATATAGTGGCAGGGGTGGCATGCCTTGTCACTGCGTTCTTACCAGAAGCAGGAATAGC ATGGTTGAGGACCACAGTGGCTACATTGGGAAGACTAGGGATAACCATGGCCTTTGAAATTGTTTATTTGGTAAATTCAGAATTGTACCC AACAACATTACGAAATTTCGGAGTTTCGCTCTGTTCAGGTCTGTGTGATTTTGGGGGAATCATAGCCCCATTTCTGCTCTTTCGGCTAGC AGCCGTGTGGCTAGAACTACCTCTGATCATCTTTGGTATCCTGGCATCCATCTGTGGTGGCCTTGTGATGCTTTTGCCTGAAACCAAGGG TATTGCCTTGCCAGAGACAGTGGATGATGTAGAAAAACTTGGCAGTCCACATTCCTGTAAATGTGGCAGGAATAAGAAAACCCCAGTTTC CCGCTCTCACCTTTGAGGCCCCCGACAAAGACAGAAAGAAGGAGCTATCCAGGAGCTGATCCTCCTTGCAAAGCTGTGCCTTGCAGAGAT GCACGTGTGCATTTCAGCTACATCATGCCGCGCTGTTGTAATACTGTATAAAGACCTCAATCTATCCAGAGTATTTTTATATAATGTTGG ATGAGTTAGGATTTGTAATGCTGTTGAAGTTTCTGGGAACACATAATATGTAGCCAGTTTAACAAAGAAGCTGTCAGGTGCACAGCCCTT CCTGGGTTTTTTTCTTGTGTTCCCTGTGGTCTCTGACCCATTAGGCTAAAGAGAGACAAGAGAAGCCCCCAACCTGATTCTCATGACAGC TCCATCAAGAATGTGGGATGTGCCGACCAAGGATTTGAGAAAGTTGTACAGAAATGTGTTCATCAAATCTGGTCAAGGGACTAAGCTCCT AGCTGACCATTCATTCTGAAGATTGCATGGAGGATGAACATCTGGGAATCCTGTTAATGAGAAGGCTGAATCACAGGCACCTGGGCCAAA GGGTGTGAGCATTCATGTTCTCTGCTCACCTTGGTTTCCGCACACCTTCGCAATGTGAACAGGTCAGGAGTCCCTCCCGTCCACCTCCTC TGTAACAGCTGGGGTTCCAGGCATGGTTTAGGCCCTGTTCCAGCAATAAGAACCAATCTGCTGTACAATCTGAGGACTTGGCTCTGTTAT TTACAAAATGATGCTGTGGTTCTGAGATTATTTGGGACATTTTTGGCTCTCCTTTAGTGGACACCTAGAGCCACAGATTCCCTTCTTTAC TAAACAAATCCCATGGATTCTGATTTCTGGGTCTTAGGATTTTAAAAGTGAAGGGATATTTTTCTTATATTTGTGAGTTCAGTTCCGATG GTGCCCGTGGTCAAAAGCGAAAAACATGGACAATTCCTATTCATTCTTAGCACTTTGACATGTCTTGGGGAAAAGCTTACATTTTAATTT AAAAGAAAGATCAATTATATCCATGCTTAACAGGATCAGCAGGAGCTTTATAAATGACTTTACAGAGACTAATAAGGGATTTGATCTTTC TTTTTTTGTTATCGAGGCTTTTGAAATGTGGAACTTGTGTGTTCTGCTTTATATGTTATATTCAATATCTTTTCAGATGCAGTCTATATT TTATGCTGAGTTTTAAAAATGAAATACTTTATGCAAACAGGCAAAATTGGTACCAAAGGGAAACATTAACCATGAGGAAGAGCATTTTTC TAAGGAGAACAGGTGACAATATACACATGTGCGCTAATCGTAAAATGAGCATCTTAGTCTTTAAAACACATCAGAATTGAATACGAATAA TCTATTTGTCGATGAAATAAACACAACTCTTTGAGGATTTGAGACTACATTCACCCTTTATTCACAGTCACTTGCAGTTTTGCTTTTCTC TGCATTTCTCTGCTGTAAGATGACTGTTGCATTGTTGAATTGTATTTTGAGTGGATATTTTTGTTTGGTAACAATTAAAATTTTAAATCG TAAAAAATGTACATTTGCCCTTTCTCTTCCTTCTAAACATGTGTCTCTCCCACAGGTCATTCTCCTGTGACACGTGTACTGCAGAGTGTT TCAAAACCGGGCAGGCAATTAGCAATGGGAAATAAGTGGTCCACCTTCAATATTTGCTTGTTGTTCATTTACATGCTCTTGGCACCAATC CTAGACTCACGTGTGCCCCAGAATAACATTCAGACTCTCAGCTGGTCTTGTGTTACACATCCATGGACCGGTTCACTCCATCATATACAG CTCTCTGCTCCGTGTCCCCTGGGCTCAAGTCAAGCAGTCGGTGACAGATTTCATTCCCAATAACAGAATCGGTTTGCATGACTCCCCATA CATGTTGCAGCTTTGAAAACATTCATCTCAGAGTTAGGTATAAAGACATAAAAATGTGTGTCAAGCCCTCGTTAGCTGATGAGGTAAATG CATGGACAACTTCCTAGGACTTCTCGGCTCTGCCCTCTGTGACCTTGCAGCCTGCTCAGGTCTTTGTGCTCTGTTCCTTATCAAAAACAG CACAACCCCCTCAATCTGCCCATTTAAAAATTGGTGGAGTGAACAAAGAGCATGAAAATGTTGAAGACCACAACCAAAATTTACTCAAAT CAAAGTTAAGTACAGAGTTTATTTTTAACAAATGTCATAGCTATGTCACCTTACTACAGAATCCAGCAGTCAGAAAATAACACAAAAAAT GCCGAGGTTTGGCGTAGCTGGTAGCTGGGGACAGTGTCTTCGTTTGATTACTGCCAGTTATTTCCAGCATGCTAAATCCCTACCCACGTT CCAGCCTCTAGGTGAGTCAGTGCGTCACTCTGTCTCCCGTCCAATTAATTATTTCTCATCACTCCCTCAATCCAAGTAACAAACCTTGAA ACACGAACATAGACACCAGGCTTATTGGGGCGTGCACAGCCAAGACCCCAAGAAGTGACTCCTTGTAAAATGTATTTGTCCTTCTCAAAG CAAACCAGAGGCCCTCCACTGTCACCCTAAATAGAGGTAGGGAAAAATTCATGTGAGGGTTAGGCTGCCAGCCTTTTATTGTGGCATCCA TCTATTGTCCATATGTATATTTTCCCAGTAATTGAAATTGGAAAGGAACTTATGGGCATATTACTGGAGCATCTGCAGTGCTTAAGTACT TAGCAAAATCTATTCAGCGAAACCACACCACTTAGTTTCTCCCAGGGGTAAAAAAAACCCTTGTGAATCCTGCACACATCCCTTCCTGTG TTGGTGTTTCCTTTAGACTGGCCTAGCCTGGGCATCACTGTAAAGTATGTGCAGTTGGTCTCTGTCCTGTACCCTCTACCTCCTTCCCTG TCGGAAAAGTCACCACTTTAGTCCCTGGCCACCAGCACACCCCAGGAGGGTGAGTGGCCTGAGGTAGTTACGGCACTTAAAACTCCCTTG CTACCGATCTGGAACTCAAGCCCCAAGACATCCCCTTAGATGATCTGAATACGCATTCAGGGACAGATCTAGGCAGTTTCTAAACAACAC TTAGACTGGGGTCTAACGTTGACAAATCCTTCTAGAATTTGCCTCTTTGGGACTGAAGTCTAAGGGGCTGAGACCAAGAAGGGAGAGCAC AAGACTAACTTTGGTCTCTTGACCTTTTCTTACCTTGCAACTGTCAGTGCCTCCAGCCAAATGCCTAGCACAGAGCTCAGTGGATTTGAT TCTTCCATTCAGATACTCATAGCGATTGCACACTTTATTCTCAATCACAAGAAGCTGGGGCTTCCTTGAGAAGGCCAGCCCCAAAGGTAC CTGTGTTTAAAAGATGAAAGAAATGGTTGCTGAACCCAAAACATGTTTAGGAGGAAAACCAGAAGAACAGAGCAGTGGCACTGGACCTCC TGTCTGTCCGTGAGGCTGCAGAACACAAGGCAGCTCCCAATGCCGCTGGACTCTCTGACCTTGGAGAGTGTAAACATCATATATGATTCT GTGTTCCTGAGATCTGGGTTTAACGATCTGGGCTTTGTCATGGTGTTTTACGTTCGTTGTTGTTTGTGTACTTTTTGCTTTTCTTTTGAA AGTATGAAAATGATTTTTACAATGTAAAGAGAGTCTGAGAAATGCAATTGCTATTCTTTTTATATACTTTTTCAGATTTTTTATATGCTT CTTTACTACTTACATCATAATGCACAATTTTATATACTGATTTTTTCAATCAATGTATATCATGAGTTTTTAAAATAATGCTACAATCTT CATAACTAATATTTTAATGGGGAGTGACTGCTTAATTGGCATGAGGTTTCCTTTTGAGATGAGGAAAATGTTCTGAAAATATGGTGATGG |
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FusionGenePPI for IGF2R_SLC22A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IGF2R | CREG1, PLIN3, PLAUR, USP50, ELAVL1, MYC, SIRT7, GGA2, GGA3, GGA1, CSNK2A1, FBXO6, TM9SF4, COA7, SERINC1, TIMM10B, ATXN1, FN1, CCDC8, ABCE1, EWSR1, TMEM17, TMEM216, RAB5C, XRCC5, GTSE1, CHMP4B, CDH1, PPM1H, NCDN, TRIM25 | SLC22A3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGF2R_SLC22A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IGF2R | P11717 | DB01277 | Mecasermin | Cation-independent mannose-6-phosphate receptor | biotech | approved|investigational |
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RelatedDiseases for IGF2R_SLC22A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IGF2R | C0024115 | Lung diseases | 2 | CTD_human |
| Hgene | IGF2R | C0235833 | Congenital diaphragmatic hernia | 2 | CTD_human |
| Hgene | IGF2R | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Hgene | IGF2R | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | IGF2R | C0030567 | Parkinson Disease | 1 | CTD_human |
| Hgene | IGF2R | C0752347 | Lewy Body Disease | 1 | CTD_human |
| Hgene | IGF2R | C2239176 | Liver carcinoma | 1 | CTD_human;HPO |
| Tgene | SLC22A3 | C0010246 | Coxsackievirus Infections | 1 | CTD_human |
| Tgene | SLC22A3 | C0027059 | Myocarditis | 1 | CTD_human |
| Tgene | SLC22A3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | SLC22A3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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