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Fusion gene ID: 17158 |
FusionGeneSummary for IGF2BP3_ACSM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGF2BP3_ACSM1 | Fusion gene ID: 17158 | Hgene | Tgene | Gene symbol | IGF2BP3 | ACSM1 | Gene ID | 10643 | 116285 |
| Gene name | insulin like growth factor 2 mRNA binding protein 3 | acyl-CoA synthetase medium chain family member 1 | |
| Synonyms | CT98|IMP-3|IMP3|KOC|KOC1|VICKZ3 | BUCS1|MACS1 | |
| Cytomap | 7p15.3 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor 2 mRNA-binding protein 3IGF-II mRNA-binding protein 3IGF2 mRNA-binding protein 3KH domain containing protein overexpressed in cancerVICKZ family member 3cancer/testis antigen 98 | acyl-coenzyme A synthetase ACSM1, mitochondrialButyrate CoA ligasebutyrate--CoA ligase 1butyryl Coenzyme A synthetase 1butyryl-coenzyme A synthetase 1lipoate-activating enzymemedium-chain acyl-CoA synthetasemiddle-chain acyl-CoA synthetase 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O00425 | Q08AH1 | |
| Ensembl transtripts involved in fusion gene | ENST00000258729, ENST00000491719, | ENST00000219151, ENST00000307493, ENST00000520010, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 5 X 5 X 4=100 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IGF2BP3 [Title/Abstract] AND ACSM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A124-01A | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000258729 | ENST00000219151 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| 5CDS-5UTR | ENST00000258729 | ENST00000307493 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| 5CDS-5UTR | ENST00000258729 | ENST00000520010 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| intron-5UTR | ENST00000491719 | ENST00000219151 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| intron-5UTR | ENST00000491719 | ENST00000307493 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
| intron-5UTR | ENST00000491719 | ENST00000520010 | IGF2BP3 | chr7 | 23390924 | - | ACSM1 | chr16 | 20682993 | - |
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FusionProtFeatures for IGF2BP3_ACSM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGF2BP3 | ACSM1 |
| RNA-binding factor that may recruit target transcriptsto cytoplasmic protein-RNA complexes (mRNPs). This transcript'caging' into mRNPs allows mRNA transport and transient storage.It also modulates the rate and location at which targettranscripts encounter the translational apparatus and shields themfrom endonuclease attacks or microRNA-mediated degradation. Bindsto the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes celladhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of theinsulin-like growth factor 2 (IGF2) mRNAs.{ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942}. | Has medium-chain fatty acid:CoA ligase activity withbroad substrate specificity (in vitro). Acts on acids from C(4) toC(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). Functions as GTP-dependent lipoate-activating enzyme that generates the substrate forlipoyltransferase (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IGF2BP3_ACSM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IGF2BP3_ACSM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IGF2BP3 | PUF60, CNBP, HNRNPA1, MEPCE, KHDRBS2, UBC, ELAVL1, SIRT7, CUL3, CDK2, COPS5, CAND1, RAE1, DDX5, LAPTM4A, LGMN, HNRNPUL2, USP16, NDUFAF4, MYC, FN1, CBX6, CBX8, HDAC11, FBXO6, CRYZ, HNRNPA2B1, HNRNPM, HNRNPU, IARS, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, EDC4, EIF2B2, EIF2B3, EPRS, FKBP3, FLII, ILF2, MAP2, NMT1, QARS, RFC4, RPL26L1, RPL38, KRT17, MRE11A, PA2G4, RPL23A, WWOX, EIF2AK2, LIN28A, STAU1, MDM2, AURKA, TP53, TUBGCP3, MEOX2, PIH1D2, MOV10, CUL7, OBSL1, CCDC8, NTRK1, G3BP2, IGF2BP1, PDCD6, RPL6, RAB2A, RPL37A, MED20, NPM1, ZNF746, SH3BGR, ELAVL2, GSPT2, MRPS34, HIST1H1E, APOBEC3D, PPAN, RBM3, TRIM25, G3BP1, BRCA1 | ACSM1 | APBA3, SLC22A16, GBP5, PRC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IGF2BP3_ACSM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IGF2BP3_ACSM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IGF2BP3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | IGF2BP3 | C0031149 | Peritoneal Neoplasms | 1 | CTD_human |
| Hgene | IGF2BP3 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | ACSM1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | ACSM1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | ACSM1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | ACSM1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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