![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 17129 |
FusionGeneSummary for IFT88_FAM114A1 |
![]() |
Fusion gene information | Fusion gene name: IFT88_FAM114A1 | Fusion gene ID: 17129 | Hgene | Tgene | Gene symbol | IFT88 | FAM114A1 | Gene ID | 8100 | 92689 |
Gene name | intraflagellar transport 88 | family with sequence similarity 114 member A1 | |
Synonyms | D13S1056E|DAF19|TG737|TTC10|hTg737 | Noxp20 | |
Cytomap | 13q12.11 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | intraflagellar transport protein 88 homologTPR repeat protein 10intraflagellar transport 88 homologpolaris homologprobe hTg737 (polycystic kidney disease, autosomal recessive)recessive polycystic kidney disease protein Tg737 homologtesticular tissue | protein NOXP20nervous system over-expressed protein 20 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q13099 | Q8IWE2 | |
Ensembl transtripts involved in fusion gene | ENST00000382778, ENST00000351808, ENST00000319980, ENST00000537103, ENST00000461115, | ENST00000515037, ENST00000358869, ENST00000513966, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 3 X 4=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IFT88 [Title/Abstract] AND FAM114A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-HB-A3L4-01A | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000382778 | ENST00000515037 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000382778 | ENST00000358869 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-intron | ENST00000382778 | ENST00000513966 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000351808 | ENST00000515037 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000351808 | ENST00000358869 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-intron | ENST00000351808 | ENST00000513966 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000319980 | ENST00000515037 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000319980 | ENST00000358869 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-intron | ENST00000319980 | ENST00000513966 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000537103 | ENST00000515037 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-5UTR | ENST00000537103 | ENST00000358869 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
5CDS-intron | ENST00000537103 | ENST00000513966 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
intron-5UTR | ENST00000461115 | ENST00000515037 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
intron-5UTR | ENST00000461115 | ENST00000358869 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
intron-intron | ENST00000461115 | ENST00000513966 | IFT88 | chr13 | 21157158 | + | FAM114A1 | chr4 | 38907143 | + |
Top |
FusionProtFeatures for IFT88_FAM114A1 |
![]() |
Hgene | Tgene |
IFT88 | FAM114A1 |
Involved in primary cilium biogenesis. Also involved inautophagy since it is required for trafficking of ATG16L and theexpansion of the autophagic compartment.{ECO:0000250|UniProtKB:Q61371}. | May play a role in neuronal cell development.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for IFT88_FAM114A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for IFT88_FAM114A1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IFT88 | PRRC2A, IFT81, IFT46, IFT57, CCDC151, IFT80, LCA5, CSNK2A2, ZWINT, CDKN2AIP, SMC6, UBXN10, VCP, TTC30A, TTC30B, FGF8, IFT172, IFT20, IFT74, IFT27, TRAF3IP1, CLUAP1, HSPB11, TTC26, IFT22, IFT52, ICK | FAM114A1 | AKT1S1, FAF1, PPAT, TLN1, HSPA4, N4BP1, RSU1, SEC24D, TARS, THUMPD3, RAB2A, SPG21, AGTRAP, RAB2B, CMTM5, TENC1, MIRLET7A1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for IFT88_FAM114A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for IFT88_FAM114A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IFT88 | C0085548 | Autosomal Recessive Polycystic Kidney Disease | 2 | CTD_human |
Hgene | IFT88 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | IFT88 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | IFT88 | C0152427 | Polydactyly | 1 | CTD_human |