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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 17117

FusionGeneSummary for IFT74_WNK2

check button Fusion gene summary
Fusion gene informationFusion gene name: IFT74_WNK2
Fusion gene ID: 17117
HgeneTgene
Gene symbol

IFT74

WNK2

Gene ID

80173

65268

Gene nameintraflagellar transport 74WNK lysine deficient protein kinase 2
SynonymsBBS20|CCDC2|CMG-1|CMG1NY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43
Cytomap

9p21.2

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 74 homologcapillary morphogenesis gene 1 proteincapillary morphogenesis protein 1coiled-coil domain containing 2coiled-coil domain-containing protein 2intraflagellar transport 74 homologserine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43
Modification date2018052320180523
UniProtAcc

Q96LB3

Q9Y3S1

Ensembl transtripts involved in fusion geneENST00000433700, ENST00000443698, 
ENST00000380062, ENST00000429045, 
ENST00000427277, ENST00000297954, 
ENST00000395475, ENST00000356055, 
ENST00000349097, ENST00000395477, 
ENST00000471076, 
Fusion gene scores* DoF score4 X 2 X 4=327 X 7 X 7=343
# samples 47
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/343*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFT74 [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWNK2

GO:0006468

protein phosphorylation

21733846

TgeneWNK2

GO:0046777

protein autophosphorylation

17667937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2759-01AIFT74chr9

26962085

+WNK2chr9

96079802

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000433700ENST00000427277IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000433700ENST00000297954IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000433700ENST00000395475IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000433700ENST00000356055IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000433700ENST00000349097IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000433700ENST00000395477IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000433700ENST00000471076IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000443698ENST00000427277IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000443698ENST00000297954IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000443698ENST00000395475IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000443698ENST00000356055IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000443698ENST00000349097IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000443698ENST00000395477IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000443698ENST00000471076IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000380062ENST00000427277IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000380062ENST00000297954IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000380062ENST00000395475IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000380062ENST00000356055IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000380062ENST00000349097IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000380062ENST00000395477IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000380062ENST00000471076IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000429045ENST00000427277IFT74chr9

26962085

+WNK2chr9

96079802

+
In-frameENST00000429045ENST00000297954IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000429045ENST00000395475IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000429045ENST00000356055IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000429045ENST00000349097IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000429045ENST00000395477IFT74chr9

26962085

+WNK2chr9

96079802

+
5CDS-3UTRENST00000429045ENST00000471076IFT74chr9

26962085

+WNK2chr9

96079802

+

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FusionProtFeatures for IFT74_WNK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFT74

Q96LB3

WNK2

Q9Y3S1

Component of the intraflagellar transport (IFT) complexB: together with IFT81, forms a tubulin-binding module thatspecifically mediates transport of tubulin within the cilium.Binds beta-tubulin via its basic region. Required forciliogenesis. {ECO:0000269|PubMed:23990561}. Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival, and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SLC12A2, SCNN1A,SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulatesthe EGF-induced activation of the ERK/MAPK-pathway and thedownstream cell cycle progression. Affects MAPK3/MAPK1 activity bymodulating the activity of MAP2K1 and this modulation depends onphosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering withthe activity of PAK1 by controlling the balance of the activity ofupstream regulators of PAK1 activity, RHOA and RAC1, which displayreciprocal activity. {ECO:0000269|PubMed:17667937,ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT74chr9:26962085chr9:96079802ENST00000380062+22098_48240601Coiled coilOntology_term=ECO:0000255
HgeneIFT74chr9:26962085chr9:96079802ENST00000429045+21498_48240373Coiled coilOntology_term=ECO:0000255
HgeneIFT74chr9:26962085chr9:96079802ENST00000433700+22098_48240601Coiled coilOntology_term=ECO:0000255
HgeneIFT74chr9:26962085chr9:96079802ENST00000443698+22098_48240601Coiled coilOntology_term=ECO:0000255
HgeneIFT74chr9:26962085chr9:96079802ENST00000380062+2201_9040601RegionNote=Basic region
HgeneIFT74chr9:26962085chr9:96079802ENST00000429045+2141_9040373RegionNote=Basic region
HgeneIFT74chr9:26962085chr9:96079802ENST00000433700+2201_9040601RegionNote=Basic region
HgeneIFT74chr9:26962085chr9:96079802ENST00000443698+2201_9040601RegionNote=Basic region
TgeneWNK2chr9:26962085chr9:96079802ENST00000297954+2730195_45322092298DomainProtein kinase
TgeneWNK2chr9:26962085chr9:96079802ENST00000297954+2730275_27822092298Nucleotide bindingATP


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FusionGeneSequence for IFT74_WNK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_93aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTS

>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_129aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVW

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_93aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTS

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_129aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVW

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_93aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTS

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_129aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVW

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_93aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPGSCGPRAVSTPTS

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_129aa
MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_279nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCC

>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_387nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGG
TTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTT

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_279nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCC

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_387nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGG
TTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTT

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_279nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCC

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_387nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGG
TTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTT

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_279nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCC

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_387nt
ATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCC
CTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTG
TCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGG
TTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_406nt
TCGTCATGGCCAGTGTCTGTCTGGCGCCCGGTGCCCAGGCACTGTGCGAGACCAGTCCGCAGGGGCGACTCGGAGAGCGCCGGGCCGCGG
CGGGAGAAGAGCCTGCAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGT
TGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGT
GGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGG

>In-frame_IFT74_ENST00000433700_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_758nt
TCGTCATGGCCAGTGTCTGTCTGGCGCCCGGTGCCCAGGCACTGTGCGAGACCAGTCCGCAGGGGCGACTCGGAGAGCGCCGGGCCGCGG
CGGGAGAAGAGCCTGCAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGT
TGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGT
GGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGA
TGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCG
AGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGTTCGCTCCTAGGTTCCTGTGGTCCACGCGCCGTCTCC
ACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCACCCTGCAGAAGTACAGTGCCTTGAATGCCAGCTTTTCCGTTCCC
TGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTTGCAATTGGCTTGTGCATTGATAATCTTTATTTACTGTTTTAAGT

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_450nt
GACGCCGATGCGGAGCTGAGCTGGCTTTCCTCCAGGGCTCTGGACTCCCTGCTGAGCAAGAGAGAAAGAGGCCCGCCCTTCCACCAGGAC
GCCTGACCCTGGGGTCCTTCCCAAACCCGGGTCTCTTCCGACTCCGGGCCCAACAGTTTGTGCGATTAAAGTGAAGAAACAATGGCCAGC
AATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGA
AATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACG
GTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGA

>In-frame_IFT74_ENST00000443698_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_802nt
GACGCCGATGCGGAGCTGAGCTGGCTTTCCTCCAGGGCTCTGGACTCCCTGCTGAGCAAGAGAGAAAGAGGCCCGCCCTTCCACCAGGAC
GCCTGACCCTGGGGTCCTTCCCAAACCCGGGTCTCTTCCGACTCCGGGCCCAACAGTTTGTGCGATTAAAGTGAAGAAACAATGGCCAGC
AATCACAAATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGA
AATATTCGAGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACG
GTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTC
CGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCA
GACCCTGTTCGCTCCTAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCA
CCCTGCAGAAGTACAGTGCCTTGAATGCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTT

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_442nt
ATCCCGCCCCCGTTGCCGGGATACGCCGCGGCGCACGGCAGTTAGTGGGTAGGCCTGAGAGCCGAGGAAAACTGAGCGTGGGCCTCAGAA
AGAAGTTAAGGCACCCGCGAGCCGGGCAACTGCCCTCCTTCCGCGCCGGCGGAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAA
ATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCG
AGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCC

>In-frame_IFT74_ENST00000380062_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_794nt
ATCCCGCCCCCGTTGCCGGGATACGCCGCGGCGCACGGCAGTTAGTGGGTAGGCCTGAGAGCCGAGGAAAACTGAGCGTGGGCCTCAGAA
AGAAGTTAAGGCACCCGCGAGCCGGGCAACTGCCCTCCTTCCGCGCCGGCGGAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAA
ATCTTCAGCAGCTCGCCCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCG
AGTGGCAACTGCAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCC
CGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTCCC
CCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGT
TCGCTCCTAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCACCCTGCAG
AAGTACAGTGCCTTGAATGCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTTGCAATTGG

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000427277_chr9_96079802_+_336nt
GCGAGCCGGGCAACTGCCCTCCTTCCGCGCCGGCGGAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAAATCTTCAGCAGCTCGC
CCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCGAGTGGCAACTGCAATG
ACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACC

>In-frame_IFT74_ENST00000429045_chr9_26962085_+_WNK2_ENST00000297954_chr9_96079802_+_688nt
GCGAGCCGGGCAACTGCCCTCCTTCCGCGCCGGCGGAGCGATTAAAGTGAAGAAACAATGGCCAGCAATCACAAATCTTCAGCAGCTCGC
CCTGTTTCAAGAGGTGGAGTTGGGTTAACAGGAAGGCCTCCTTCTGGGATACGACCCCTATCAGGAAATATTCGAGTGGCAACTGCAATG
ACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACC
CTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGT
GGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGTTCGCTCCTAGGTTCCT
GTGGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCACCCTGCAGAAGTACAGTGCCTTGA
ATGCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTTGCAATTGGCTTGTGCATTGATAAT


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FusionGenePPI for IFT74_WNK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IFT74ELAVL1, ANKRD55, IFT57, CCDC151, ARL13B, IFT81, C17orf59, MED4, LCA5, SSX2IP, OFD1, PCM1, CEP170, CEP162, CEP128, CEP135, CEP63, FBF1, NINL, ODF2, RPGRIP1L, RPGRIP1, GLI1, UBXN10, VCP, UFD1L, NPLOC4, TTC30A, SIGLEC7, TTC30B, TSPYL4, JPH4, FGF8, KNSTRN, IFT22, IFT46, IFT52, LRRFIP1, TXLNA, SERPINB2, RHPN1, CREB1, HSPB11, IFT88, IFT27, TTC26, IFT80, IFT172, TRAF3IP1, IFT20, CCDC28BWNK2YWHAZ, WNK1, SGK1, ATXN1, KLHL3, KLHL2, DGCR14, TSC22D4, PSMC3, SPATA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IFT74_WNK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IFT74_WNK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource