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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17066

FusionGeneSummary for IFI6_SERINC1

check button Fusion gene summary
Fusion gene informationFusion gene name: IFI6_SERINC1
Fusion gene ID: 17066
HgeneTgene
Gene symbol

IFI6

SERINC1

Gene ID

2537

57515

Gene nameinterferon alpha inducible protein 6serine incorporator 1
Synonyms6-16|FAM14C|G1P3|IFI-6-16|IFI616TDE1L|TDE2|TMS-2|TMS2
Cytomap

1p35.3

6q22.31

Type of geneprotein-codingprotein-coding
Descriptioninterferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16serine incorporator 1tumor differentially expressed protein 2
Modification date2018052320180523
UniProtAcc

P09912

Q9NRX5

Ensembl transtripts involved in fusion geneENST00000361157, ENST00000339145, 
ENST00000362020, 
ENST00000339697, 
Fusion gene scores* DoF score6 X 5 X 2=608 X 9 X 4=288
# samples 610
** MAII scorelog2(6/60*10)=0log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFI6 [Title/Abstract] AND SERINC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF576882IFI6chr1

27993894

-SERINC1chr6

122765252

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000361157ENST00000339697IFI6chr1

27993894

-SERINC1chr6

122765252

-
intron-3UTRENST00000339145ENST00000339697IFI6chr1

27993894

-SERINC1chr6

122765252

-
intron-3UTRENST00000362020ENST00000339697IFI6chr1

27993894

-SERINC1chr6

122765252

-

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FusionProtFeatures for IFI6_SERINC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFI6

P09912

SERINC1

Q9NRX5

Enhances the incorporation of serine intophosphatidylserine and sphingolipids.{ECO:0000250|UniProtKB:Q7TNK0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IFI6_SERINC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IFI6_SERINC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IFI6_SERINC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IFI6_SERINC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIFI6C0000786Spontaneous abortion1CTD_human
HgeneIFI6C0021400Influenza1CTD_human