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Fusion gene ID: 17066 |
FusionGeneSummary for IFI6_SERINC1 |
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Fusion gene information | Fusion gene name: IFI6_SERINC1 | Fusion gene ID: 17066 | Hgene | Tgene | Gene symbol | IFI6 | SERINC1 | Gene ID | 2537 | 57515 |
Gene name | interferon alpha inducible protein 6 | serine incorporator 1 | |
Synonyms | 6-16|FAM14C|G1P3|IFI-6-16|IFI616 | TDE1L|TDE2|TMS-2|TMS2 | |
Cytomap | 1p35.3 | 6q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | interferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16 | serine incorporator 1tumor differentially expressed protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P09912 | Q9NRX5 | |
Ensembl transtripts involved in fusion gene | ENST00000361157, ENST00000339145, ENST00000362020, | ENST00000339697, | |
Fusion gene scores | * DoF score | 6 X 5 X 2=60 | 8 X 9 X 4=288 |
# samples | 6 | 10 | |
** MAII score | log2(6/60*10)=0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IFI6 [Title/Abstract] AND SERINC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF576882 | IFI6 | chr1 | 27993894 | - | SERINC1 | chr6 | 122765252 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000361157 | ENST00000339697 | IFI6 | chr1 | 27993894 | - | SERINC1 | chr6 | 122765252 | - |
intron-3UTR | ENST00000339145 | ENST00000339697 | IFI6 | chr1 | 27993894 | - | SERINC1 | chr6 | 122765252 | - |
intron-3UTR | ENST00000362020 | ENST00000339697 | IFI6 | chr1 | 27993894 | - | SERINC1 | chr6 | 122765252 | - |
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FusionProtFeatures for IFI6_SERINC1 |
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Hgene | Tgene |
IFI6 | SERINC1 |
Enhances the incorporation of serine intophosphatidylserine and sphingolipids.{ECO:0000250|UniProtKB:Q7TNK0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IFI6_SERINC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IFI6_SERINC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IFI6_SERINC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFI6_SERINC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IFI6 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | IFI6 | C0021400 | Influenza | 1 | CTD_human |