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Fusion gene ID: 17065 |
FusionGeneSummary for IFI6_PRSS8 |
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Fusion gene information | Fusion gene name: IFI6_PRSS8 | Fusion gene ID: 17065 | Hgene | Tgene | Gene symbol | IFI6 | PRSS8 | Gene ID | 2537 | 5652 |
Gene name | interferon alpha inducible protein 6 | serine protease 8 | |
Synonyms | 6-16|FAM14C|G1P3|IFI-6-16|IFI616 | CAP1|PROSTASIN | |
Cytomap | 1p35.3 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | interferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16 | prostasinchannel-activating protease 1protease, serine 8 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P09912 | Q16651 | |
Ensembl transtripts involved in fusion gene | ENST00000361157, ENST00000339145, ENST00000362020, | ENST00000317508, ENST00000568261, | |
Fusion gene scores | * DoF score | 6 X 5 X 2=60 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/60*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: IFI6 [Title/Abstract] AND PRSS8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA193290 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000361157 | ENST00000317508 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
intron-3CDS | ENST00000361157 | ENST00000568261 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
intron-3CDS | ENST00000339145 | ENST00000317508 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
intron-3CDS | ENST00000339145 | ENST00000568261 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
intron-3CDS | ENST00000362020 | ENST00000317508 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
intron-3CDS | ENST00000362020 | ENST00000568261 | IFI6 | chr1 | 27992702 | + | PRSS8 | chr16 | 31144126 | + |
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FusionProtFeatures for IFI6_PRSS8 |
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Hgene | Tgene |
IFI6 | PRSS8 |
Possesses a trypsin-like cleavage specificity with apreference for poly-basic substrates. Stimulates epithelial sodiumchannel (ENaC) activity through activating cleavage of the gammasubunits (SCNN1G). {ECO:0000269|PubMed:15246975,ECO:0000269|PubMed:15474520}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IFI6_PRSS8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IFI6_PRSS8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IFI6_PRSS8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IFI6_PRSS8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IFI6 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | IFI6 | C0021400 | Influenza | 1 | CTD_human |
Tgene | PRSS8 | C0015929 | Fetal Diseases | 1 | CTD_human |
Tgene | PRSS8 | C0027794 | Neural Tube Defects | 1 | CTD_human |
Tgene | PRSS8 | C0032045 | Placenta Disorders | 1 | CTD_human |
Tgene | PRSS8 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | PRSS8 | C0037274 | Dermatologic disorders | 1 | CTD_human |