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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17062

FusionGeneSummary for IFI44L_SLC44A3

check button Fusion gene summary
Fusion gene informationFusion gene name: IFI44L_SLC44A3
Fusion gene ID: 17062
HgeneTgene
Gene symbol

IFI44L

SLC44A3

Gene ID

10964

126969

Gene nameinterferon induced protein 44 likesolute carrier family 44 member 3
SynonymsC1orf29|GS3686CTL3
Cytomap

1p31.1

1p21.3

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced protein 44-likecholine transporter-like protein 3
Modification date2018051920180519
UniProtAcc

Q53G44

Q8N4M1

Ensembl transtripts involved in fusion geneENST00000476521, ENST00000370751, 
ENST00000342282, 
ENST00000446120, 
ENST00000271227, ENST00000527077, 
ENST00000529450, ENST00000467909, 
ENST00000532427, ENST00000530397, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: IFI44L [Title/Abstract] AND SLC44A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIFI44L

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A2KD-01AIFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476521ENST00000446120IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3CDSENST00000476521ENST00000271227IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3CDSENST00000476521ENST00000527077IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3CDSENST00000476521ENST00000529450IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3CDSENST00000476521ENST00000467909IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3CDSENST00000476521ENST00000532427IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
3UTR-3UTRENST00000476521ENST00000530397IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000446120IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000271227IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000527077IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000529450IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000467909IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000370751ENST00000532427IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3UTRENST00000370751ENST00000530397IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000446120IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000271227IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000527077IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000529450IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000467909IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3CDSENST00000342282ENST00000532427IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+
5UTR-3UTRENST00000342282ENST00000530397IFI44Lchr1

79086256

+SLC44A3chr1

95322891

+

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FusionProtFeatures for IFI44L_SLC44A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFI44L

Q53G44

SLC44A3

Q8N4M1

Exhibits a low antiviral activity against hepatitis Cvirus. {ECO:0000269|PubMed:21478870}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IFI44L_SLC44A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IFI44L_SLC44A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IFI44LIFNA5, IFNA21SLC44A3FHL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IFI44L_SLC44A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IFI44L_SLC44A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIFI44LC0021400Influenza1CTD_human