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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17044

FusionGeneSummary for IDUA_IDUA

check button Fusion gene summary
Fusion gene informationFusion gene name: IDUA_IDUA
Fusion gene ID: 17044
HgeneTgene
Gene symbol

IDUA

IDUA

Gene ID

3425

3425

Gene nameiduronidase, alpha-L-iduronidase, alpha-L-
SynonymsIDA|MPS1IDA|MPS1
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-L-iduronidasealpha-L-iduronidase
Modification date2018052420180524
UniProtAcc

P35475

P35475

Ensembl transtripts involved in fusion geneENST00000247933, ENST00000453894, 
ENST00000509744, ENST00000514224, 
ENST00000247933, ENST00000453894, 
ENST00000509744, ENST00000514224, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IDUA [Title/Abstract] AND IDUA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIDUA

GO:0030209

dermatan sulfate catabolic process

24036510

TgeneIDUA

GO:0030209

dermatan sulfate catabolic process

24036510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW136332IDUAchr4

996572

-IDUAchr4

997882

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000247933ENST00000247933IDUAchr4

996572

-IDUAchr4

997882

-
Frame-shiftENST00000247933ENST00000453894IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000247933ENST00000509744IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000247933ENST00000514224IDUAchr4

996572

-IDUAchr4

997882

-
Frame-shiftENST00000453894ENST00000247933IDUAchr4

996572

-IDUAchr4

997882

-
Frame-shiftENST00000453894ENST00000453894IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000453894ENST00000509744IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000453894ENST00000514224IDUAchr4

996572

-IDUAchr4

997882

-
intron-3CDSENST00000509744ENST00000247933IDUAchr4

996572

-IDUAchr4

997882

-
intron-3CDSENST00000509744ENST00000453894IDUAchr4

996572

-IDUAchr4

997882

-
intron-intronENST00000509744ENST00000509744IDUAchr4

996572

-IDUAchr4

997882

-
intron-intronENST00000509744ENST00000514224IDUAchr4

996572

-IDUAchr4

997882

-
Frame-shiftENST00000514224ENST00000247933IDUAchr4

996572

-IDUAchr4

997882

-
Frame-shiftENST00000514224ENST00000453894IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000514224ENST00000509744IDUAchr4

996572

-IDUAchr4

997882

-
5CDS-intronENST00000514224ENST00000514224IDUAchr4

996572

-IDUAchr4

997882

-

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FusionProtFeatures for IDUA_IDUA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDUA

P35475

IDUA

P35475


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IDUA_IDUA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IDUA_IDUA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IDUA_IDUA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IDUA_IDUA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIDUAC0086431Hurler-Scheie Syndrome11ORPHANET;UNIPROT
HgeneIDUAC0086795Pfaundler-Hurler Syndrome9HPO;ORPHANET;UNIPROT
HgeneIDUAC0026708Mucopolysaccharidosis V8ORPHANET;UNIPROT
HgeneIDUAC0023786Mucopolysaccharidosis I5CTD_human
TgeneIDUAC0086431Hurler-Scheie Syndrome11ORPHANET;UNIPROT
TgeneIDUAC0086795Pfaundler-Hurler Syndrome9HPO;ORPHANET;UNIPROT
TgeneIDUAC0026708Mucopolysaccharidosis V8ORPHANET;UNIPROT
TgeneIDUAC0023786Mucopolysaccharidosis I5CTD_human