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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17034

FusionGeneSummary for IDO1_IPO4

check button Fusion gene summary
Fusion gene informationFusion gene name: IDO1_IPO4
Fusion gene ID: 17034
HgeneTgene
Gene symbol

IDO1

IPO4

Gene ID

3620

79711

Gene nameindoleamine 2,3-dioxygenase 1importin 4
SynonymsIDO|IDO-1|INDOImp4
Cytomap

8p11.21

14q12

Type of geneprotein-codingprotein-coding
Descriptionindoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenaseimportin-4imp4bimportin-4bran-binding protein 4ranBP4
Modification date2018051920180523
UniProtAcc

P14902

Q8TEX9

Ensembl transtripts involved in fusion geneENST00000522495, ENST00000518237, 
ENST00000354464, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: IDO1 [Title/Abstract] AND IPO4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIPO4

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneIPO4

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF917390IDO1chr8

39780127

+IPO4chr14

24658704

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000522495ENST00000354464IDO1chr8

39780127

+IPO4chr14

24658704

-
5CDS-intronENST00000518237ENST00000354464IDO1chr8

39780127

+IPO4chr14

24658704

-

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FusionProtFeatures for IDO1_IPO4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDO1

P14902

IPO4

Q8TEX9

Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in the peripheralimmune tolerance, contributing to maintain homeostasis bypreventing autoimmunity or immunopathology that would result fromuncontrolled and overreacting immune responses (PubMed:25691885).Tryptophan shortage inhibits T lymphocytes division andaccumulation of tryptophan catabolites induces T-cell apoptosisand differentiation of regulatory T-cells (PubMed:25691885). Actsas a suppressor of anti-tumor immunity (PubMed:23103127,PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits thegrowth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immunerejection (PubMed:25691885). {ECO:0000269|PubMed:14502282,ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127,ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}. Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of RPS3A. Invitro, mediates the nuclear import of human cytomegalovirus UL84by recognizing a non-classical NLS. {ECO:0000250,ECO:0000269|PubMed:11823430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IDO1_IPO4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IDO1_IPO4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IDO1_IPO4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIDO1P14902DB00435Nitric OxideIndoleamine 2,3-dioxygenase 1small moleculeapproved

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RelatedDiseases for IDO1_IPO4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIDO1C0011570Mental Depression4PSYGENET
HgeneIDO1C0011581Depressive disorder4PSYGENET
HgeneIDO1C0014175Endometriosis1CTD_human
HgeneIDO1C0021368Inflammation1CTD_human
HgeneIDO1C0027643Neoplasm Recurrence, Local1CTD_human
HgeneIDO1C0028754Obesity1CTD_human
HgeneIDO1C0043094Weight Gain1CTD_human
HgeneIDO1C0178417Anhedonia1PSYGENET
HgeneIDO1C0338715Drug-induced depressive state1PSYGENET
HgeneIDO1C0524851Neurodegenerative Disorders1CTD_human
HgeneIDO1C0581391Chronic depression1PSYGENET
HgeneIDO1C1458155Mammary Neoplasms1CTD_human