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Fusion gene ID: 17034 |
FusionGeneSummary for IDO1_IPO4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IDO1_IPO4 | Fusion gene ID: 17034 | Hgene | Tgene | Gene symbol | IDO1 | IPO4 | Gene ID | 3620 | 79711 |
| Gene name | indoleamine 2,3-dioxygenase 1 | importin 4 | |
| Synonyms | IDO|IDO-1|INDO | Imp4 | |
| Cytomap | 8p11.21 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | indoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase | importin-4imp4bimportin-4bran-binding protein 4ranBP4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P14902 | Q8TEX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000522495, ENST00000518237, | ENST00000354464, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: IDO1 [Title/Abstract] AND IPO4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IPO4 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | IPO4 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF917390 | IDO1 | chr8 | 39780127 | + | IPO4 | chr14 | 24658704 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000522495 | ENST00000354464 | IDO1 | chr8 | 39780127 | + | IPO4 | chr14 | 24658704 | - |
| 5CDS-intron | ENST00000518237 | ENST00000354464 | IDO1 | chr8 | 39780127 | + | IPO4 | chr14 | 24658704 | - |
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FusionProtFeatures for IDO1_IPO4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IDO1 | IPO4 |
| Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in the peripheralimmune tolerance, contributing to maintain homeostasis bypreventing autoimmunity or immunopathology that would result fromuncontrolled and overreacting immune responses (PubMed:25691885).Tryptophan shortage inhibits T lymphocytes division andaccumulation of tryptophan catabolites induces T-cell apoptosisand differentiation of regulatory T-cells (PubMed:25691885). Actsas a suppressor of anti-tumor immunity (PubMed:23103127,PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits thegrowth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immunerejection (PubMed:25691885). {ECO:0000269|PubMed:14502282,ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127,ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}. | Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of RPS3A. Invitro, mediates the nuclear import of human cytomegalovirus UL84by recognizing a non-classical NLS. {ECO:0000250,ECO:0000269|PubMed:11823430}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IDO1_IPO4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IDO1_IPO4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IDO1_IPO4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IDO1 | P14902 | DB00435 | Nitric Oxide | Indoleamine 2,3-dioxygenase 1 | small molecule | approved |
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RelatedDiseases for IDO1_IPO4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IDO1 | C0011570 | Mental Depression | 4 | PSYGENET |
| Hgene | IDO1 | C0011581 | Depressive disorder | 4 | PSYGENET |
| Hgene | IDO1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | IDO1 | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | IDO1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Hgene | IDO1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | IDO1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | IDO1 | C0178417 | Anhedonia | 1 | PSYGENET |
| Hgene | IDO1 | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
| Hgene | IDO1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Hgene | IDO1 | C0581391 | Chronic depression | 1 | PSYGENET |
| Hgene | IDO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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