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Fusion gene ID: 17026 |
FusionGeneSummary for IDH3A_SH2D7 |
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Fusion gene information | Fusion gene name: IDH3A_SH2D7 | Fusion gene ID: 17026 | Hgene | Tgene | Gene symbol | IDH3A | SH2D7 | Gene ID | 3419 | 646892 |
Gene name | isocitrate dehydrogenase 3 (NAD(+)) alpha | SH2 domain containing 7 | |
Synonyms | - | - | |
Cytomap | 15q25.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NA | SH2 domain-containing protein 7Putative SH2 domain-containing protein LOC646892hCG38941 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P50213 | A6NKC9 | |
Ensembl transtripts involved in fusion gene | ENST00000299518, ENST00000558554, ENST00000559205, ENST00000441490, ENST00000558535, ENST00000561366, | ENST00000409568, ENST00000328828, | |
Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: IDH3A [Title/Abstract] AND SH2D7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-CR-7380-01A | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000299518 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5CDS-5UTR | ENST00000299518 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5CDS-5UTR | ENST00000558554 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5CDS-5UTR | ENST00000558554 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5CDS-5UTR | ENST00000559205 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5CDS-5UTR | ENST00000559205 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5UTR-5UTR | ENST00000441490 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
5UTR-5UTR | ENST00000441490 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
intron-5UTR | ENST00000558535 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
intron-5UTR | ENST00000558535 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
intron-5UTR | ENST00000561366 | ENST00000409568 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
intron-5UTR | ENST00000561366 | ENST00000328828 | IDH3A | chr15 | 78441772 | + | SH2D7 | chr15 | 78386458 | + |
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FusionProtFeatures for IDH3A_SH2D7 |
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Hgene | Tgene |
IDH3A | SH2D7 |
Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IDH3A_SH2D7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IDH3A_SH2D7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IDH3A | DMWD, DDA1, PSMD4, TERF1, TERF2, MYC, S100A16, UQCRFS1P1, SUCLA2, ADRB2, MBNL1, RAB4A, STAU1, HUWE1, CUL7, EGFR, IDH3B, RDH13, IDH3G, ABCC1, ABCC3, ACO2, ACTN4, ATP2B1, CCT8, HDHD1, IDH1, ACADM, CAD, CANX, CCT6A, CCT6B, CLTCL1, CS, EPRS, ETFA, IDH2, MDH2, PPP2R1A, PSMC5, RPLP0, RPN1, SLC25A3, SUCLG2, IPO9, PSMD2, UBE2N, UQCRC2, NFATC2, DLD, SDHA, SOD1 | SH2D7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IDH3A_SH2D7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | IDH3A | P50213 | DB09092 | Xanthinol | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | small molecule | approved|withdrawn |
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RelatedDiseases for IDH3A_SH2D7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IDH3A | C0029408 | Degenerative polyarthritis | 1 | CTD_human |