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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17025

FusionGeneSummary for IDH3A_IDH3A

check button Fusion gene summary
Fusion gene informationFusion gene name: IDH3A_IDH3A
Fusion gene ID: 17025
HgeneTgene
Gene symbol

IDH3A

IDH3A

Gene ID

3419

3419

Gene nameisocitrate dehydrogenase 3 (NAD(+)) alphaisocitrate dehydrogenase 3 (NAD(+)) alpha
Synonyms--
Cytomap

15q25.1

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionisocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NAisocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NA
Modification date2018052220180522
UniProtAcc

P50213

P50213

Ensembl transtripts involved in fusion geneENST00000299518, ENST00000558554, 
ENST00000559205, ENST00000441490, 
ENST00000558535, ENST00000561366, 
ENST00000299518, ENST00000558554, 
ENST00000559205, ENST00000441490, 
ENST00000558535, ENST00000561366, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 3 X 2=12
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IDH3A [Title/Abstract] AND IDH3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI571707IDH3Achr15

78461816

-IDH3Achr15

78461510

+
ChiTaRS3.1BE887604IDH3Achr15

78461654

-IDH3Achr15

78461692

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000299518ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000299518ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000299518ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000299518ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000299518ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000299518ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558554ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558554ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558554ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000558554ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558554ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000558554ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000559205ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000559205ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000559205ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000559205ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000559205ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000559205ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000441490ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000441490ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000441490ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000441490ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000441490ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000441490ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558535ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558535ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558535ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000558535ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000558535ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-intronENST00000558535ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000561366ENST00000299518IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000561366ENST00000558554IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000561366ENST00000559205IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000561366ENST00000441490IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-3UTRENST00000561366ENST00000558535IDH3Achr15

78461816

-IDH3Achr15

78461510

+
intron-intronENST00000561366ENST00000561366IDH3Achr15

78461816

-IDH3Achr15

78461510

+
3UTR-3UTRENST00000299518ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000299518ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000299518ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000299518ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000299518ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000299518ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558554ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558554ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558554ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558554ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558554ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558554ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000559205ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000559205ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000559205ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000559205ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000559205ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000559205ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000441490ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000441490ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000441490ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000441490ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000441490ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000441490ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558535ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558535ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558535ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558535ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-3UTRENST00000558535ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
3UTR-intronENST00000558535ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000561366ENST00000299518IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000561366ENST00000558554IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000561366ENST00000559205IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000561366ENST00000441490IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-3UTRENST00000561366ENST00000558535IDH3Achr15

78461654

-IDH3Achr15

78461692

+
intron-intronENST00000561366ENST00000561366IDH3Achr15

78461654

-IDH3Achr15

78461692

+

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FusionProtFeatures for IDH3A_IDH3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDH3A

P50213

IDH3A

P50213

Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}. Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IDH3A_IDH3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IDH3A_IDH3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IDH3A_IDH3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIDH3AP50213DB09092XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialsmall moleculeapproved|withdrawn
TgeneIDH3AP50213DB09092XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialsmall moleculeapproved|withdrawn

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RelatedDiseases for IDH3A_IDH3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIDH3AC0029408Degenerative polyarthritis1CTD_human
TgeneIDH3AC0029408Degenerative polyarthritis1CTD_human