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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17024

FusionGeneSummary for IDH3A_DHX32

check button Fusion gene summary
Fusion gene informationFusion gene name: IDH3A_DHX32
Fusion gene ID: 17024
HgeneTgene
Gene symbol

IDH3A

DHX32

Gene ID

3419

55760

Gene nameisocitrate dehydrogenase 3 (NAD(+)) alphaDEAH-box helicase 32 (putative)
Synonyms-DDX32|DHLP1
Cytomap

15q25.1

10q26.2

Type of geneprotein-codingprotein-coding
Descriptionisocitrate dehydrogenase [NAD] subunit alpha, mitochondrialH-IDH alphaNAD(+)-specific ICDH subunit alphaNAD(H)-specific isocitrate dehydrogenase alpha subunitNAD+-specific ICDHisocitrate dehydrogenase (NAD+) alpha chainisocitrate dehydrogenase 3 (NAputative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32DEAD/H box 32DEAD/H helicase-like protein-1DEAH (Asp-Glu-Ala-His) box polypeptide 32DEAH box protein 32huDDX32
Modification date2018052220180523
UniProtAcc

P50213

Q7L7V1

Ensembl transtripts involved in fusion geneENST00000299518, ENST00000558554, 
ENST00000559205, ENST00000441490, 
ENST00000558535, ENST00000561366, 
ENST00000368721, ENST00000284690, 
ENST00000284688, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: IDH3A [Title/Abstract] AND DHX32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A8BT-01AIDH3Achr15

78452548

+DHX32chr10

127526956

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000299518ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
Frame-shiftENST00000299518ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
Frame-shiftENST00000299518ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-
Frame-shiftENST00000558554ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
Frame-shiftENST00000558554ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
Frame-shiftENST00000558554ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000559205ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000559205ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000559205ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000441490ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000441490ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000441490ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-
3UTR-3CDSENST00000558535ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
3UTR-3CDSENST00000558535ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
3UTR-3CDSENST00000558535ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000561366ENST00000368721IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000561366ENST00000284690IDH3Achr15

78452548

+DHX32chr10

127526956

-
intron-3CDSENST00000561366ENST00000284688IDH3Achr15

78452548

+DHX32chr10

127526956

-

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FusionProtFeatures for IDH3A_DHX32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDH3A

P50213

DHX32

Q7L7V1

Catalytic subunit of the enzyme which catalyzes thedecarboxylation of isocitrate (ICT) into alpha-ketoglutarate. Theheterodimer composed of the alpha (IDH3A) and beta (IDH3B)subunits and the heterodimer composed of the alpha (IDH3A) andgamma (IDH3G) subunits, have considerable basal activity but thefull activity of the heterotetramer (containing two subunits ofIDH3A, one of IDH3B and one of IDH3G) requires the assembly andcooperative function of both heterodimers.{ECO:0000269|PubMed:28139779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IDH3A_DHX32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IDH3A_DHX32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IDH3ADMWD, DDA1, PSMD4, TERF1, TERF2, MYC, S100A16, UQCRFS1P1, SUCLA2, ADRB2, MBNL1, RAB4A, STAU1, HUWE1, CUL7, EGFR, IDH3B, RDH13, IDH3G, ABCC1, ABCC3, ACO2, ACTN4, ATP2B1, CCT8, HDHD1, IDH1, ACADM, CAD, CANX, CCT6A, CCT6B, CLTCL1, CS, EPRS, ETFA, IDH2, MDH2, PPP2R1A, PSMC5, RPLP0, RPN1, SLC25A3, SUCLG2, IPO9, PSMD2, UBE2N, UQCRC2, NFATC2, DLD, SDHA, SOD1DHX32FAM161A, LIPH, MCM2, ZNF785, NUDCD1, MRPL16, ZBBX, POLRMT


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IDH3A_DHX32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIDH3AP50213DB09092XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialsmall moleculeapproved|withdrawn

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RelatedDiseases for IDH3A_DHX32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIDH3AC0029408Degenerative polyarthritis1CTD_human