	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 16993

FusionGeneSummary for IARS_SLC10A7

Fusion gene summary

Fusion gene information	Fusion gene name: IARS_SLC10A7
	Fusion gene ID: 16993
		Hgene	Tgene
	Gene symbol	IARS	SLC10A7
	Gene ID	3376	84068
	Gene name	isoleucyl-tRNA synthetase	solute carrier family 10 member 7
	Synonyms	GRIDHH\|IARS1\|ILERS\|ILRS\|IRS\|PRO0785	C4orf13\|P7
	Cytomap	9q22.31	4q31.22
	Type of gene	protein-coding	protein-coding
	Description	isoleucine--tRNA ligase, cytoplasmicisoleucine tRNA ligase 1, cytoplasmic	sodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7
	Modification date	20180523	20180519
	UniProtAcc	P41252	Q0GE19
	Ensembl transtripts involved in fusion gene	ENST00000375643, ENST00000375629, ENST00000443024, ENST00000447699, ENST00000375627, ENST00000474340,	ENST00000432059, ENST00000335472, ENST00000264986, ENST00000507030, ENST00000394062, ENST00000394059, ENST00000511315, ENST00000511374, ENST00000502607,
Fusion gene scores	* DoF score	7 X 9 X 2=126	2 X 2 X 2=8
	# samples	11	2
	** MAII score	log2(11/126*10)=-0.195920209975257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: IARS [Title/Abstract] AND SLC10A7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IARS	GO:0006428	isoleucyl-tRNA aminoacylation	8052601

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			W52666	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000375643	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+

Top

FusionProtFeatures for IARS_SLC10A7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IARS P41252	SLC10A7 Q0GE19
Catalyzes the specific attachment of an amino acid toits cognate tRNA in a 2 step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. {ECO:0000269\|PubMed:8052601}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for IARS_SLC10A7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IARS_SLC10A7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for IARS_SLC10A7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for IARS_SLC10A7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SLC10A7	C0008370	Cholestasis	1	CTD_human
Tgene	SLC10A7	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 16993

FusionGeneSummary for IARS_SLC10A7

FusionProtFeatures for IARS_SLC10A7

FusionGeneSequence for IARS_SLC10A7

FusionGenePPI for IARS_SLC10A7

RelatedDrugs for IARS_SLC10A7

RelatedDiseases for IARS_SLC10A7