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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16986

FusionGeneSummary for HYPK_HSPA4L

check button Fusion gene summary
Fusion gene informationFusion gene name: HYPK_HSPA4L
Fusion gene ID: 16986
HgeneTgene
Gene symbol

HYPK

HSPA4L

Gene ID

25764

22824

Gene namehuntingtin interacting protein Kheat shock protein family A (Hsp70) member 4 like
SynonymsC15orf63|HSPC136APG-1|HSPH3|Osp94
Cytomap

15q15.3

4q28.1

Type of geneprotein-codingprotein-coding
Descriptionhuntingtin-interacting protein Khuntingtin yeast partner Kheat shock 70 kDa protein 4Lheat shock 70 kDa protein 4-like proteinheat shock 70-related protein APG-1heat shock 70kDa protein 4-likeheat shock protein (hsp110 family)osmotic stress protein 94testis tissue sperm-binding protein Li 64n
Modification date2018051920180523
UniProtAcc

Q9NX55

O95757

Ensembl transtripts involved in fusion geneENST00000406925, ENST00000498605, 
ENST00000442995, ENST00000458412, 
ENST00000439123, ENST00000508776, 
ENST00000296464, ENST00000505726, 
ENST00000515262, 
Fusion gene scores* DoF score3 X 3 X 1=91 X 1 X 1=1
# samples 31
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: HYPK [Title/Abstract] AND HSPA4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHYPK

GO:0043066

negative regulation of apoptotic process

17947297

HgeneHYPK

GO:0050821

protein stabilization

17947297


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF700151HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000406925ENST00000439123HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000406925ENST00000508776HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000406925ENST00000296464HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000406925ENST00000505726HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-3UTRENST00000406925ENST00000515262HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
intron-intronENST00000498605ENST00000439123HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
intron-intronENST00000498605ENST00000508776HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
intron-intronENST00000498605ENST00000296464HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
intron-intronENST00000498605ENST00000505726HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
intron-3UTRENST00000498605ENST00000515262HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000442995ENST00000439123HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000442995ENST00000508776HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000442995ENST00000296464HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000442995ENST00000505726HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-3UTRENST00000442995ENST00000515262HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000458412ENST00000439123HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000458412ENST00000508776HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000458412ENST00000296464HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-intronENST00000458412ENST00000505726HYPKchr15

44094039

+HSPA4Lchr4

128734354

-
3UTR-3UTRENST00000458412ENST00000515262HYPKchr15

44094039

+HSPA4Lchr4

128734354

-

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FusionProtFeatures for HYPK_HSPA4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HYPK

Q9NX55

HSPA4L

O95757

Has a chaperone-like activity preventing polyglutamine(polyQ) aggregation of HTT. Protects against HTT polyQ-mediatedapoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.{ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145}. Possesses chaperone activity in vitro where it inhibitsaggregation of citrate synthase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HYPK_HSPA4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HYPK_HSPA4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HYPK_HSPA4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HYPK_HSPA4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource