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Fusion gene ID: 16986 |
FusionGeneSummary for HYPK_HSPA4L |
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Fusion gene information | Fusion gene name: HYPK_HSPA4L | Fusion gene ID: 16986 | Hgene | Tgene | Gene symbol | HYPK | HSPA4L | Gene ID | 25764 | 22824 |
Gene name | huntingtin interacting protein K | heat shock protein family A (Hsp70) member 4 like | |
Synonyms | C15orf63|HSPC136 | APG-1|HSPH3|Osp94 | |
Cytomap | 15q15.3 | 4q28.1 | |
Type of gene | protein-coding | protein-coding | |
Description | huntingtin-interacting protein Khuntingtin yeast partner K | heat shock 70 kDa protein 4Lheat shock 70 kDa protein 4-like proteinheat shock 70-related protein APG-1heat shock 70kDa protein 4-likeheat shock protein (hsp110 family)osmotic stress protein 94testis tissue sperm-binding protein Li 64n | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NX55 | O95757 | |
Ensembl transtripts involved in fusion gene | ENST00000406925, ENST00000498605, ENST00000442995, ENST00000458412, | ENST00000439123, ENST00000508776, ENST00000296464, ENST00000505726, ENST00000515262, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: HYPK [Title/Abstract] AND HSPA4L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HYPK | GO:0043066 | negative regulation of apoptotic process | 17947297 |
Hgene | HYPK | GO:0050821 | protein stabilization | 17947297 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF700151 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000406925 | ENST00000439123 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000406925 | ENST00000508776 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000406925 | ENST00000296464 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000406925 | ENST00000505726 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-3UTR | ENST00000406925 | ENST00000515262 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
intron-intron | ENST00000498605 | ENST00000439123 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
intron-intron | ENST00000498605 | ENST00000508776 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
intron-intron | ENST00000498605 | ENST00000296464 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
intron-intron | ENST00000498605 | ENST00000505726 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
intron-3UTR | ENST00000498605 | ENST00000515262 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000442995 | ENST00000439123 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000442995 | ENST00000508776 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000442995 | ENST00000296464 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000442995 | ENST00000505726 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-3UTR | ENST00000442995 | ENST00000515262 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000458412 | ENST00000439123 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000458412 | ENST00000508776 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000458412 | ENST00000296464 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-intron | ENST00000458412 | ENST00000505726 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
3UTR-3UTR | ENST00000458412 | ENST00000515262 | HYPK | chr15 | 44094039 | + | HSPA4L | chr4 | 128734354 | - |
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FusionProtFeatures for HYPK_HSPA4L |
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Hgene | Tgene |
HYPK | HSPA4L |
Has a chaperone-like activity preventing polyglutamine(polyQ) aggregation of HTT. Protects against HTT polyQ-mediatedapoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.{ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145}. | Possesses chaperone activity in vitro where it inhibitsaggregation of citrate synthase. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HYPK_HSPA4L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HYPK_HSPA4L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HYPK_HSPA4L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HYPK_HSPA4L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |