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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16971

FusionGeneSummary for HYAL2_HYAL2

check button Fusion gene summary
Fusion gene informationFusion gene name: HYAL2_HYAL2
Fusion gene ID: 16971
HgeneTgene
Gene symbol

HYAL2

HYAL2

Gene ID

8692

8692

Gene namehyaluronoglucosaminidase 2hyaluronoglucosaminidase 2
SynonymsLUCA2LUCA2
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionhyaluronidase-2PH-20 homologPH20 homologhyal-2lung carcinoma protein 2lysosomal hyaluronidasehyaluronidase-2PH-20 homologPH20 homologhyal-2lung carcinoma protein 2lysosomal hyaluronidase
Modification date2018052020180520
UniProtAcc

Q12891

Q12891

Ensembl transtripts involved in fusion geneENST00000447092, ENST00000357750, 
ENST00000395139, ENST00000442581, 
ENST00000447092, ENST00000357750, 
ENST00000395139, ENST00000442581, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: HYAL2 [Title/Abstract] AND HYAL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHYAL2

GO:0000302

response to reactive oxygen species

20554532

HgeneHYAL2

GO:0006027

glycosaminoglycan catabolic process

9712871

HgeneHYAL2

GO:0009615

response to virus

11296287|12676986

HgeneHYAL2

GO:0010764

negative regulation of fibroblast migration

19577615

HgeneHYAL2

GO:0019064

fusion of virus membrane with host plasma membrane

11296287

HgeneHYAL2

GO:0019087

transformation of host cell by virus

11296287

HgeneHYAL2

GO:0030214

hyaluronan catabolic process

17170110|19443707|20554532|21699545

HgeneHYAL2

GO:0030308

negative regulation of cell growth

18725949

HgeneHYAL2

GO:0042117

monocyte activation

19443707

HgeneHYAL2

GO:0043407

negative regulation of MAP kinase activity

12676986

HgeneHYAL2

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

HgeneHYAL2

GO:0050729

positive regulation of inflammatory response

19443707

HgeneHYAL2

GO:0051898

negative regulation of protein kinase B signaling

12676986

HgeneHYAL2

GO:0061099

negative regulation of protein tyrosine kinase activity

12676986

HgeneHYAL2

GO:0071347

cellular response to interleukin-1

18390475

HgeneHYAL2

GO:0071493

cellular response to UV-B

21699545

HgeneHYAL2

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691

HgeneHYAL2

GO:2000484

positive regulation of interleukin-8 secretion

19443707

HgeneHYAL2

GO:2000778

positive regulation of interleukin-6 secretion

19443707

TgeneHYAL2

GO:0000302

response to reactive oxygen species

20554532

TgeneHYAL2

GO:0006027

glycosaminoglycan catabolic process

9712871

TgeneHYAL2

GO:0009615

response to virus

11296287|12676986

TgeneHYAL2

GO:0010764

negative regulation of fibroblast migration

19577615

TgeneHYAL2

GO:0019064

fusion of virus membrane with host plasma membrane

11296287

TgeneHYAL2

GO:0019087

transformation of host cell by virus

11296287

TgeneHYAL2

GO:0030214

hyaluronan catabolic process

17170110|19443707|20554532|21699545

TgeneHYAL2

GO:0030308

negative regulation of cell growth

18725949

TgeneHYAL2

GO:0042117

monocyte activation

19443707

TgeneHYAL2

GO:0043407

negative regulation of MAP kinase activity

12676986

TgeneHYAL2

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

TgeneHYAL2

GO:0050729

positive regulation of inflammatory response

19443707

TgeneHYAL2

GO:0051898

negative regulation of protein kinase B signaling

12676986

TgeneHYAL2

GO:0061099

negative regulation of protein tyrosine kinase activity

12676986

TgeneHYAL2

GO:0071347

cellular response to interleukin-1

18390475

TgeneHYAL2

GO:0071493

cellular response to UV-B

21699545

TgeneHYAL2

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691

TgeneHYAL2

GO:2000484

positive regulation of interleukin-8 secretion

19443707

TgeneHYAL2

GO:2000778

positive regulation of interleukin-6 secretion

19443707


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CF131370HYAL2chr3

50357153

-HYAL2chr3

50358599

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000447092ENST00000447092HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000447092ENST00000357750HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000447092ENST00000395139HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000447092ENST00000442581HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-5UTRENST00000357750ENST00000447092HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000357750ENST00000357750HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000357750ENST00000395139HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000357750ENST00000442581HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-5UTRENST00000395139ENST00000447092HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000395139ENST00000357750HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000395139ENST00000395139HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000395139ENST00000442581HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-5UTRENST00000442581ENST00000447092HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000442581ENST00000357750HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000442581ENST00000395139HYAL2chr3

50357153

-HYAL2chr3

50358599

-
intron-intronENST00000442581ENST00000442581HYAL2chr3

50357153

-HYAL2chr3

50358599

-

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FusionProtFeatures for HYAL2_HYAL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HYAL2

Q12891

HYAL2

Q12891

Hydrolyzes high molecular weight hyaluronic acid toproduce an intermediate-sized product which is further hydrolyzedby sperm hyaluronidase to give small oligosaccharides. Displaysvery low levels of activity. Associates with and negativelyregulates MST1R. {ECO:0000269|PubMed:11296287,ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}. Hydrolyzes high molecular weight hyaluronic acid toproduce an intermediate-sized product which is further hydrolyzedby sperm hyaluronidase to give small oligosaccharides. Displaysvery low levels of activity. Associates with and negativelyregulates MST1R. {ECO:0000269|PubMed:11296287,ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HYAL2_HYAL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HYAL2_HYAL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HYAL2_HYAL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HYAL2_HYAL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource