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Fusion gene ID: 16952 |
FusionGeneSummary for HTT_TMED4 |
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Fusion gene information | Fusion gene name: HTT_TMED4 | Fusion gene ID: 16952 | Hgene | Tgene | Gene symbol | HTT | TMED4 | Gene ID | 6532 | 222068 |
Gene name | solute carrier family 6 member 4 | transmembrane p24 trafficking protein 4 | |
Synonyms | 5-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|SERT1|hSERT | ERS25|GMP25iso|HNLF|p24a3|p24alpha3 | |
Cytomap | 17q11.2 | 7p13 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium-dependent serotonin transporter5-hydroxytryptamine (serotonin) transporter5HT transporterNa+/Cl- dependent serotonin transporterserotonin transporter 1solute carrier family 6 (neurotransmitter transporter), member 4solute carrier family 6 (ne | transmembrane emp24 domain-containing protein 4endoplasmic reticulum stress-response protein 25 kDap24 family protein alpha-3putative NF-kappa-B-activating protein 156putative NFkB activating protein HNLFtransmembrane emp24 protein transport domain c | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P42858 | Q7Z7H5 | |
Ensembl transtripts involved in fusion gene | ENST00000355072, ENST00000513806, | ENST00000457408, ENST00000289577, ENST00000481238, ENST00000444131, | |
Fusion gene scores | * DoF score | 8 X 12 X 8=768 | 2 X 2 X 1=4 |
# samples | 12 | 2 | |
** MAII score | log2(12/768*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: HTT [Title/Abstract] AND TMED4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HTT | GO:0006837 | serotonin transport | 19270731 |
Hgene | HTT | GO:0009636 | response to toxic substance | 17575980 |
Hgene | HTT | GO:0015844 | monoamine transport | 16024787 |
Hgene | HTT | GO:0051610 | serotonin uptake | 8987735|16870614|17506858|18227069|19270731 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE766597 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000355072 | ENST00000457408 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-intron | ENST00000355072 | ENST00000289577 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-intron | ENST00000355072 | ENST00000481238 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-5UTR | ENST00000355072 | ENST00000444131 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-3CDS | ENST00000513806 | ENST00000457408 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-intron | ENST00000513806 | ENST00000289577 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-intron | ENST00000513806 | ENST00000481238 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
intron-5UTR | ENST00000513806 | ENST00000444131 | HTT | chr4 | 3231263 | - | TMED4 | chr7 | 44620802 | + |
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FusionProtFeatures for HTT_TMED4 |
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Hgene | Tgene |
HTT | TMED4 |
May play a role in microtubule-mediated transport orvesicle function. | Involved in vesicular protein trafficking, mainly in theearly secretory pathway. targeting. Involved in the maintenance ofthe Golgi apparatus. Appears to play a role in the biosynthesis ofsecreted cargo including processing. Involved in endoplasmicreticulum stress response. May play a role in the regulation ofheat-shock response and apoptosis (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HTT_TMED4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HTT_TMED4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HTT_TMED4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HTT_TMED4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HTT | C0020179 | Huntington Disease | 9 | CTD_human;ORPHANET |
Hgene | HTT | C0011570 | Mental Depression | 4 | PSYGENET |
Hgene | HTT | C0011581 | Depressive disorder | 4 | HPO;PSYGENET |
Hgene | HTT | C0525045 | Mood Disorders | 2 | PSYGENET |
Hgene | HTT | C0006635 | Cadmium poisoning | 1 | CTD_human |
Hgene | HTT | C0026650 | Movement Disorders | 1 | CTD_human;HPO |
Hgene | HTT | C0677050 | Manganese Poisoning | 1 | CTD_human |